Molecular insights into insulin action and secretion (Q34655565)

3 August 2017

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title

Molecular insights into insulin action and secretion (English)

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3 August 2017

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Rhodes CJ

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3 August 2017

White MF

series ordinal

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3 August 2017

publication date

1 June 2002

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European Journal of Clinical Investigation

3 August 2017

published in

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3 August 2017

volume

32 Suppl 3

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3 August 2017

page(s)

3-13

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The IRS-signalling system during insulin and cytokine action

3 August 2017

cites work

1 reference

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Characterization of the growth of murine fibroblasts that express human insulin receptors. I. The effect of insulin in the absence of other growth factors

21 January 2018

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Pathogenetic mechanisms of impaired glucose tolerance and type II diabetes in African-Americans. The significance of insulin secretion, insulin sensitivity, and glucose effectiveness

21 January 2018

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Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study

21 January 2018

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The insulin signalling system and the IRS proteins

21 January 2018

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Insulin signal transduction through protein kinase cascades

21 January 2018

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IGF-I: a mitogen also involved in differentiation processes in mammalian cells

21 January 2018

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Human diabetes associated with a mutation in the tyrosine kinase domain of the insulin receptor

21 January 2018

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Homozygous deletion of the human insulin receptor gene results in leprechaunism

21 January 2018

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Homozygous nonsense mutation in the insulin receptor gene in infant with leprechaunism.

21 January 2018

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Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes.

21 January 2018

1 reference

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Insulin-stimulated insulin secretion in single pancreatic beta cells.

21 January 2018

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Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity

21 January 2018

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A model to explore the interaction between muscle insulin resistance and beta-cell dysfunction in the development of type 2 diabetes

21 January 2018

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Role of brain insulin receptor in control of body weight and reproduction

21 January 2018

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Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

21 January 2018

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Role of IRS-2 in insulin and cytokine signalling

21 January 2018

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A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family

21 January 2018

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene.

21 January 2018

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Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1.

21 January 2018

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Insulin signalling and insulin actions in the muscles and livers of insulin-resistant, insulin receptor substrate 1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.

21 January 2018

1 reference

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Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Disruption of IRS-2 causes type 2 diabetes in mice

21 January 2018

1 reference

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Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Insulin receptor substrate 3 is not essential for growth or glucose homeostasis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Discrete expression of insulin receptor substrate-4 mRNA in adult rat brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

21 January 2018

1 reference

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Peripheral but not hepatic insulin resistance in mice with one disrupted allele of the glucose transporter type 4 (GLUT4) gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

21 January 2018

1 reference

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Stimulus-secretion coupling in pancreatic beta cells.

21 January 2018

1 reference

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Aspects of novel sites of regulation of the insulin stimulus-secretion coupling in normal and diabetic pancreatic islets

21 January 2018

1 reference

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Localized calcium influx in pancreatic beta-cells: its significance for Ca2+-dependent insulin secretion from the islets of Langerhans

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Signal transduction mechanisms in nutrient-induced insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Metabolic control of beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

The role of cytosolic free Ca2+ and protein kinase C in acetylcholine-induced insulin release in the clonal beta-cell line, HIT-T15.

21 January 2018

1 reference

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The role of protein kinase C in cholinergic stimulation of insulin secretion from rat islets of Langerhans

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Glucose regulation of gene transcription

21 January 2018

1 reference

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Insulin secretory granule biogenesis. Co-ordinate regulation of the biosynthesis of the majority of constituent proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Biosynthesis of insulin secretory granule membrane proteins. Control by glucose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Cooperativity between the preproinsulin mRNA untranslated regions is necessary for glucose-stimulated translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Glucose-regulated translational control of proinsulin biosynthesis with that of the proinsulin endopeptidases PC2 and PC3 in the insulin-producing MIN6 cell line

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Specific co-ordinated regulation of PC3 and PC2 gene expression with that of preproinsulin in insulin-producing beta TC3 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Translational control of insulin biosynthesis. Evidence for regulation of elongation, initiation and signal-recognition-particle-mediated translational arrest by glucose.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Evolution of abnormal insulin secretory responses during 48-h in vivo hyperglycemia

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Increased secretory demand rather than a defect in the proinsulin conversion mechanism causes hyperproinsulinemia in a glucose-infusion rat model of non-insulin-dependent diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

The evolution of beta-cell dysfunction and insulin resistance in type 2 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

beta-cell turnover: its assessment and implications

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Pancreatic beta-cell growth and diabetes mellitus

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Hypoinsulinaemia, glucose intolerance and diminished beta-cell size in S6K1-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Insulin-like growth factor I (IGF-I)-stimulated pancreatic beta-cell growth is glucose-dependent. Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Stimulation of pancreatic beta-cell proliferation by growth hormone is glucose-dependent: signal transduction via janus kinase 2 (JAK2)/signal transducer and activator of transcription 5 (STAT5) with no crosstalk to insulin receptor substrate-mediat

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Activation of mitogen-activating protein kinase by glucose is not required for insulin secretion

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Free fatty acid-induced inhibition of glucose and insulin-like growth factor I-induced deoxyribonucleic acid synthesis in the pancreatic beta-cell line INS-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

IGF-I and GH post-receptor signaling mechanisms for pancreatic beta-cell replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Differential activation of protein kinase B and p70(S6)K by glucose and insulin-like growth factor 1 in pancreatic beta-cells (INS-1).

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Cellular mechanisms of insulin resistance

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

A new antidiabetic agent, BRL 49653, reduces lipid availability and improves insulin action and glucoregulation in the rat.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

The insulin sensitizer, BRL 49653, reduces systemic fatty acid supply and utilization and tissue lipid availability in the rat

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Glucose and tolbutamide induce apoptosis in pancreatic beta-cells. A process dependent on intracellular Ca2+ concentration

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Beta-cell deterioration--prospects for reversal or prevention

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Beta-cell mass dynamics in Zucker diabetic fatty rats. Rosiglitazone prevents the rise in net cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines

21 January 2018

1 reference

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IRS proteins and beta-cell function

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

IRS-2 pathways integrate female reproduction and energy homeostasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

Translational control of proinsulin synthesis by glucose

21 January 2018

1 reference

https://api.crossref.org/works/10.1046%2FJ.1365-2362.32.S3.2.X

10.1046/J.1365-2362.32.S3.2.X

21 January 2018

Identifiers

DOI

1 reference

3 August 2017

1 reference