Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal (Q36052545)

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English	Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal	scientific article

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scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

N-retinylidene-N-retinylethanolamine

1 reference

ChEBI release 2020-05-28

author name string

Nicholas P Boyer

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Daniel Higbee

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Mark B Currin

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Lorie R Blakeley

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Chunhe Chen

5

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Zsolt Ablonczy

6

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Rosalie K Crouch

7

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Yiannis Koutalos

8

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Europe PubMed Central

PMC publication ID

11 August 2017

language of work or name

0 references

publication date

8 May 2012

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Journal of Biological Chemistry

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Europe PubMed Central

PMC publication ID

11 August 2017

287

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

26

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

22276-22286

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Lipofuscin and A2E accumulate with age in the retinal pigment epithelium of Nrl-/- mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Mechanism of all-trans-retinal toxicity with implications for stargardt disease and age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Rod Outer Segment Retinol Formation Is Independent of Abca4, Arrestin, Rhodopsin Kinase, and Rhodopsin Palmitylation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Spatial Localization of A2E in the Retinal Pigment Epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Mass spectrometry provides accurate and sensitive quantitation of A2E

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Rapid formation of all-trans retinol after bleaching in frog and mouse rod photoreceptor outer segments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Structural characterization of bisretinoid A2E photocleavage products and implications for age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence intensity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Phospholipid meets all-trans-retinal: the making of RPE bisretinoids

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Limited roles of Rdh8, Rdh12, and Abca4 in all-trans-retinal clearance in mouse retina

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Formation of all-trans retinol after visual pigment bleaching in mouse photoreceptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

The role of the photoreceptor ABC transporter ABCA4 in lipid transport and Stargardt macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Retinal pigment epithelium lipofuscin proteomics.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

RPE lipofuscin and its role in retinal pathobiology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

The human ATP-binding cassette (ABC) transporter superfamily

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Delayed dark-adaptation and lipofuscin accumulation in abcr+/- mice: implications for involvement of ABCR in age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Vertebrate photoreceptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Oxidative damage and age-related macular degeneration

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Insights into the function of Rim protein in photoreceptors and etiology of Stargardt's disease from the phenotype in abcr knockout mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Retinal stimulates ATP hydrolysis by purified and reconstituted ABCR, the photoreceptor-specific ATP-binding cassette transporter responsible for Stargardt disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Characterization of phospholipase D activity in bovine photoreceptor membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar media

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

A photoreceptor cell-specific ATP-binding transporter gene (ABCR) is mutated in recessive Stargardt macular dystrophy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Photolyzed rhodopsin catalyzes the exchange of GTP for bound GDP in retinal rod outer segments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

The renewal of photoreceptor cell outer segments

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Participation of the retinal pigment epithelium in the rod outer segment renewal process

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Influence of early photoreceptor degeneration on lipofuscin in the retinal pigment epithelium

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

Retinal light damage reduces autofluorescent pigment deposition in the retinal pigment epithelium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

2 October 2017

What is lipofuscin? Defining characteristics and differentiation from other autofluorescent lysosomal storage bodies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

11 July 2018

Mole quantity of RPE65 and its productivity in the generation of 11-cis-retinal from retinyl esters in the living mouse eye.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

23 September 2018

N-retinylidene-phosphatidylethanolamine is the preferred retinoid substrate for the photoreceptor-specific ABC transporter ABCA4 (ABCR).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

23 September 2018

Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

23 September 2018

Effect of Rpe65 knockout on accumulation of lipofuscin fluorophores in the retinal pigment epithelium.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

23 September 2018

The Rpe65 Leu450Met variation increases retinal resistance against light-induced degeneration by slowing rhodopsin regeneration.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

23 September 2018

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3381188

23 September 2018

Allelic variation in ABCR associated with Stargardt disease but not age-related macular degeneration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.329235

21 January 2018

Retinal age pigments generated by self-assembling lysosomotropic detergents

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M111.329235

21 January 2018

Rod outer segment retinol dehydrogenase: substrate specificity and role in phototransduction

1 reference

https://pubmed.ncbi.nlm.nih.gov/22570475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane

1 reference

https://pubmed.ncbi.nlm.nih.gov/22570475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo measurement of lipofuscin in Stargardt's disease--Fundus flavimaculatus

1 reference

https://pubmed.ncbi.nlm.nih.gov/22570475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Formation of lipofuscin-like fluorophores by reaction of retinal with photoreceptor outer segments and liposomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/22570475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of native retinal fluorophores involved in biosynthesis of A2E and lipofuscin-associated retinopathies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22570475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics

1 reference

https://pubmed.ncbi.nlm.nih.gov/22570475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Age-related accumulation and spatial distribution of lipofuscin in RPE of normal subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/22570475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The topography and age relationship of lipofuscin concentration in the retinal pigment epithelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/22570475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Circadian nature of rod outer segment disc shedding in the rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/22570475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/22570475

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1074/JBC.M111.329235

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

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