Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence intensity. (Q33732517)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19800359%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

title

Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence intensity (English)

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9 February 2020

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9 February 2020

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9 February 2020

Janet R Sparrow

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9 February 2020

publication date

1 October 2009

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9 February 2020

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9 February 2020

volume

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9 February 2020

issue

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9 February 2020

page(s)

729-736

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Novel lipofuscin bisretinoids prominent in human retina and in a model of recessive Stargardt disease

9 February 2020

cites work

1 reference

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Complement activation by bisretinoid constituents of RPE lipofuscin

21 June 2018

1 reference

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Mechanisms involved in A2E oxidation

21 June 2018

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The all-trans-retinal dimer series of lipofuscin pigments in retinal pigment epithelial cells in a recessive Stargardt disease model.

21 June 2018

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Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway

21 June 2018

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Complement activation by photooxidation products of A2E, a lipofuscin constituent of the retinal pigment epithelium

21 June 2018

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Reductions in Serum Vitamin A Arrest Accumulation of Toxic Retinal Fluorophores: A Potential Therapy for Treatment of Lipofuscin-Based Retinal Diseases

21 June 2018

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Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate

21 June 2018

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Fundus autofluorescence and fundus perimetry in the junctional zone of geographic atrophy in patients with age-related macular degeneration

21 June 2018

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Rpe65 Leu450Met variant is associated with reduced levels of the retinal pigment epithelium lipofuscin fluorophores A2E and iso-A2E.

21 June 2018

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A2E-epoxides damage DNA in retinal pigment epithelial cells. Vitamin E and other antioxidants inhibit A2E-epoxide formation

21 June 2018

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Fundus autofluorescence in patients with age-related macular degeneration and high risk of visual loss

21 June 2018

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Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration.

21 June 2018

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A2E, a lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture.

21 June 2018

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Patterns of increased in vivo fundus autofluorescence in the junctional zone of geographic atrophy of the retinal pigment epithelium associated with age-related macular degeneration

21 June 2018

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Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epithelium

21 June 2018

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In vivo fundus autofluorescence in macular dystrophies

21 June 2018

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Fluorophores of the human retinal pigment epithelium: Separation and spectral characterization

21 June 2018

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Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin

21 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840058

Mechanisms for the induction of HNE- MDA- and AGE-adducts, RAGE and VEGF in retinal pigment epithelial cells

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840058

Absolute configurational determination of an all-trans-retinal dimer isolated from photoreceptor outer segments

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840058

Photopic and scotopic fine matrix mapping of retinal areas of increased fundus autofluorescence in patients with age-related maculopathy

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840058

DNA Is a Target of the Photodynamic Effects Elicited in A2E-Laden RPE by Blue-Light Illumination

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840058

Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvement

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840058

Involvement of oxidative mechanisms in blue-light-induced damage to A2E-laden RPE.

30 October 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840058

Biosynthetic studies of A2E, a major fluorophore of retinal pigment epithelial lipofuscin

30 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2840058

The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigmented epithelial cells.

30 October 2018

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Retinal age pigments generated by self-assembling lysosomotropic detergents

30 October 2018

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The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membrane

7 January 2021

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Phenotypic Subtypes of Stargardt Macular Dystrophy–Fundus Flavimaculatus

7 January 2021

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Ocular Age Pigment “A2-E”: An Unprecedented Pyridinium Bisretinoid

7 January 2021

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In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics

7 January 2021

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12 December 2020

In vivo measurement of lipofuscin in Stargardt's disease--Fundus flavimaculatus

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12 December 2020

Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope

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12 December 2020

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12 December 2020

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19800359%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19800359%20AND%20SRC:MED&resulttype=core&format=json

9 February 2020

PubMed publication ID

19800359

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19800359%20AND%20SRC:MED&resulttype=core&format=json