Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion (Q36042084)

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English	Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

11 August 2017

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

1 reference

based on heuristic

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6

object named as

Pascal Gervaz

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Europe PubMed Central

PMC publication ID

11 August 2017

author name string

Frédéric Varnat

1

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Europe PubMed Central

PMC publication ID

11 August 2017

Arnaud Duquet

2

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Europe PubMed Central

PMC publication ID

11 August 2017

Monica Malerba

3

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Europe PubMed Central

PMC publication ID

11 August 2017

Marie Zbinden

4

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Europe PubMed Central

PMC publication ID

11 August 2017

Christophe Mas

5

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Europe PubMed Central

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11 August 2017

Ariel Ruiz i Altaba

7

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Europe PubMed Central

PMC publication ID

11 August 2017

publication date

1 September 2009

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Europe PubMed Central

PMC publication ID

11 August 2017

EMBO Molecular Medicine

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Europe PubMed Central

PMC publication ID

11 August 2017

1

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Europe PubMed Central

PMC publication ID

11 August 2017

6-7

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

338-351

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Hedgehog signaling is involved in differentiation of normal colonic tissue rather than in tumor proliferation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

2 October 2017

Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis

1 reference

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A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

1 reference

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Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

1 reference

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An integrated genomic analysis of human glioblastoma multiforme

1 reference

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Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity.

1 reference

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A paracrine requirement for hedgehog signalling in cancer

1 reference

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2 October 2017

CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors

1 reference

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Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4.

1 reference

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Biological and genetic characteristics of tumor-initiating cells in colon cancer

1 reference

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The genomic landscapes of human breast and colorectal cancers

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The Gli code: an information nexus regulating cell fate, stemness and cancer.

1 reference

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Hedgehog signaling pathway is inactive in colorectal cancer cell lines

1 reference

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Sonic hedgehog-Gli1 pathway in colorectal adenocarcinomas

1 reference

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Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways.

1 reference

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HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

1 reference

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A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

1 reference

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Identification and expansion of human colon-cancer-initiating cells

1 reference

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Sonic Hedgehog-dependent proliferation in a series of patients with colorectal cancer

1 reference

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2 October 2017

Gli1, downregulated in colorectal cancers, inhibits proliferation of colon cancer cells involving Wnt signalling activation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

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Snail induction is an early response to Gli1 that determines the efficiency of epithelial transformation

1 reference

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In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

1 reference

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Sonic hedgehog-patched Gli signaling in the developing rat prostate gland: lobe-specific suppression by neonatal estrogens reduces ductal growth and branching

1 reference

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Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

1 reference

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2 October 2017

Expression of Sonic hedgehog pathway genes is altered in colonic neoplasia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

2 October 2017

Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

2 October 2017

Indian Hedgehog is an antagonist of Wnt signaling in colonic epithelial cell differentiation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

2 October 2017

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

1 reference

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The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells

1 reference

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The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

1 reference

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The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells

1 reference

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The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

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Gli proteins encode context-dependent positive and negative functions: implications for development and disease

1 reference

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2 October 2017

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

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Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

1 reference

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Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC

1 reference

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Cyclopamine and related steroidal alkaloid teratogens: their occurrence, structural relationship, and biologic effects

1 reference

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Prominin-1/CD133 marks stem cells and early progenitors in mouse small intestine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

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Therapeutic inhibition of Hedgehog-GLI signaling in cancer: epithelial, stromal, or stem cell targets?

1 reference

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Sonic hedgehog mRNA expression by real-time quantitative PCR in normal and tumor tissues from colorectal cancer patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

23 September 2018

Epithelial hedgehog signals pattern the intestinal crypt-villus axis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

23 September 2018

Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

23 September 2018

Teratogen-mediated inhibition of target tissue response to Shh signaling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3378144

23 September 2018

Teratogenic compounds ofVeratrum californicum (Durand). X. Cyclopia in rabbits produced by cyclopamine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20049737

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Smoothened gene mutations found in digestive cancer have no aberrant Hedgehog signaling activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20049737

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1002/EMMM.200900039

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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