Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. (Q35722779)

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28 December 2019

title

Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways (English)

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28 December 2019

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28 December 2019

1 reference

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28 December 2019

Vincent Piguet

1 reference

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28 December 2019

Virginie Clement

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28 December 2019

Marie Zbinden

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28 December 2019

Rafael Correa

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28 December 2019

Friedrich Beermann

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28 December 2019

Ariel Ruiz I Altaba

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28 December 2019

language of work or name

English

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publication date

28 March 2007

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Proceedings of the National Academy of Sciences of the United States of America

28 December 2019

published in

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28 December 2019

volume

104

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28 December 2019

issue

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28 December 2019

page(s)

5895-5900

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HEDGEHOG-GLI1 signaling regulates human glioma growth, cancer stem cell self-renewal, and tumorigenicity

28 December 2019

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12 July 2018

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Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling

12 July 2018

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Regulation of Gli1 localization by the cAMP/protein kinase A signaling axis through a site near the nuclear localization signal

12 July 2018

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A tumorigenic subpopulation with stem cell properties in melanomas

12 July 2018

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12 July 2018

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The RAS/RAF/MEK/ERK and PI3K/AKT signaling pathways present molecular targets for the effective treatment of advanced melanoma

12 July 2018

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12 July 2018

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Pax3 functions at a nodal point in melanocyte stem cell differentiation

12 July 2018

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In vivo inhibition of endogenous brain tumors through systemic interference of Hedgehog signaling in mice.

12 July 2018

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Sonic hedgehog controls stem cell behavior in the postnatal and adult brain

12 July 2018

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Deregulated Akt3 activity promotes development of malignant melanoma

12 July 2018

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Hedgehog signalling in prostate regeneration, neoplasia and metastasis

12 July 2018

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Inhibition of prostate cancer proliferation by interference with SONIC HEDGEHOG-GLI1 signaling

12 July 2018

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Expression of the PTCH1 tumor suppressor gene is regulated by alternative promoters and a single functional Gli-binding site

12 July 2018

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Bmi1 is essential for cerebellar development and is overexpressed in human medulloblastomas

12 July 2018

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Multipotentiality of the neural crest

12 July 2018

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Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis

12 July 2018

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MLANA/MART1 and SILV/PMEL17/GP100 are transcriptionally regulated by MITF in melanocytes and melanoma

12 July 2018

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Microphthalamia-associated transcription factor: a critical regulator of pigment cell development and survival.

12 July 2018

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FOXM1 is a downstream target of Gli1 in basal cell carcinomas

12 July 2018

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Bcl2 regulation by the melanocyte master regulator Mitf modulates lineage survival and melanoma cell viability

12 July 2018

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12 July 2018

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The melanocyte-specific isoform of the microphthalmia transcription factor affects the phenotype of human melanoma

12 July 2018

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The Sonic Hedgehog-Gli pathway regulates dorsal brain growth and tumorigenesis

12 July 2018

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Gene expression profiling leads to identification of GLI1-binding elements in target genes and a role for multiple downstream pathways in GLI1-induced cell transformation

12 July 2018

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12 July 2018

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Gli2 functions in FGF signaling during antero-posterior patterning

12 July 2018

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The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes

12 July 2018

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Relative reciprocity of NRAS and PTEN/MMAC1 alterations in cutaneous melanoma cell lines.

12 July 2018

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Mammalian suppressor-of-fused modulates nuclear-cytoplasmic shuttling of Gli-1

12 July 2018

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Overexpression of mutant ras in human melanoma increases invasiveness, proliferation and anchorage-independent growth in vitro and induces tumour formation and cachexia in vivo

12 July 2018

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12 July 2018

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12 July 2018

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Sonic hedgehog regulates the growth and patterning of the cerebellum

12 July 2018

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12 July 2018

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Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours

12 July 2018

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Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

12 July 2018

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Expression of the neuroectodermal intermediate filament nestin in human melanomas.

12 July 2018

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12 July 2018

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Hair follicle renewal: organization of stem cells in the matrix and the role of stereotyped lineages and behaviors

25 September 2018

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Hedgehog-GLI signaling regulates the behavior of cells with stem cell properties in the developing neocortex.

25 September 2018

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Dominant role of the niche in melanocyte stem-cell fate determination

25 September 2018

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Crossref

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Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61Kon an INK4a-Deficient Background

21 January 2018

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Crossref

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21 January 2018

Identifiers

DOI

10.1073/PNAS.0700776104

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17392427%20AND%20SRC:MED&resulttype=core&format=json

28 December 2019

0 references

1 reference

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28 December 2019

PubMed publication ID

17392427

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17392427%20AND%20SRC:MED&resulttype=core&format=json