Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter (Q35914666)

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scientific article published on 3 July 2015

Language	Label	Description	Also known as
English	Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter	scientific article published on 3 July 2015

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Deregulation of NR2E3, an orphan nuclear receptor, by benzo(a)pyrene-induced oxidative stress is associated with histone modification status change of the estrogen receptor gene promoter (English)

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

0 references

author name string

Tilak Khanal

1

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Dasom Kim

2

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Abby Johnson

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Divaker Choubey

4

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Kyounghyun Kim

5

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

publication date

3 July 2015

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

Toxicology Letters

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

237

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

228-236

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

In pursuit of synthetic modulators for the orphan retina-specific nuclear receptor NR2E3

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524348

27 July 2018

Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524348

27 July 2018

Orphan nuclear receptor PNR/NR2E3 stimulates p53 functions by enhancing p53 acetylation

1 reference

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27 July 2018

Inhibitory effects of chrysoeriol on DNA adduct formation with benzo[a]pyrene in MCF-7 breast cancer cells

1 reference

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27 July 2018

NR2E3 mutations in enhanced S-cone sensitivity syndrome (ESCS), Goldmann-Favre syndrome (GFS), clumped pigmentary retinal degeneration (CPRD), and retinitis pigmentosa (RP).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524348

27 July 2018

Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?

1 reference

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27 July 2018

Genome-wide H3K9 histone acetylation profiles are altered in benzopyrene-treated MCF7 breast cancer cells

1 reference

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27 July 2018

The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes

1 reference

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27 July 2018

The rod photoreceptor-specific nuclear receptor Nr2e3 represses transcription of multiple cone-specific genes.

1 reference

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27 July 2018

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

1 reference

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27 July 2018

Photoreceptor-specific nuclear receptor NR2E3 functions as a transcriptional activator in rod photoreceptors

1 reference

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27 July 2018

ROS stress in cancer cells and therapeutic implications

1 reference

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27 July 2018

Benzo(a)pyrene quinones increase cell proliferation, generate reactive oxygen species, and transactivate the epidermal growth factor receptor in breast epithelial cells

1 reference

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27 July 2018

Shared mutations in NR2E3 in enhanced S-cone syndrome, Goldmann-Favre syndrome, and many cases of clumped pigmentary retinal degeneration

1 reference

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27 July 2018

A deletion in a photoreceptor-specific nuclear receptor mRNA causes retinal degeneration in the rd7 mouse

1 reference

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Genotoxic polycyclic aromatic hydrocarbon ortho-quinones generated by aldo-keto reductases induce CYP1A1 via nuclear translocation of the aryl hydrocarbon receptor

1 reference

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Risk of premenopausal breast cancer in association with occupational exposure to polycyclic aromatic hydrocarbons and benzene

1 reference

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27 July 2018

Estrogen receptor status by immunohistochemistry is superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524348

27 July 2018

Identification of a photoreceptor cell-specific nuclear receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524348

27 July 2018

Isoform-specific induction of a human aldo-keto reductase by polycyclic aromatic hydrocarbons (PAHs), electrophiles, and oxidative stress: implications for the alternative pathway of PAH activation catalyzed by human dihydrodiol dehydrogenase.

1 reference

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27 July 2018

Prognostic and predictive factors in breast cancer by immunohistochemical analysis

1 reference

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27 July 2018

Cancer risk from occupational and environmental exposure to polycyclic aromatic hydrocarbons

1 reference

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27 July 2018

Expression of cytochromes P450 in human breast tissue and tumors

1 reference

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27 July 2018

Loss of estrogen receptor in recurrent breast cancer is associated with poor response to endocrine therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4524348

27 July 2018

A randomized clinical trial evaluating tamoxifen in the treatment of patients with node-negative breast cancer who have estrogen-receptor-positive tumors

1 reference

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27 July 2018

Chronic exposure to combined carcinogens enhances breast cell carcinogenesis with mesenchymal and stem-like cell properties

1 reference

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24 September 2018

The Crystal Structure of the Orphan Nuclear Receptor NR2E3/PNR Ligand Binding Domain Reveals a Dimeric Auto-Repressed Conformation

1 reference

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Benzo[a]pyrene sensitizes MCF7 breast cancer cells to induction of G1 arrest by the natural flavonoid eupatorin-5-methyl ether, via activation of cell signaling proteins and CYP1-mediated metabolism.

1 reference

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Reactivation of L1 retrotransposon by benzo(a)pyrene involves complex genetic and epigenetic regulation

1 reference

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Lysine-specific demethylase 1 (LSD1) is highly expressed in ER-negative breast cancers and a biomarker predicting aggressive biology

1 reference

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24 September 2018

Phenotypic features of patients with NR2E3 mutations.

1 reference

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Dual role of Nr2e3 in photoreceptor development and maintenance

1 reference

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24 September 2018

The Gly56Arg mutation in NR2E3 accounts for 1-2% of autosomal dominant retinitis pigmentosa

1 reference

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Gene expression and benefit of chemotherapy in women with node-negative, estrogen receptor-positive breast cancer

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Tobacco smoke carcinogens and breast cancer

1 reference

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24 September 2018

The nuclear receptor NR2E3 plays a role in human retinal photoreceptor differentiation and degeneration

1 reference

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Sensitivity to benzo(a)pyrene diol-epoxide associated with risk of breast cancer in young women and modulation by glutathione S-transferase polymorphisms: a case-control study.

1 reference

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Methylated CpG dinucleotides are the preferential targets for G-to-T transversion mutations induced by benzo[a]pyrene diol epoxide in mammalian cells: similarities with the p53 mutation spectrum in smoking-associated lung cancers.

1 reference

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Excess cone cell proliferation due to lack of a functional NR2E3 causes retinal dysplasia and degeneration in rd7/rd7 mice

1 reference

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Modulation of gene expression and endocrine response pathways by 2,3,7,8-tetrachlorodibenzo-p-dioxin and related compounds

1 reference

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Benzo[alpha]pyrene metabolism, activation and carcinogenesis: role and regulation of mixed-function oxidases and related enzymes

1 reference

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Metabolism of polycyclic aromatic hydrocarbons: etiologic role in carcinogenesis

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Induction of transformation and continuous cell lines from normal human mammary epithelial cells after exposure to benzo[a]pyrene

1 reference

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Mutagenicity studies of different polycyclic aromatic hydrocarbons: the significance of enzymatic factors and molecular structure

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Methylation of the estrogen receptor gene CpG island marks loss of estrogen receptor expression in human breast cancer cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26149760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aromatic DNA adducts in adjacent tissues of breast cancer patients: clues to breast cancer etiology

1 reference

https://pubmed.ncbi.nlm.nih.gov/26149760

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.TOXLET.2015.06.1708

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

11 August 2017

ResearchGate publication ID

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