TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity (Q35904627)

11 August 2017

TOPBP1 regulates RAD51 phosphorylation and chromatin loading and determines PARP inhibitor sensitivity (English)

1 reference

11 August 2017

1 reference

Jiri Bartek

0 references

Jiří Lukáš

object named as

Jiri Lukas

0 references

Pavel Moudrý

object named as

Pavel Moudry

0 references

Vibe H Oestergaard

0 references

Fumiko Esashi

0 references

Apolinar Maya-Mendoza

object named as

Apolinar Maya-Mendoza

0 references

Michael Lisby

0 references

Sugiko Watanabe

0 references

Jirina Bartkova

1 reference

11 August 2017

Pavel Moudry

1 reference

11 August 2017

Kenji Watanabe

1 reference

11 August 2017

Kamila M Wolanin

1 reference

11 August 2017

Isabel E Wassing

1 reference

11 August 2017

Robert Strauss

1 reference

11 August 2017

Rune Troelsgaard Pedersen

1 reference

11 August 2017

Miguel Andújar-Sánchez

1 reference

11 August 2017

language of work or name

English

0 references

publication date

25 January 2016

1 reference

11 August 2017

1 reference

inferred from page(s)

published in

Journal of Cell Biology

1 reference

11 August 2017

212

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11 August 2017

1 reference

11 August 2017

281-288

1 reference

PLK1-dependent activation of LRRK1 regulates spindle orientation by phosphorylating CDK5RAP2.

11 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Complementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

BRCA2 diffuses as oligomeric clusters with RAD51 and changes mobility after DNA damage in live cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Synthetic lethality and cancer therapy: lessons learned from the development of PARP inhibitors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Structure and mechanism of action of the BRCA2 breast cancer tumor suppressor

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

BRCA2 coordinates the activities of cell-cycle kinases to promote genome stability

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Akt switches TopBP1 function from checkpoint activation to transcriptional regulation through phosphoserine binding-mediated oligomerization

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

On PAR with PARP: cellular stress signaling through poly(ADP-ribose) and PARP-1.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Tracking genome engineering outcome at individual DNA breakpoints

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Structure and function of the Rad9-binding region of the DNA-damage checkpoint adaptor TopBP1

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Function of TopBP1 in genome stability

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

The DNA-damage response in human biology and disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

PALB2 is an integral component of the BRCA complex required for homologous recombination repair

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

TopBP1 activates ATR through ATRIP and a PIKK regulatory domain

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

ATR signaling can drive cells into senescence in the absence of DNA breaks

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Aberrant expression of TopBP1 in breast cancer.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

TopBP1 activates the ATR-ATRIP complex

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

A DNA-topoisomerase-II-binding protein with eight repeating regions similar to DNA-repair enzymes and to a cell-cycle regulator

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

Activity of the clinical-stage CK2-specific inhibitor CX-4945 against chronic lymphocytic leukemia.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

TopBP1 associates with NBS1 and is involved in homologous recombination repair.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4748576

BRCA2 is required for ionizing radiation-induced assembly of Rad51 complex in vivo

24 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26811421

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.201507042

1 reference

11 August 2017

1 reference

11 August 2017

PubMed publication ID

26811421

1 reference