A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosides (Q35879410)

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scientific article published in March 1997

Language	Label	Description	Also known as
English	A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosides	scientific article published in March 1997

Statements

scholarly article

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosides (English)

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

feline immunodeficiency virus

object named as

feline immunodeficiency virus

1 reference

based on heuristic

inferred from title

author name string

R A Smith

1

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

K M Remington

2

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

R M Lloyd

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

R F Schinazi

4

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

T W North

5

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

language of work or name

0 references

publication date

1 March 1997

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

number of pages

6

1 reference

based on heuristic

inferred from page(s)

Journal of Virology

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

71

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

3

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

2357-2362

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

Mutants of feline immunodeficiency virus resistant to 2',3'-dideoxy-2',3'-didehydrothymidine

1 reference

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Selection and characterization of a mutant of feline immunodeficiency virus resistant to 2',3'-dideoxycytidine

1 reference

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The mutation frequency of feline immunodeficiency virus enhanced by 3'-azido-3'-deoxythymidine

1 reference

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11 July 2018

The same mutation that encodes low-level human immunodeficiency virus type 1 resistance to 2',3'-dideoxyinosine and 2',3'-dideoxycytidine confers high-level resistance to the (-) enantiomer of 2',3'-dideoxy-3'-thiacytidine

1 reference

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Generation of drug-resistant variants of human immunodeficiency virus type 1 by in vitro passage in increasing concentrations of 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

1 reference

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In vitro isolation and identification of human immunodeficiency virus (HIV) variants with reduced sensitivity to C-2 symmetrical inhibitors of HIV type 1 protease

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Resistance of clinical isolates of human immunodeficiency virus to antiretroviral agents

1 reference

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Selection of multiple human immunodeficiency virus type 1 variants that encode viral proteases with decreased sensitivity to an inhibitor of the viral protease

1 reference

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Combination therapy with zidovudine and didanosine selects for drug-resistant human immunodeficiency virus type 1 strains with unique patterns of pol gene mutations.

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Anti-human immunodeficiency virus activities of the beta-L enantiomer of 2',3'-dideoxycytidine and its 5-fluoro derivative in vitro

1 reference

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Multiple-drug-resistant mutants of feline immunodeficiency virus selected with 2',3'-dideoxyinosine alone and in combination with 3'-azido-3'-deoxythymidine

1 reference

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Characterization of human immunodeficiency virus type 1 mutants with decreased sensitivity to proteinase inhibitor Ro 31-8959.

1 reference

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A phase I/II study of 2'-deoxy-3'-thiacytidine (lamivudine) in patients with advanced human immunodeficiency virus infection

1 reference

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In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

1 reference

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11 July 2018

Rapid in vitro selection of human immunodeficiency virus type 1 resistant to 3'-thiacytidine inhibitors due to a mutation in the YMDD region of reverse transcriptase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191345

11 July 2018

Characterization of human immunodeficiency viruses resistant to oxathiolane-cytosine nucleosides

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191345

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Clinical correlates and molecular basis of HIV drug resistance

1 reference

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Potential mechanism for sustained antiretroviral efficacy of AZT-3TC combination therapy

1 reference

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11 July 2018

Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs

1 reference

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11 July 2018

Expression of reverse transcriptase from feline immunodeficiency virus in Escherichia coli

1 reference

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11 July 2018

Identification of a mutation at codon 65 in the IKKK motif of reverse transcriptase that encodes human immunodeficiency virus resistance to 2',3'-dideoxycytidine and 2',3'-dideoxy-3'-thiacytidine

1 reference

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Nevirapine resistance mutations of human immunodeficiency virus type 1 selected during therapy

1 reference

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Rapid phenotypic reversion of zidovudine-resistant feline immunodeficiency virus without loss of drug-resistant reverse transcriptase

1 reference

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High-level resistance to (-) enantiomeric 2'-deoxy-3'-thiacytidine in vitro is due to one amino acid substitution in the catalytic site of human immunodeficiency virus type 1 reverse transcriptase

1 reference

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Isolation of a T-lymphotropic virus from domestic cats with an immunodeficiency-like syndrome

1 reference

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Nucleotide sequence analysis of feline immunodeficiency virus: genome organization and relationship to other lentiviruses

1 reference

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Nucleotide sequence and genomic organization of feline immunodeficiency virus

1 reference

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Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

1 reference

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Feline immunodeficiency virus, a model for reverse transcriptase-targeted chemotherapy for acquired immune deficiency syndrome

1 reference

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HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy

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Pathogenesis of experimentally induced feline immunodeficiency virus infection in cats.

1 reference

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Immunologic abnormalities in pathogen-free cats experimentally infected with feline immunodeficiency virus

1 reference

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Mutants of feline immunodeficiency virus resistant to 3'-azido-3'-deoxythymidine

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=191345

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In vitro selection of variants of human immunodeficiency virus type 1 resistant to 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosine

1 reference

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Resistance to ddI and sensitivity to AZT induced by a mutation in HIV-1 reverse transcriptase

1 reference

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Zidovudine-resistant human immunodeficiency virus selected by passage in cell culture

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HIV-1 Reverse Transcriptase: Structure Predictions for the Polymerase Domain

1 reference

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Direct comparisons of inhibitor sensitivities of reverse transcriptases from feline and human immunodeficiency viruses

1 reference

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Characterization of reverse transcriptase from feline immunodeficiency virus

1 reference

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1 reference

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1 reference

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1 reference

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HIV inhibitors targeted at the reverse transcriptase

1 reference

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Human immunodeficiency virus type 1 pol gene mutations which cause decreased susceptibility to 2',3'-dideoxycytidine

1 reference

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Selective inhibition of human immunodeficiency viruses by racemates and enantiomers of cis-5-fluoro-1-[2-(hydroxymethyl)-1,3-oxathiolan-5-yl]cytosine

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AIDS-associated encephalopathy with experimental feline immunodeficiency virus infection.

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Neurological abnormalities associated with feline immunodeficiency virus infection

1 reference

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Development of clinical disease in cats experimentally infected with feline immunodeficiency virus

1 reference

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Rapid changes in human immunodeficiency virus type 1 RNA load and appearance of drug-resistant virus populations in persons treated with lamivudine (3TC).

1 reference

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Testing anti–HIV drugs in the FIV model

1 reference

https://pubmed.ncbi.nlm.nih.gov/9032372

12 December 2020

based on heuristic

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Enhanced fidelity of 3TC-selected mutant HIV-1 reverse transcriptase

1 reference

https://pubmed.ncbi.nlm.nih.gov/9032372

12 December 2020

based on heuristic

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Identifiers

10.1128/JVI.71.3.2357-2362.1997

0 references

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

10 August 2017

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