Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin (Q35799801)

10 August 2017

title

Mitochondrial oxidative stress caused by Sod2 deficiency promotes cellular senescence and aging phenotypes in the skin (English)

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10 August 2017

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Judith Campisi

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10 August 2017

Michael C Velarde

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10 August 2017

James M Flynn

series ordinal

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10 August 2017

Nicholas U Day

series ordinal

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10 August 2017

Simon Melov

series ordinal

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10 August 2017

publication date

1 January 2012

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10 August 2017

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10 August 2017

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10 August 2017

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10 August 2017

page(s)

3-12

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Four faces of cellular senescence

10 August 2017

cites work

1 reference

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Feedback between p21 and reactive oxygen production is necessary for cell senescence

11 July 2018

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Oxygen deprivation inhibits basal keratinocyte proliferation in a model of human skin and induces regio-specific changes in the distribution of epidermal adherens junction proteins, aquaporin-3, and glycogen

11 July 2018

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Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion.

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11 July 2018

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Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence

11 July 2018

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11 July 2018

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Motif module map reveals enforcement of aging by continual NF-kappaB activity

11 July 2018

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11 July 2018

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11 July 2018

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Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence

11 July 2018

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Mitochondrial dysfunction accounts for the stochastic heterogeneity in telomere-dependent senescence

11 July 2018

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The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence.

11 July 2018

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11 July 2018

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Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

11 July 2018

1 reference

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Senescence-associated beta-galactosidase is lysosomal beta-galactosidase

11 July 2018

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The cornified envelope: a model of cell death in the skin

11 July 2018

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Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors

11 July 2018

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Mitochondria, oxidants, and aging

11 July 2018

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Human cell senescence as a DNA damage response.

11 July 2018

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Ink4a/Arf expression is a biomarker of aging

11 July 2018

1 reference

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Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a)

11 July 2018

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Senescence-associated changes in respiration and oxidative phosphorylation in primary human fibroblasts

11 July 2018

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Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

11 July 2018

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11 July 2018

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Oxygen sensitivity severely limits the replicative lifespan of murine fibroblasts

11 July 2018

1 reference

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Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics.

11 July 2018

1 reference

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Mouse models of mitochondrial disease, oxidative stress, and senescence.

11 July 2018

1 reference

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The spatial relationship between stem cells and their progeny in the basal layer of human epidermis: a new view based on whole-mount labelling and lineage analysis

11 July 2018

1 reference

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Mitochondrial disease in superoxide dismutase 2 mutant mice

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Tropospheric ozone: an emerging environmental stress to skin

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Monospecific monoclonal antibodies to keratin 1 carboxy terminal (synthetic peptide) and to keratin 10 as markers of epidermal differentiation

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase

11 July 2018

1 reference

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Calcium regulation of growth and differentiation of mouse epidermal cells in culture

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Role of free radicals in aging and disease

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Aging epidermis is maintained by changes in transit-amplifying cell kinetics, not stem cell kinetics.

11 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Stress-induced responses of human skin fibroblasts in vitro reflect human longevity.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Mitochondrial production of reactive oxygen species: role of complex I and quinone analogues

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

p16INK4A is a robust in vivo biomarker of cellular aging in human skin.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Cellular senescence in aging primates.

25 September 2018

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Induction of apoptosis-like mitochondrial impairment triggers antioxidant and Bcl-2-dependent keratinocyte differentiation

25 September 2018

1 reference

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Endogenous mitochondrial oxidative stress: neurodegeneration, proteomic analysis, specific respiratory chain defects, and efficacious antioxidant therapy in superoxide dismutase 2 null mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Mitochondrial oxidative stress causes chromosomal instability of mouse embryonic fibroblasts

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Senescence-enhanced oxidative stress is associated with deficiency of mitochondrial cytochrome c oxidase in vascular endothelial cells

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Terminal differentiation of human epidermal keratinocytes involves mitochondria- and caspase-dependent cell death pathway.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

Accelerated aging phenotype in mice with conditional deficiency for mitochondrial superoxide dismutase in the connective tissue

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3292901

The effect of age on mitosis in the human epidermis

15 November 2018

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12 December 2020

Isolation and short-term culture of primary keratinocytes, hair follicle populations and dermal cells from newborn mice and keratinocytes from adult mice for in vitro analysis and for grafting to immunodeficient mice

1 reference

12 December 2020

Distinction between differentiation and senescence and the absence of increased apoptosis in human keratinocytes undergoing cellular aging in vitro

1 reference

12 December 2020

DNA damage response and cellular senescence in tissues of aging mice

1 reference

12 December 2020

Human epidermal keratinocytes accumulate superoxide due to low activity of Mn-SOD, leading to mitochondrial functional impairment

1 reference

12 December 2020

Sustained inhibition of oxidative phosphorylation impairs cell proliferation and induces premature senescence in human fibroblasts

1 reference

12 December 2020

Expression of transglutaminase 1 in human epidermis

1 reference

12 December 2020

Identifiers

DOI

10.18632/AGING.100423

0 references

PMC publication ID

3292901

1 reference

10 August 2017

1 reference