Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling (Q34574774)

3 August 2017

title

Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling (English)

1 reference

3 August 2017

Natalia A Riobó

1 reference

3 August 2017

Ke Lu

1 reference

3 August 2017

Xingbin Ai

1 reference

3 August 2017

Gwendolyn M Haines

1 reference

3 August 2017

Charles P Emerson

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3 August 2017

language of work or name

English

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publication date

10 March 2006

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Proceedings of the National Academy of Sciences of the United States of America

3 August 2017

published in

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3 August 2017

volume

103

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3 August 2017

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3 August 2017

page(s)

4505-4510

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Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development

3 August 2017

cites work

1 reference

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Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

7 July 2018

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Hedgehog signalling activity of Smoothened requires phosphorylation by protein kinase A and casein kinase I.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Extensive phosphorylation of Smoothened in Hedgehog pathway activation

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Tissue repair and stem cell renewal in carcinogenesis

7 July 2018

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Sonic hedgehog and insulin-like growth factor signaling synergize to induce medulloblastoma formation from nestin-expressing neural progenitors in mice

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction

7 July 2018

1 reference

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Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase

7 July 2018

1 reference

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Novel genes regulated by Sonic Hedgehog in pluripotent mesenchymal cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Hedgehog signaling in animal development: paradigms and principles

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Peptide and protein library screening defines optimal substrate motifs for AKT/PKB.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Induction of osteogenic differentiation by hedgehog proteins.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Pax6 controls progenitor cell identity and neuronal fate in response to graded Shh signaling

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Hedgehog-regulated Costal2-kinase complexes control phosphorylation and proteolytic processing of Cubitus interruptus.

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Beta-arrestin 2 regulates zebrafish development through the hedgehog signaling pathway

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Hedgehog and PI-3 kinase signaling converge on Nmyc1 to promote cell cycle progression in cerebellar neuronal precursors.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Patched target Igf2 is indispensable for the formation of medulloblastoma and rhabdomyosarcoma.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Analysis of PTEN/MMAC1 alterations in aerodigestive tract tumors

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Antagonizing cAMP-dependent protein kinase A in the dorsal CNS activates a conserved Sonic hedgehog signaling pathway.

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1450201

Pancreatic cancer cell proliferation is phosphatidylinositol 3-kinase dependent

27 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16537363

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

IGFs, insulin, Shh, bFGF, and TGF-beta1 interact synergistically to promote somite myogenesis in vitro

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/16537363

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1073/PNAS.0504337103

1 reference

3 August 2017

0 references

1 reference

3 August 2017

1 reference