The use of genetically modified mice in cancer risk assessment: challenges and limitations. (Q35688431)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23985072%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

title

The use of genetically modified mice in cancer risk assessment: challenges and limitations (English)

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Suryanarayana V. Vulimiri

8 March 2020

author

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8 March 2020

David A Eastmond

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8 March 2020

John E French

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8 March 2020

Babasaheb Sonawane

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8 March 2020

language of work or name

English

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publication date

1 September 2013

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Critical Reviews in Toxicology

8 March 2020

published in

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8 March 2020

volume

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8 March 2020

issue

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8 March 2020

page(s)

611-631

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Risk Assessment in the Federal Government

8 March 2020

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27 July 2018

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27 July 2018

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Chromosome aberrations and telomere length modulation in bone marrow and spleen cells of melphalan-treated p53+/- mice.

27 July 2018

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Mouse skin models for carcinogenic hazard identification: utilities and challenges

27 July 2018

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Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review

27 July 2018

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Use of transgenic mice in carcinogenicity hazard assessment

27 July 2018

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Role of gene knockout and transgenic mice in the study of xenobiotic metabolism

27 July 2018

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Bioassay of p-cresidine for possible carcinogenicity.

27 July 2018

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Toxicology and Carcinogenesis Studies of 4-Vinyl-1-cyclohexene Diepoxide (CAS No. 106-87-6) in F344/N Rats and B6C3F1 Mice (Dermal Studies)

27 July 2018

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27 July 2018

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The Tg.AC (v-Ha-ras) transgenic mouse: nature of the model

27 July 2018

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P53+/- hemizygous knockout mouse: overview of available data

27 July 2018

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The nature of the heterozygous Trp53 knockout model for identification of mutagenic carcinogens

27 July 2018

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A perspective on current and future uses of alternative models for carcinogenicity testing

27 July 2018

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Mechanisms of hormonal carcinogenesis in the p53+/- hemizygous knockout mouse: studies with diethylstilbestrol

27 July 2018

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27 July 2018

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27 July 2018

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Induction and time-dependent accumulation of micronuclei in peripheral blood of transgenic p53+/- mice, Tg.AC (v-Ha-ras) and parental wild-type (C57BL/6 and FVB/N) mice exposed to benzene by inhalation

27 July 2018

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Oral administration of dimethylvinyl chloride increases frequency of forestomach papillomas in Tg.AC mice

27 July 2018

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Loss of heterozygosity frequency at the Trp53 locus in p53-deficient (+/-) mouse tumors is carcinogen-and tissue-dependent

27 July 2018

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Chromosome 11 allelotypes reflect a mechanism of chemical carcinogenesis in heterozygous p53-deficient mice

27 July 2018

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Use of transgenic animals for carcinogenicity testing: considerations and implications for risk assessment

27 July 2018

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Statistical analysis of skin tumor data from Tg.AC mouse bioassays

27 July 2018

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Current status and use of short/medium-term models for assessment of carcinogenicity of human pharmaceuticals: regulatory perspectives

27 July 2018

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Responses of transgenic mouse lines p53(+/-) and Tg.AC to agents tested in conventional carcinogenicity bioassays

27 July 2018

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The p53 heterozygous knockout mouse as a model for chemical carcinogenesis in vascular tissue

27 July 2018

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Carcinogenic chemical-response "fingerprint" for male F344 rats exposed to a series of 195 chemicals: implications for predicting carcinogens with transgenic models

27 July 2018

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Utilization of genetically altered animals in the pharmaceutical industry

27 July 2018

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27 July 2018

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27 July 2018

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Validation of transgenic mice harboring the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing

27 July 2018

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27 July 2018

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Carcinogenic responses of transgenic heterozygous p53 knockout mice to inhaled 239PuO2 or metallic beryllium

27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Validation of transgenic mice carrying the human prototype c-Ha-ras gene as a bioassay model for rapid carcinogenicity testing

27 July 2018

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Susceptibility of p53-deficient mice to induction of mesothelioma by crocidolite asbestos fibers

27 July 2018

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Susceptibility of transgenic mice carrying human prototype c-Ha-ras gene in a short-term carcinogenicity study of vinyl carbamate andras gene analyses of the induced tumors

27 July 2018

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27 July 2018

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Identifying potential human carcinogens--the role of genetically altered rodents

27 July 2018

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Reduction of benzene metabolism and toxicity in mice that lack CYP2E1 expression

27 July 2018

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Evaluation of transgenic mouse bioassays for identifying carcinogens and noncarcinogens

27 July 2018

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An empirical examination of factors influencing prediction of carcinogenic hazard across species

27 July 2018

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Chemically induced skin carcinogenesis in a transgenic mouse line (TG.AC) carrying a v-Ha-ras gene

27 July 2018

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Infrequent p53 mutations in 7,12-dimethylbenz[a]anthracene-induced mammary tumors in BALB/c and p53 hemizygous mice.

27 July 2018

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27 July 2018

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Interspecies extrapolation in carcinogenesis: prediction between rats and mice

27 July 2018

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v-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: effects of phorbol esters and retinoic acid

27 July 2018

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A genetic model for colorectal tumorigenesis

27 July 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

27 July 2018

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Medium-term bioassays for carcinogens

27 July 2018

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A continuum model for tumour suppression

27 July 2018

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Manipulating the germline: its impact on the study of carcinogenesis

21 January 2018

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Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC.

21 January 2018

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The p53-deficient mouse: a model for basic and applied cancer studies

21 January 2018

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Panel discussion: alternative mouse models for carcinogenicity assessment

21 January 2018

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Mode of action considerations in the use of transgenic animals for mutagenicity and carcinogenicity evaluations.

21 January 2018

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Cancer risk assessment approaches at the FDA/CDER: Is the era of the 2-year bioassay drawing to a close?

21 January 2018

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Human p53 knock-in (hupki) mice do not differ in liver tumor response from their counterparts with murine p53.

21 January 2018

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Benzene-induced hematopoietic neoplasms including myeloid leukemia in Trp53-deficient C57BL/6 and C3H/He mice

21 January 2018

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Knock-in mice with a chimeric human/murine p53 gene develop normally and show wild-type p53 responses to DNA damaging agents: a new biomedical research tool.

21 January 2018

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RAS oncogenes: the first 30 years.

21 January 2018

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Interlaboratory comparison of the CB6F1-Tg rasH2 rapid carcinogenicity testing model.

21 January 2018

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Environmental carcinogens and p53 tumor-suppressor gene interactions in a transgenic mouse model for mammary carcinogenesis

21 January 2018

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Pathological features of spontaneous and induced tumors in transgenic mice carrying a human prototype c-Ha-ras gene used for six-month carcinogenicity studies.

21 January 2018

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Exposure of Tg.AC transgenic mice to benzene suppresses hematopoietic progenitor cells and alters gene expression in critical signaling pathways

21 January 2018

1 reference

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Susceptibilities of p53 knockout and rasH2 transgenic mice to urethane-induced lung carcinogenesis are inherited from their original strains

21 January 2018

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Gene expression profiling of p53(+/-) knockout and wild-type mice following diethylstilbestrol administration

21 January 2018

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Comparative xenobiotic metabolism between Tg.AC and p53+/- genetically altered mice and their respective wild types

21 January 2018

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New models for assessing carcinogenesis: an ongoing process

21 January 2018

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Dermal carcinogenicity in transgenic mice: effect of vehicle on responsiveness of hemizygous Tg.AC mice to phorbol 12-myristate 13-acetate (TPA).

21 January 2018

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Identifying chemical carcinogens and assessing potential risk in short-term bioassays using transgenic mouse models

21 January 2018

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An evaluation of the hemizygous transgenic Tg.AC mouse for carcinogenicity testing of pharmaceuticals. II. A genotypic marker that predicts tumorigenic responsiveness.

21 January 2018

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High susceptibility of human c-Ha-ras proto-oncogene transgenic rats to carcinogenesis: a cancer-prone animal model.

21 January 2018

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Mammary tumor induction and premature ovarian failure in ApcMin mice are not enhanced by Brca2 deficiency

21 January 2018

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Transgenic mouse models for the identification of human carcinogens: a European perspective.

21 January 2018

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Is p53 haploinsufficient for tumor suppression? Implications for the p53+/- mouse model in carcinogenicity testing

21 January 2018

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Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23985072%20AND%20SRC:MED&resulttype=core&format=json

release_pfjoccfzfjfxjaazyj2aomqkoe

8 March 2020

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/pfjoccfzfjfxjaazyj2aomqkoe

24 November 2022

mapped directly with Wikidata item

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23985072%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

PubMed publication ID

23985072

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23985072%20AND%20SRC:MED&resulttype=core&format=json