Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression (Q35676910)

9 August 2017

title

Distinct p53 transcriptional programs dictate acute DNA-damage responses and tumor suppression (English)

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9 August 2017

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Stephano S Mello

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Colleen A Brady

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9 August 2017

Dadi Jiang

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9 August 2017

Thomas M Johnson

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9 August 2017

Lesley A Jarvis

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9 August 2017

Margaret M Kozak

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9 August 2017

Daniela Kenzelmann Broz

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9 August 2017

Shashwati Basak

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9 August 2017

Eunice J Park

1 reference

9 August 2017

Margaret E McLaughlin

1 reference

9 August 2017

Anthony N Karnezis

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9 August 2017

Laura D Attardi

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9 August 2017

language of work or name

English

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publication date

1 May 2011

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9 August 2017

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9 August 2017

volume

145

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9 August 2017

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9 August 2017

page(s)

571-583

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SID1 transmembrane family, member 2 (Sidt2): A novel lysosomal membrane protein

9 August 2017

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12 July 2018

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Multivalent binding of p53 to the STAGA complex mediates coactivator recruitment after UV damage

12 July 2018

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12 July 2018

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Four domains of p300 each bind tightly to a sequence spanning both transactivation subdomains of p53

12 July 2018

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Restoration of p53 function leads to tumour regression in vivo

12 July 2018

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p21 delays tumor onset by preservation of chromosomal stability

12 July 2018

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Keeping transcriptional activators under control

12 July 2018

1 reference

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The pathological response to DNA damage does not contribute to p53-mediated tumour suppression

12 July 2018

1 reference

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12 July 2018

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Plasminogen activator inhibitor-1 is a critical downstream target of p53 in the induction of replicative senescence

12 July 2018

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Lessons from p53 in non-mammalian models.

12 July 2018

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A global map of p53 transcription-factor binding sites in the human genome

12 July 2018

1 reference

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Structural details on mdm2-p53 interaction

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

An expression signature for p53 status in human breast cancer predicts mutation status, transcriptional effects, and patient survival

12 July 2018

1 reference

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RNA interference: a mammalian SID-1 homologue enhances siRNA uptake and gene silencing efficacy in human cells

12 July 2018

1 reference

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What have animal models taught us about the p53 pathway?

12 July 2018

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Suppression of tumorigenesis by the p53 target PUMA

12 July 2018

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PML is a direct p53 target that modulates p53 effector functions

12 July 2018

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Perp is a mediator of p53-dependent apoptosis in diverse cell types

12 July 2018

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Cloning and characterization of mCRIP2, a mouse LIM-only protein that interacts with PDZ domain IV of PTP-BL

12 July 2018

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The role of p53 in determining sensitivity to radiotherapy

12 July 2018

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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras

12 July 2018

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Somatic activation of the K-ras oncogene causes early onset lung cancer in mice

12 July 2018

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Significance analysis of microarrays applied to the ionizing radiation response

12 July 2018

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12 July 2018

Surfing the p53 network

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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

12 July 2018

1 reference

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PML is induced by oncogenic ras and promotes premature senescence

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

Identification of a novel p53 functional domain that is necessary for mediating apoptosis

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

Bypass of Senescence After Disruption of p21 CIP1/WAF1 Gene in Normal Diploid Human Fibroblasts

12 July 2018

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Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

12 July 2018

1 reference

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p53 is required for radiation-induced apoptosis in mouse thymocytes

12 July 2018

1 reference

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The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

12 July 2018

1 reference

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Transcription activity is required for p53-dependent tumor suppression

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

Genetic dissection of the role of p21Cip1/Waf1 in p53-mediated tumour suppression.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

Tumour biology: Policing of oncogene activity by p53

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3259909

The differential effects of mutant p53 alleles on advanced murine lung cancer

15 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21565614

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Two tandem and independent sub-activation domains in the amino terminus of p53 require the adaptor complex for activity

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21565614

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1016/J.CELL.2011.03.035

1 reference

9 August 2017

1 reference

9 August 2017

1 reference