The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality (Q46111122)

19 December 2017

title

The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality (English)

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19 December 2017

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Amato Giaccia

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19 December 2017

author name string

Thomas M Johnson

series ordinal

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19 December 2017

Ester M Hammond

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19 December 2017

Laura D Attardi

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19 December 2017

language of work or name

English

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publication date

16 January 2005

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19 December 2017

published in

Nature Genetics

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19 December 2017

volume

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19 December 2017

issue

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19 December 2017

page(s)

145-152

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19 December 2017

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

cites work

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Tumor spectrum analysis in p53-mutant mice

21 January 2018

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WAF1, a potential mediator of p53 tumor suppression

21 January 2018

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Radiation-induced cell cycle arrest compromised by p21 deficiency

21 January 2018

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Mice Lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control

21 January 2018

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Live or let die: the cell's response to p53

21 January 2018

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Essential role for p53-mediated transcription in E1A-induced apoptosis

21 January 2018

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bax-deficiency promotes drug resistance and oncogenic transformation by attenuating p53-dependent apoptosis

21 January 2018

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Perp is a mediator of p53-dependent apoptosis in diverse cell types

21 January 2018

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Bax-deficient mice with lymphoid hyperplasia and male germ cell death

21 January 2018

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Integral role of Noxa in p53-mediated apoptotic response

21 January 2018

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p53-dependent apoptosis in the absence of transcriptional activation of p53-target genes

21 January 2018

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Myc-mediated apoptosis requires wild-type p53 in a manner independent of cell cycle arrest and the ability of p53 to induce p21waf1/cip1.

21 January 2018

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Induction of apoptosis in HeLa cells by trans-activation-deficient p53

21 January 2018

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p53 has a direct apoptogenic role at the mitochondria

21 January 2018

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The codon 72 polymorphic variants of p53 have markedly different apoptotic potential

21 January 2018

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Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis

21 January 2018

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

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The alpha-helical FXXPhiPhi motif in p53: TAF interaction and discrimination by MDM2

21 January 2018

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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Mono- versus polyubiquitination: differential control of p53 fate by Mdm2.

21 January 2018

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Differential activation of target cellular promoters by p53 mutants with impaired apoptotic function

21 January 2018

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A mutant p53 that discriminates between p53-responsive genes cannot induce apoptosis

21 January 2018

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A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

21 January 2018

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Activation of the p53-dependent G1 checkpoint response in mouse embryo fibroblasts depends on the specific DNA damage inducer

21 January 2018

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Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis

21 January 2018

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Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition.

21 January 2018

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Hypoxia links ATR and p53 through replication arrest

21 January 2018

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p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage

21 January 2018

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Identification of a novel p53 functional domain that is necessary for mediating apoptosis

21 January 2018

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Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains

21 January 2018

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Suppression of tumorigenesis by the p53 target PUMA

21 January 2018

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Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

21 January 2018

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A transcriptional activation function of p53 is dispensable for and inhibitory of its apoptotic function

21 January 2018

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Placental cell fates are regulated in vivo by HIF-mediated hypoxia responses

21 January 2018

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A transactivation-deficient mouse model provides insights into Trp53 regulation and function

21 January 2018

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

21 January 2018

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Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects.

21 January 2018

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p53 and DNA damage-inducible expression of the xeroderma pigmentosum group C gene

21 January 2018

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p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells

21 January 2018

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7 January 2021

Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits

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7 January 2021

Glucose metabolism in separated embryos and investing membranes during organogenesis in the rat

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7 January 2021

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

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7 January 2021

Identifiers

DOI

10.1038/NG1498

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19 December 2017

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19 December 2017