Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation (Q35663953)

9 August 2017

title

Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation (English)

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9 August 2017

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Jesper Mosolff Mathiesen

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Trond Ulven

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Lena Uller

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9 August 2017

Lisa Alenmyr

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9 August 2017

Magnus Korsgren

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9 August 2017

Thomas Högberg

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9 August 2017

Gunnar Andersson

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9 August 2017

Carl G A Persson

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9 August 2017

Evi Kostenis

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9 August 2017

publication date

28 February 2007

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9 August 2017

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9 August 2017

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9 August 2017

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Resolution of airway disease: removal of inflammatory cells through apoptosis, egression or both?

9 August 2017

cites work

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5. IgE, mast cells, basophils, and eosinophils

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27 July 2018

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Prostaglandin D2 induces chemotaxis in eosinophils via its receptor CRTH2 and eosinophils may cause severe ocular inflammation in patients with allergic conjunctivitis

27 July 2018

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Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse

27 July 2018

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Structural determinants of arylacetic acid nonsteroidal anti-inflammatory drugs necessary for binding and activation of the prostaglandin D2 receptor CRTH2.

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27 July 2018

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11-Dehydro-thromboxane B2, a stable thromboxane metabolite, is a full agonist of chemoattractant receptor-homologous molecule expressed on TH2 cells (CRTH2) in human eosinophils and basophils

27 July 2018

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Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine

27 July 2018

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An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2-induced eosinophil migration in vitro

27 July 2018

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27 July 2018

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27 July 2018

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Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP

27 July 2018

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Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2

27 July 2018

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Allergic lung responses are increased in prostaglandin H synthase-deficient mice.

27 July 2018

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The effect of ramatroban (BAY u 3405), a thromboxane A2 receptor antagonist, on nasal cavity volume and minimum cross-sectional area and nasal mucosal hemodynamics after nasal mucosal allergen challenge in patients with perennial allergic rhinitis

27 July 2018

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27 July 2018

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27 July 2018

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Differential antagonism of airway contractile responses to prostaglandin (PG)D2 and 9 alpha, 11 beta-PGF2 by atropine, SK&F 88046 and SQ 29,548 in the guinea pig.

27 July 2018

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27 July 2018

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27 July 2018

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The effects of an oral thromboxane TP receptor antagonist BAY u 3405, on prostaglandin D2- and histamine-induced bronchoconstriction in asthma, and relationship to plasma drug concentrations

27 July 2018

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Prostaglandin D2 plays an essential role in chronic allergic inflammation of the skin via CRTH2 receptor.

27 July 2018

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25 September 2018

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On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2

25 September 2018

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Minor structural modifications convert the dual TP/CRTH2 antagonist ramatroban into a highly selective and potent CRTH2 antagonist

25 September 2018

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25 September 2018

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Effects of prostaglandin D2, 15-deoxy-Delta12,14-prostaglandin J2, and selective DP1 and DP2 receptor agonists on pulmonary infiltration of eosinophils in Brown Norway rats

25 September 2018

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Prostaglandin D2-induced eosinophilic airway inflammation is mediated by CRTH2 receptor

25 September 2018

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A critical role for eosinophils in allergic airways remodeling

25 September 2018

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Defining a link with asthma in mice congenitally deficient in eosinophils.

25 September 2018

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Differential modulation of human basophil functions through prostaglandin D2 receptors DP and chemoattractant receptor-homologous molecule expressed on Th2 cells/DP2.

25 September 2018

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Chemoattractant receptor-homologous molecule expressed on Th2 cells activation in vivo increases blood leukocyte counts and its blockade abrogates 13,14-dihydro-15-keto-prostaglandin D2-induced eosinophilia in rats

25 September 2018

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Delta 12-prostaglandin J2, a plasma metabolite of prostaglandin D2, causes eosinophil mobilization from the bone marrow and primes eosinophils for chemotaxis

25 September 2018

1 reference

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The role of chemical mediators in eosinophil infiltration in allergic rhinitis in mice

25 September 2018

1 reference

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Selective cyclooxygenase-1 and -2 inhibitors each increase allergic inflammation and airway hyperresponsiveness in mice

25 September 2018

1 reference

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Lung tissue eosinophils may be cleared through luminal entry rather than apoptosis: effects of steroid treatment

25 September 2018

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Allergic eosinophil-rich inflammation develops in lungs and airways of B cell-deficient mice

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810525

The effect of a thromboxane A2 receptor antagonist BAY-u-3405 on experimental allergic reactions

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1810525

Prostaglandin D2 generation after activation of rat and human mast cells with anti-IgE.

25 September 2018

1 reference

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Prostaglandin D2 is a potent chemoattractant for human eosinophils that acts via a novel DP receptor

25 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1465-9921-8-16

Cutting edge: chemoattractant receptor-homologous molecule expressed on Th2 cells plays a restricting role on IL-5 production and eosinophil recruitment

21 January 2018

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12 December 2020

Prostaglandin D2 as a mediator of allergic asthma

1 reference

12 December 2020

Effects of thromboxane A2 receptor antagonist (Bay u 3405) on nasal symptoms after antigen challenge in sensitized guinea pigs

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12 December 2020

BAY u3405, a thromboxane A2 antagonist, reduces bronchial hyperresponsiveness in asthmatics

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12 December 2020

IL-5 secretion by allergen-stimulated CD4+ T cells in primary culture: Relationship to expression of allergic disease

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12 December 2020

Identifiers

DOI

10.1186/1465-9921-8-16

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Dimensions Publication ID

9 August 2017

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1 reference

9 August 2017

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