More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signature (Q35646770)

9 August 2017

title

More complete gene silencing by fewer siRNAs: transparent optimized design and biophysical signature (English)

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9 August 2017

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Istvan Ladunga

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9 August 2017

language of work or name

English

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publication date

14 December 2006

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9 August 2017

published in

Nucleic Acids Research

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

433-440

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Physicochemical descriptors to discriminate protein-protein interactions in permanent and transient complexes selected by means of machine learning algorithms

9 August 2017

cites work

1 reference

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Efficient prediction of siRNAs with siRNArules 1.0: an open-source JAVA approach to siRNA algorithms

12 July 2018

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Prediction of RNA secondary structure by free energy minimization

12 July 2018

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Computational models with thermodynamic and composition features improve siRNA design

12 July 2018

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Thermodynamics of RNA-RNA binding

12 July 2018

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Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes

12 July 2018

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Design of siRNAs producing unstructured guide-RNAs results in improved RNA interference efficiency.

12 July 2018

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Implementing the iHOP concept for navigation of biomedical literature

12 July 2018

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Design of a genome-wide siRNA library using an artificial neural network

12 July 2018

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Mechanistic insights aid computational short interfering RNA design.

12 July 2018

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Profiled support vector machines for antisense oligonucleotide efficacy prediction

12 July 2018

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siRNA Selection Server: an automated siRNA oligonucleotide prediction server

12 July 2018

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Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference

12 July 2018

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Rational siRNA design for RNA interference

12 July 2018

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A statistical sampling algorithm for RNA secondary structure prediction

12 July 2018

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Functional siRNAs and miRNAs Exhibit Strand Bias

12 July 2018

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The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides

12 July 2018

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Expression of small interfering RNAs targeted against HIV-1 rev transcripts in human cells

12 July 2018

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Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysate

12 July 2018

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Statistical prediction of single-stranded regions in RNA secondary structure and application to predicting effective antisense target sites and beyond

12 July 2018

1 reference

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Thermodynamic parameters for an expanded nearest-neighbor model for formation of RNA duplexes with Watson-Crick base pairs

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802606

Constrained optimization and protein structure determination.

12 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802606

Semisupervised learning for molecular profiling

12 July 2018

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A comparison of siRNA efficacy predictors.

25 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802606

Predicting the efficacy of short oligonucleotides in antisense and RNAi experiments with boosted genetic programming.

25 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802606

Improved and automated prediction of effective siRNA.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802606

An algorithm for selection of functional siRNA sequences.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802606

New support vector algorithms

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802606

PHYSEAN: PHYsical SEquence ANalysis for the identification of protein domains on the basis of physical and chemical properties of amino acids.

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802606

A bayesian statistical algorithm for RNA secondary structure prediction

25 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1802606

Concepts to automate the theoretical design of effective antisense oligonucleotides

25 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17169992

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17169992

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1093/NAR/GKL1065

1 reference

9 August 2017

1 reference

9 August 2017

1 reference