Getting to the end: telomerase access in yeast and humans (Q35611361)

9 August 2017

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title

Getting to the end: telomerase access in yeast and humans (English)

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9 August 2017

Maria K Mateyak

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Leticia R Vega

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9 August 2017

Virginia A Zakian

series ordinal

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9 August 2017

publication date

1 December 2003

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Nature Reviews Molecular Cell Biology

9 August 2017

published in

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

948-959

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Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase

9 August 2017

cites work

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Sir proteins, Rif proteins, and Cdc13p bind Saccharomyces telomeres in vivo

31 March 2020

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Est1p as a cell cycle-regulated activator of telomere-bound telomerase

31 March 2020

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The terminal DNA structure of mammalian chromosomes

31 March 2020

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Normal human chromosomes have long G-rich telomeric overhangs at one end

31 March 2020

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Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening

31 March 2020

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A mutant with a defect in telomere elongation leads to senescence in yeast

31 March 2020

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Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint

31 March 2020

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Ten1 functions in telomere end protection and length regulation in association with Stn1 and Cdc13

31 March 2020

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Stn1, a new Saccharomyces cerevisiae protein, is implicated in telomere size regulation in association with Cdc13.

31 March 2020

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TRF2 Protects Human Telomeres from End-to-End Fusions

31 March 2020

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Evidence for a new step in telomere maintenance

31 March 2020

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Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase

31 March 2020

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G-strand overhangs on telomeres in telomerase-deficient mouse cells

31 March 2020

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Strand-Specific Postreplicative Processing of Mammalian Telomeres

31 March 2020

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Accumulation of single-stranded DNA and destabilization of telomeric repeats in yeast mutant strains carrying a deletion of RAD27.

31 March 2020

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Long Telomeric C-rich 5′-Tails in Human Replicating Cells

31 March 2020

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Reverse transcriptase motifs in the catalytic subunit of telomerase

31 March 2020

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Telomerase Catalytic Subunit Homologs from Fission Yeast and Human

31 March 2020

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hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization

31 March 2020

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TLC1: template RNA component of Saccharomyces cerevisiae telomerase

31 March 2020

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The RNA component of human telomerase

31 March 2020

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Telomere maintenance and DNA replication: how closely are these two connected?

31 March 2020

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RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability

31 March 2020

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A human telomeric protein

31 March 2020

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Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2

31 March 2020

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The role of the Mre11-Rad50-Xrs2 complex in telomerase- mediated lengthening of Saccharomyces cerevisiae telomeres

31 March 2020

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Pot1, the putative telomere end-binding protein in fission yeast and humans

31 March 2020

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Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing

31 March 2020

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Mammalian telomeres end in a large duplex loop

31 March 2020

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SIR2 and SIR4 interactions differ in core and extended telomeric heterochromatin in yeast

31 March 2020

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Telomere looping permits gene activation by a downstream UAS in yeast

31 March 2020

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Pif1p helicase, a catalytic inhibitor of telomerase in yeast

31 March 2020

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Multiple pathways cooperate in the suppression of genome instability in Saccharomyces cerevisiae

31 March 2020

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Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy?

31 March 2020

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Human telomerase and its regulation

31 March 2020

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31 March 2020

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Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity

31 March 2020

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Telomere maintenance in fission yeast requires an Est1 ortholog

31 March 2020

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Essential functions of amino-terminal domains in the yeast telomerase catalytic subunit revealed by selection for viable mutants

31 March 2020

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N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo

31 March 2020

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Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization

31 March 2020

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Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase

31 March 2020

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Catalytically active human telomerase mutants with allele-specific biological properties

31 March 2020

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Est1 and Cdc13 as comediators of telomerase access

31 March 2020

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The Est3 protein is a subunit of yeast telomerase

31 March 2020

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Putative Telomere-Recruiting Domain in the Catalytic Subunit of Human Telomerase

31 March 2020

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Protein-DNA interactions in soluble telosomes from Saccharomyces cerevisiae

31 March 2020

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Distortion of the DNA double helix by RAP1 at silencers and multiple telomeric binding sites.

31 March 2020

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The crystal structure of the DNA-binding domain of yeast RAP1 in complex with telomeric DNA

31 March 2020

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Separation of transcriptional activation and silencing functions of the RAP1-encoded repressor/activator protein 1: isolation of viable mutants affecting both silencing and telomere length

31 March 2020

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C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae

31 March 2020

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A protein-counting mechanism for telomere length regulation in yeast.

31 March 2020

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The yeast telomere length counting machinery is sensitive to sequences at the telomere-nontelomere junction.

31 March 2020

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The C Terminus of the Major Yeast Telomere Binding Protein Rap1p Enhances Telomere Formation

31 March 2020

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TRF1 is a dimer and bends telomeric DNA

31 March 2020

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TRF1 binds a bipartite telomeric site with extreme spatial flexibility

31 March 2020

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Targeting assay to study the cis functions of human telomeric proteins: evidence for inhibition of telomerase by TRF1 and for activation of telomere degradation by TRF2

31 March 2020

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Control of telomere length by the human telomeric protein TRF1

31 March 2020

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Control of human telomere length by TRF1 and TRF2

31 March 2020

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hTERT associates with human telomeres and enhances genomic stability and DNA repair

31 March 2020

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Telomere folding is required for the stable maintenance of telomere position effects in yeast

31 March 2020

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A RAP1-interacting protein involved in transcriptional silencing and telomere length regulation

31 March 2020

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A novel Rap1p-interacting factor, Rif2p, cooperates with Rif1p to regulate telomere length in Saccharomyces cerevisiae.

31 March 2020

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Rap1p telomere association is not required for mitotic stability of a C(3)TA(2) telomere in yeast

31 March 2020

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Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae

31 March 2020

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Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process

31 March 2020

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The Pin2/TRF1-interacting protein PinX1 is a potent telomerase inhibitor

31 March 2020

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TIN2, a new regulator of telomere length in human cells

31 March 2020

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Tankyrase, a poly(ADP-ribose) polymerase at human telomeres

31 March 2020

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Ku acts in a unique way at the mammalian telomere to prevent end joining

31 March 2020

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The yeast homolog of human PinX1 is involved in rRNA and small nucleolar RNA maturation, not in telomere elongation inhibition

31 March 2020

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Tankyrase promotes telomere elongation in human cells

31 March 2020

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TRF1 is degraded by ubiquitin-mediated proteolysis after release from telomeres

31 March 2020

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TANK2, a new TRF1-associated poly(ADP-ribose) polymerase, causes rapid induction of cell death upon overexpression

31 March 2020

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31 March 2020

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Identification of human Rap1: implications for telomere evolution

31 March 2020

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Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases

31 March 2020

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Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

31 March 2020

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Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

31 March 2020

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Human werner syndrome DNA helicase unwinds tetrahelical structures of the fragile X syndrome repeat sequence d(CGG)n

31 March 2020

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DNA damage and repair in telomeres: relation to aging

31 March 2020

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Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells

31 March 2020

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SGS1 is required for telomere elongation in the absence of telomerase

31 March 2020

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The Saccharomyces cerevisiae WRN homolog Sgs1p participates in telomere maintenance in cells lacking telomerase

31 March 2020

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Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase

31 March 2020

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The Saccharomyces CDC13 protein is a single-strand TG1-3 telomeric DNA-binding protein in vitro that affects telomere behavior in vivo

31 March 2020

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Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance

31 March 2020

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Cdc13 delivers separate complexes to the telomere for end protection and replication

31 March 2020

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An in vitro assay for saccharomyces telomerase requires EST1

31 March 2020

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Essential regions of Saccharomyces cerevisiae telomerase RNA: separate elements for Est1p and Est2p interaction

31 March 2020

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The Est1 subunit of yeast telomerase binds the Tlc1 telomerase RNA

31 March 2020

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Est1 has the properties of a single-stranded telomere end-binding protein

31 March 2020

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Cell cycle restriction of telomere elongation

31 March 2020

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Telomerase: what are the Est proteins doing?

31 March 2020

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Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends

31 March 2020

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Cdc13 both positively and negatively regulates telomere replication

31 March 2020

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A human homolog of yeast Est1 associates with telomerase and uncaps chromosome ends when overexpressed

31 March 2020

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Functional conservation of the telomerase protein Est1p in humans

31 March 2020

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Analysis of telomerase in Candida albicans: potential role in telomere end protection

31 March 2020

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Telomere proteins: specific recognition and protection of the natural termini of Oxytricha macronuclear DNA

31 March 2020

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Conserved structure for single-stranded telomeric DNA recognition

31 March 2020

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Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA

31 March 2020

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POT1 as a terminal transducer of TRF1 telomere length control

31 March 2020

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Human POT1 facilitates telomere elongation by telomerase

31 March 2020

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Loss of a yeast telomere: arrest, recovery, and chromosome loss.

31 March 2020

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p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2

31 March 2020

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NEJ1 prevents NHEJ-dependent telomere fusions in yeast without telomerase

31 March 2020

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A Ku bridge over broken DNA.

31 March 2020

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Yeast Ku as a regulator of chromosomal DNA end structure

31 March 2020

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The DNA-binding protein Hdf1p (a putative Ku homologue) is required for maintaining normal telomere length in Saccharomyces cerevisiae

31 March 2020

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The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities

31 March 2020

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Identification of a Saccharomyces cerevisiae Ku80 homologue: roles in DNA double strand break rejoining and in telomeric maintenance

31 March 2020

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Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres

31 March 2020

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Telomere maintenance is dependent on activities required for end repair of double-strand breaks

31 March 2020

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The function of a stem-loop in telomerase RNA is linked to the DNA repair protein Ku.

31 March 2020

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Cdc13 cooperates with the yeast Ku proteins and Stn1 to regulate telomerase recruitment

31 March 2020

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Ku is associated with the telomere in mammals

31 March 2020

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Effects of DNA nonhomologous end-joining factors on telomere length and chromosomal stability in mammalian cells

31 March 2020

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Human Ku70/80 associates physically with telomerase through interaction with hTERT

31 March 2020

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DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes

31 March 2020

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Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang

31 March 2020

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Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres

31 March 2020

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The Mre11 complex: at the crossroads of dna repair and checkpoint signalling

31 March 2020

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Mre11 protein complex prevents double-strand break accumulation during chromosomal DNA replication.

31 March 2020

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Alteration of telomeric sequences and senescence caused by mutations in RAD50 of Saccharomyces cerevisiae

31 March 2020

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Components of the Ku-dependent non-homologous end-joining pathway are involved in telomeric length maintenance and telomeric silencing

31 March 2020

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Exonuclease activity is required for sequence addition and Cdc13p loading at a de novo telomere

31 March 2020

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The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance

31 March 2020

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The hMre11/hRad50 protein complex and Nijmegen breakage syndrome: linkage of double-strand break repair to the cellular DNA damage response

31 March 2020

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Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome

31 March 2020

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Two different types of double-strand breaks in Saccharomyces cerevisiae are repaired by similar RAD52-independent, nonhomologous recombination events

31 March 2020

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Repair of chromosome ends after telomere loss in Saccharomyces

31 March 2020

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The saccharomyces PIF1 DNA helicase inhibits telomere elongation and de novo telomere formation

31 March 2020

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A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3' end

31 March 2020

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The nucleolar localization domain of the catalytic subunit of human telomerase

31 March 2020

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Nucleolar localization of hTERT protein is associated with telomerase function

31 March 2020

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A telomerase component is defective in the human disease dyskeratosis congenita

31 March 2020

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In vitro assembly of human H/ACA small nucleolar RNPs reveals unique features of U17 and telomerase RNAs

31 March 2020

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Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10

31 March 2020

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Stable expression in yeast of the mature form of human telomerase RNA depends on its association with the box H/ACA small nucleolar RNP proteins Cbf5p, Nhp2p and Nop10p

31 March 2020

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Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle

31 March 2020

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Intracellular trafficking of yeast telomerase components.

31 March 2020

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Subnuclear shuttling of human telomerase induced by transformation and DNA damage.

31 March 2020

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Telomerase activity in normal and malignant hematopoietic cells

31 March 2020

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Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes

31 March 2020

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Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation

31 March 2020

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Hydrogen peroxide triggers nuclear export of telomerase reverse transcriptase via Src kinase family-dependent phosphorylation of tyrosine 707.

31 March 2020

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Comprehensive identification of cell cycle-regulated genes of the yeast Saccharomyces cerevisiae by microarray hybridization

31 March 2020

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Progressive cis-inhibition of telomerase upon telomere elongation.

31 March 2020

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The number of vertebrate repeats can be regulated at yeast telomeres by Rap1-independent mechanisms

31 March 2020

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Origin activation and formation of single-strand TG1-3 tails occur sequentially in late S phase on a yeast linear plasmid

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRM1256

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Dimensions Publication ID

9 August 2017

1006364393

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