mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling (Q35581650)

9 August 2017

title

mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling (English)

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9 August 2017

author name string

Vanessa S Rodrik-Outmezguine

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9 August 2017

Sarat Chandarlapaty

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9 August 2017

Nen C Pagano

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9 August 2017

Poulikos I Poulikakos

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9 August 2017

Maurizio Scaltriti

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9 August 2017

Elizabeth Moskatel

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9 August 2017

José Baselga

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9 August 2017

Sylvie Guichard

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9 August 2017

Neal Rosen

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9 August 2017

publication date

17 June 2011

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9 August 2017

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9 August 2017

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9 August 2017

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9 August 2017

page(s)

248-259

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PI3K inhibition results in enhanced HER signaling and acquired ERK dependency in HER2-overexpressing breast cancer

9 August 2017

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Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2

27 July 2018

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mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

27 July 2018

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Identification of IRS-1 Ser-1101 as a target of S6K1 in nutrient- and obesity-induced insulin resistance

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27 July 2018

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27 July 2018

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27 July 2018

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27 July 2018

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

27 July 2018

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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton

27 July 2018

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

27 July 2018

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27 July 2018

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27 July 2018

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Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

27 July 2018

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27 July 2018

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Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP

27 July 2018

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27 July 2018

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26 September 2018

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New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs).

26 September 2018

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Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

26 September 2018

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Simultaneous inhibition of mTORC1 and mTORC2 by mTOR kinase inhibitor AZD8055 induces autophagy and cell death in cancer cells

26 September 2018

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Everolimus (RAD001) in the treatment of advanced renal cell carcinoma: a review

26 September 2018

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A negative feedback signaling network underlies oncogene-induced senescence

26 September 2018

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The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells

26 September 2018

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mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes

26 September 2018

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Distinct signaling events downstream of mTOR cooperate to mediate the effects of amino acids and insulin on initiation factor 4E-binding proteins

26 September 2018

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Upstream and downstream of mTOR

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227125

A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1.

26 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3227125

10.1158/2159-8290.CD-11-0085

26 September 2018

Identifiers

DOI

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9 August 2017

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9 August 2017

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