Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking (Q35569915)

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scientific article published on 2 March 2015

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English	Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking	scientific article published on 2 March 2015

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scholarly article

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Europe PubMed Central

PubMed publication ID

8 August 2017

Small molecule schweinfurthins selectively inhibit cancer cell proliferation and mTOR/AKT signaling by interfering with trans-Golgi-network trafficking (English)

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8 August 2017

David G.I. Kingston

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David G I Kingston

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8 August 2017

author name string

Xingfeng Bao

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Wanjun Zheng

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Naoko Hata Sugi

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Kishan L Agarwala

4

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8 August 2017

Qunli Xu

5

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8 August 2017

Zichun Wang

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Karen Tendyke

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8 August 2017

Winnie Lee

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Lana Parent

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Wei Li

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Hongsheng Cheng

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Yongchun Shen

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Noel Taylor

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Zoltan Dezso

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8 August 2017

Hong Du

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Yoshihiko Kotake

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Nanding Zhao

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John Wang

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Maarten Postema

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Mary Woodall-Jappe

20

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8 August 2017

Yasutaka Takase

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Toshimitsu Uenaka

22

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8 August 2017

Kenichi Nomoto

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8 August 2017

publication date

2 March 2015

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8 August 2017

Cancer Biology and Therapy

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8 August 2017

16

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589-601

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8 August 2017

Synthesis of indole analogues of the natural schweinfurthins

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12 July 2018

PTEN loss defines a PI3K/AKT pathway-dependent germinal center subtype of diffuse large B-cell lymphoma

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Rab GTPase regulation of membrane identity

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Functional evaluation of a fluorescent schweinfurthin: mechanism of cytotoxicity and intracellular quantification

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Membrane trafficking and signaling: two sides of the same coin

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High frequency of PIK3R1 and PIK3R2 mutations in endometrial cancer elucidates a novel mechanism for regulation of PTEN protein stability

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Natural products reveal cancer cell dependence on oxysterol-binding proteins

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Membrane-trafficking sorting hubs: cooperation between PI4P and small GTPases at the trans-Golgi network

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Pleiotropic effects of a schweinfurthin on isoprenoid homeostasis

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12 July 2018

Regulation of AKT phosphorylation at Ser473 and Thr308 by endoplasmic reticulum stress modulates substrate specificity in a severity dependent manner

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12 July 2018

Physiology and Pathology of Endosome‐to‐Golgi Retrograde Sorting

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12 July 2018

Hallmarks of Cancer: The Next Generation

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12 July 2018

A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking

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12 July 2018

Critical role of PI3K signaling for NF-kappaB-dependent survival in a subset of activated B-cell-like diffuse large B-cell lymphoma cells.

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12 July 2018

Use of Glycan Microarrays to Explore Specificity of Glycan-Binding Proteins

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12 July 2018

Fluorescent schweinfurthin B and F analogs with anti-proliferative activity

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Multivesicular body formation requires OSBP-related proteins and cholesterol

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12 July 2018

Schweinfurthin A selectively inhibits proliferation and Rho signaling in glioma and neurofibromatosis type 1 tumor cells in a NF1-GRD-dependent manner.

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Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma

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PtdIns4 P recognition by Vps74/GOLPH3 links PtdIns 4-kinase signaling to retrograde Golgi trafficking

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Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase

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The diverse functions of oxysterol-binding proteins

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GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

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NF2/merlin is a novel negative regulator of mTOR complex 1, and activation of mTORC1 is associated with meningioma and schwannoma growth

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Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities

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The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1

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Identifiers

10.1080/15384047.2015.1019184

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

8 August 2017

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