Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes (Q35559725)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25473037%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

title

Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes (English)

1 reference

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24 February 2020

1 reference

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24 February 2020

1 reference

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24 February 2020

David I Bernstein

1 reference

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24 February 2020

James M Hill

1 reference

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24 February 2020

Debra C Quenelle

1 reference

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24 February 2020

Rhonda D Cardin

1 reference

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24 February 2020

Jodi L Vogel

1 reference

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24 February 2020

Christian Clement

1 reference

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24 February 2020

Fernando J Bravo

1 reference

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24 February 2020

Timothy P Foster

1 reference

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24 February 2020

Marta Bosch-Marce

1 reference

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24 February 2020

Priya Raja

1 reference

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24 February 2020

David M Knipe

1 reference

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24 February 2020

Thomas M Kristie

1 reference

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24 February 2020

language of work or name

English

0 references

publication date

1 December 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25473037%20AND%20SRC:MED&resulttype=core&format=json

Science Translational Medicine

24 February 2020

published in

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24 February 2020

volume

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24 February 2020

issue

265

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24 February 2020

page(s)

265ra169

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Predicting the outcomes of treatment to eradicate the latent reservoir for HIV-1

24 February 2020

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27 July 2018

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27 July 2018

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Master transcription factors and mediator establish super-enhancers at key cell identity genes

27 July 2018

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Reactivation of latent HIV by histone deacetylase inhibitors.

27 July 2018

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An adjuvanted herpes simplex virus 2 subunit vaccine elicits a T cell response in mice and is an effective therapeutic vaccine in Guinea pigs

27 July 2018

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Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection

27 July 2018

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Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency

27 July 2018

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Topical SMIP-7.7, a toll-like receptor 7 agonist, protects against genital herpes simplex virus type-2 disease in the guinea pig model of genital herpes

27 July 2018

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Snapshots: chromatin control of viral infection

27 July 2018

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27 July 2018

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A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells

27 July 2018

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27 July 2018

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Herpes simplex virus 1 DNA is in unstable nucleosomes throughout the lytic infection cycle, and the instability of the nucleosomes is independent of DNA replication

27 July 2018

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Herpes simplex epithelial and stromal keratitis: an epidemiologic update

27 July 2018

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CMX001 Potentiates the Efficacy of Acyclovir in Herpes Simplex Virus Infections

27 July 2018

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Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.

27 July 2018

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Suppression of inflammation by a synthetic histone mimic

27 July 2018

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27 July 2018

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27 July 2018

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Epigenetic opportunities and challenges in cancer

27 July 2018

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Epigenetic mechanisms in neurological diseases: genes, syndromes, and therapies

27 July 2018

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Control of alpha-herpesvirus IE gene expression by HCF-1 coupled chromatin modification activities

27 July 2018

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Persistence of HIV-1 receptor-positive cells after HSV-2 reactivation is a potential mechanism for increased HIV-1 acquisition

27 July 2018

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Transcription of the herpes simplex virus latency-associated transcript promotes the formation of facultative heterochromatin on lytic promoters

27 July 2018

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Engagement of the lysine-specific demethylase/HDAC1/CoREST/REST complex by herpes simplex virus 1.

27 July 2018

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Effect of aciclovir on HIV-1 acquisition in herpes simplex virus 2 seropositive women and men who have sex with men: a randomised, double-blind, placebo-controlled trial

27 July 2018

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The high prevalence of herpes simplex virus type 1 DNA in human trigeminal ganglia is not a function of age or gender

27 July 2018

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Role for A-type lamins in herpesviral DNA targeting and heterochromatin modulation

27 July 2018

1 reference

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Chromatin control of herpes simplex virus lytic and latent infection

27 July 2018

1 reference

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The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4 trimethylation at herpesvirus immediate early promoters for initiation of infection

27 July 2018

1 reference

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trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.

27 July 2018

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Herpes simplex virus 2 infection increases HIV acquisition in men and women: systematic review and meta-analysis of longitudinal studies.

27 July 2018

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Chronic herpes simplex virus type-2 infection and HIV viral load

27 July 2018

1 reference

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Herpesviral latency-associated transcript gene promotes assembly of heterochromatin on viral lytic-gene promoters in latent infection

27 July 2018

1 reference

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Risk of human immunodeficiency virus infection in herpes simplex virus type 2-seropositive persons: a meta-analysis

27 July 2018

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Vaccination with recombinant herpes simplex virus glycoproteins: protection against initial and recurrent genital herpes

27 July 2018

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A histone deacetylase inhibitor improves hypothyroidism caused by a TRα1 mutant

27 July 2018

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Acyclovir prophylaxis predisposes to antiviral-resistant recurrent herpetic keratitis.

26 September 2018

1 reference

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A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency

26 September 2018

1 reference

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Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia

26 September 2018

1 reference

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Curing HIV: Pharmacologic approaches to target HIV-1 latency

26 September 2018

1 reference

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Changes to euchromatin on LAT and ICP4 following reactivation are more prevalent in an efficiently reactivating strain of HSV-1.

26 September 2018

1 reference

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Establishment of HIV latency in primary CD4+ cells is due to epigenetic transcriptional silencing and P-TEFb restriction

26 September 2018

1 reference

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Epigenetic regulation of latent HSV-1 gene expression

26 September 2018

1 reference

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Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency

26 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4416407

The polycomb group protein Bmi1 binds to the herpes simplex virus 1 latent genome and maintains repressive histone marks during latency

26 September 2018

1 reference

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Effect of herpes simplex suppression on incidence of HIV among women in Tanzania

26 September 2018

1 reference

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In vivo changes in the patterns of chromatin structure associated with the latent herpes simplex virus type 1 genome in mouse trigeminal ganglia can be detected at early times after butyrate treatment

26 September 2018

1 reference

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Tranylcypromine reduces herpes simplex virus 1 infection in mice

26 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1126%2FSCITRANSLMED.3010643

21 January 2018

Herpes simplex keratitis

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/25473037

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1126/SCITRANSLMED.3010643

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25473037%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25473037%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

PubMed publication ID

25473037

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25473037%20AND%20SRC:MED&resulttype=core&format=json