Hippo signaling pathway in liver and pancreas: the potential drug target for tumor therapy (Q35484837)

8 August 2017

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title

Hippo signaling pathway in liver and pancreas: the potential drug target for tumor therapy (English)

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8 August 2017

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Delin Kong

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8 August 2017

Yicheng Zhao

series ordinal

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8 August 2017

Tong Men

series ordinal

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8 August 2017

Chun-Bo Teng

series ordinal

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8 August 2017

publication date

3 December 2014

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Journal of Drug Targeting

8 August 2017

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inferred from page(s)

published in

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8 August 2017

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8 August 2017

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8 August 2017

page(s)

125-133

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Generation and regeneration of cells of the liver and pancreas

8 August 2017

cites work

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila Homolog of YAP

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Elucidation of a universal size-control mechanism in Drosophila and mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

YAP/TAZ as mechanosensors and mechanotransducers in regulating organ size and tumor growth

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Mutations in genes encoding the cadherin receptor-ligand pair DCHS1 and FAT4 disrupt cerebral cortical development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

An evolutionary shift in the regulation of the Hippo pathway between mice and flies

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Mst1 and Mst2 maintain hepatocyte quiescence and suppress hepatocellular carcinoma development through inactivation of the Yap1 oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

TAZ: a novel transcriptional co-activator regulated by interactions with 14-3-3 and PDZ domain proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Mask is required for the activity of the Hippo pathway effector Yki/YAP.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Mask proteins are cofactors of Yorkie/YAP in the Hippo pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The Hippo-YAP pathway: new connections between regulation of organ size and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Cell polarity in eggs and epithelia: parallels and diversity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The roles of the cadherins Fat and Dachsous in planar polarity specification in Drosophila

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Integration of intercellular signaling through the Hippo pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Interactions between the crumbs, lethal giant larvae and bazooka pathways in epithelial polarization.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

A genetic hierarchy controlling cell polarity.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Integrated activity of PDZ protein complexes regulates epithelial polarity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Angiomotin family proteins are novel activators of the LATS2 kinase tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

KIBRA suppresses apical exocytosis through inhibition of aPKC kinase activity in epithelial cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

KIBRA is a novel substrate for protein kinase Czeta

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Yap1 acts downstream of α-catenin to control epidermal proliferation

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

A Tight Junction-Associated Merlin-Angiomotin Complex Mediates Merlin's Regulation of Mitogenic Signaling and Tumor Suppressive Functions

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The p130 isoform of angiomotin is required for Yap-mediated hepatic epithelial cell proliferation and tumorigenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Functional complexes between YAP2 and ZO-2 are PDZ domain-dependent, and regulate YAP2 nuclear localization and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Cell detachment activates the Hippo pathway via cytoskeleton reorganization to induce anoikis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Cytoskeletal control of growth and cell fate switching

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Hippo pathway regulation by cell morphology and stress fibers.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

A mechanical checkpoint controls multicellular growth through YAP/TAZ regulation by actin-processing factors.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Angiomotins link F-actin architecture to Hippo pathway signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Tao kinases as coordinators of actin and microtubule dynamics in developing neurons

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Cloning of common carp SOCS-3 gene and its expression during embryogenesis, GH-transgene and viral infection

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The sterile 20-like kinase Tao-1 controls tissue growth by regulating the Salvador-Warts-Hippo pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Tao-1 phosphorylates Hippo/MST kinases to regulate the Hippo-Salvador-Warts tumor suppressor pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Cytoskeletal tension inhibits Hippo signaling through an Ajuba-Warts complex

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Role of YAP/TAZ in mechanotransduction

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Regulation of Hippo signaling by EGFR-MAPK signaling through Ajuba family proteins.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Regulation of Hippo pathway by mitogenic growth factors via phosphoinositide 3-kinase and phosphoinositide-dependent kinase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

G protein-coupled receptors engage the mammalian Hippo pathway through F-actin: F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Wnt/beta-catenin signaling: components, mechanisms, and diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

YAP/TAZ incorporation in the β-catenin destruction complex orchestrates the Wnt response

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The two faces of Hippo: targeting the Hippo pathway for regenerative medicine and cancer treatment

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The Hippo pathway and human cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The Hippo pathway in disease and therapy: cancer and beyond

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

YAP1 increases organ size and expands undifferentiated progenitor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Mst1/2 signalling to Yap: gatekeeper for liver size and tumour development

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

A cell-based assay to screen stimulators of the Hippo pathway reveals the inhibitory effect of dobutamine on the YAP-dependent gene transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The hippo-yes association protein pathway in liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Nf2/Merlin controls progenitor homeostasis and tumorigenesis in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The Hippo-Salvador pathway restrains hepatic oval cell proliferation, liver size, and liver tumorigenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Liver stem cells: implications for hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Hippo pathway activity influences liver cell fate

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Mutual interaction between YAP and c-Myc is critical for carcinogenesis in liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Mutual interaction between YAP and CREB promotes tumorigenesis in liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Mutual inhibition between YAP and SRSF1 maintains long non-coding RNA, Malat1-induced tumourigenesis in liver cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Yes-associated protein up-regulates Jagged-1 and activates the Notch pathway in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Activation of β-catenin and Yap1 in human hepatoblastoma and induction of hepatocarcinogenesis in mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Developmental biology of the pancreas: a comprehensive review

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Hippo signaling regulates pancreas development through inactivation of Yap.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Hippo signaling regulates differentiation and maintenance in the exocrine pancreas

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

miR-375 inhibits proliferation of mouse pancreatic progenitor cells by targeting YAP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Down-regulation of Yes Associated Protein 1 expression reduces cell proliferation and clonogenicity of pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

The PDZ-binding motif of Yes-associated protein is required for its co-activation of TEAD-mediated CTGF transcription and oncogenic cell transforming activity

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

A peptide mimicking VGLL4 function acts as a YAP antagonist therapy against gastric cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Identification, mechanism of action, and antitumor activity of a small molecule inhibitor of hippo, TGF-β, and Wnt signaling pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

Identification of Serum-Derived Sphingosine-1-Phosphate as a Small Molecule Regulator of YAP

21 January 2018

1 reference

https://api.crossref.org/works/10.3109%2F1061186X.2014.983522

10.3109/1061186X.2014.983522

21 January 2018

Identifiers

DOI

1 reference

release_4kxsno6bizbafg4bwsrqky2n7y

8 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/4kxsno6bizbafg4bwsrqky2n7y

mapped directly with Wikidata item

24 November 2022

based on heuristic

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