Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia (Q35186888)

7 August 2017

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title

Therapeutic efficacy of prenylation inhibitors in the treatment of myeloid leukemia (English)

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7 August 2017

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Morgan MA

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7 August 2017

Ganser A

series ordinal

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7 August 2017

Reuter CW

series ordinal

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7 August 2017

publication date

1 August 2003

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7 August 2017

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7 August 2017

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7 August 2017

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7 August 2017

page(s)

1482-1498

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The Ras branch of small GTPases: Ras family members don't fall far from the tree

7 August 2017

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Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis

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Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in haematopoietic cells

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Alterations of the FLT3 gene in acute promyelocytic leukemia: association with diagnostic characteristics and analysis of clinical outcome in patients treated with the Italian AIDA protocol

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The molecular genetics of Philadelphia chromosome-positive leukemias

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The biology of chronic myeloid leukemia

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Nf1 and Gmcsf interact in myeloid leukemogenesis

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BAY 43-9006: early clinical data in patients with advanced solid malignancies

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Farnesyltransferase and geranylgeranyltransferase I inhibitors and cancer therapy: lessons from mechanism and bench-to-bedside translational studies

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21 January 2018

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21 January 2018

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21 January 2018

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Rho GTPases in cell biology

21 January 2018

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Rho GTPases and their effector proteins

21 January 2018

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Rho family proteins: coordinating cell responses

21 January 2018

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RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors

21 January 2018

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Cell growth inhibition by farnesyltransferase inhibitors is mediated by gain of geranylgeranylated RhoB.

21 January 2018

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Direct demonstration of geranylgeranylation and farnesylation of Ki-Ras in vivo

21 January 2018

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

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Combination of the novel farnesyltransferase inhibitor RPR130401 and the geranylgeranyltransferase-1 inhibitor GGTI-298 disrupts MAP kinase activation and G(1)-S transition in Ki-Ras-overexpressing transformed adrenocortical cells

21 January 2018

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Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells.

21 January 2018

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Anions modulate the potency of geranylgeranyl-protein transferase I inhibitors

21 January 2018

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Disruption of Oncogenic K-Ras4B Processing and Signaling by a Potent Geranylgeranyltransferase I Inhibitor

21 January 2018

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Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines

21 January 2018

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21 January 2018

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Potent, highly selective, and non-thiol inhibitors of protein geranylgeranyltransferase-I.

21 January 2018

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21 January 2018

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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

21 January 2018

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The Geranylgeranyltransferase-I Inhibitor GGTI-298 Arrests Human Tumor Cells in G0/G1 and Induces p21WAF1/CIP1/SDI1 in a p53-independent Manner

21 January 2018

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p21(WAF1/CIP1) is upregulated by the geranylgeranyltransferase I inhibitor GGTI-298 through a transforming growth factor beta- and Sp1-responsive element: involvement of the small GTPase rhoA.

21 January 2018

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Novel lipid-regulating drugs

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HMG-CoA reductase inhibitors and the malignant cell: the statin family of drugs as triggers of tumor-specific apoptosis

21 January 2018

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21 January 2018

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Lovastatin induces a pronounced differentiation response in acute myeloid leukemias

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A comparison of the effect of the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors simvastatin, lovastatin and pravastatin on leukaemic and normal bone marrow progenitors

21 January 2018

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Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells

21 January 2018

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Effect of simvastatin alone and in combination with cytosine arabinoside on the proliferation of myeloid leukemia cell lines

21 January 2018

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Mevastatin can increase toxicity in primary AMLs exposed to standard therapeutic agents, but statin efficacy is not simply associated with ras hotspot mutations or overexpression

21 January 2018

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Inhibitory effect of simvastatin on the proliferation of human myeloid leukaemia cells in severe combined immunodeficient (SCID) mice

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Lovastatin induced control of blast cell growth in an elderly patient with acute myeloblastic leukemia

21 January 2018

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Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses

21 January 2018

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Farnesyl transferase inhibitors as anticancer agents

21 January 2018

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Clinical and biologic activity of the farnesyltransferase inhibitor R115777 in adults with refractory and relapsed acute leukemias: a phase 1 clinical-laboratory correlative trial

21 January 2018

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Phase I and pharmacokinetic study of the orally administered farnesyl transferase inhibitor R115777 in patients with advanced solid tumors

21 January 2018

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Phase I clinical and pharmacologic study of chronic oral administration of the farnesyl protein transferase inhibitor R115777 in advanced cancer

21 January 2018

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Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies

21 January 2018

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Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

21 January 2018

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21 January 2018

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Activity of the farnesyl protein transferase inhibitor SCH66336 against BCR/ABL-induced murine leukemia and primary cells from patients with chronic myeloid leukemia

21 January 2018

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Treatment of Bcr/Abl-positive acute lymphoblastic leukemia in P190 transgenic mice with the farnesyl transferase inhibitor SCH66336.

21 January 2018

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21 January 2018

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Apoptotic synergism between STI571 and the farnesyl transferase inhibitor SCH66336 on an imatinib-sensitive cell line

21 January 2018

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Phase I and pharmacokinetic study of the oral farnesyl transferase inhibitor SCH 66336 given twice daily to patients with advanced solid tumors

21 January 2018

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Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity

21 January 2018

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Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

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Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity

21 January 2018

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A mutant form of human protein farnesyltransferase exhibits increased resistance to farnesyltransferase inhibitors

21 January 2018

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RAS gene mutations in acute and chronic myelocytic leukemias, chronic myeloproliferative disorders, and myelodysplastic syndromes

21 January 2018

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Mutations in ras proto-oncogenes are associated with lower mdr1 gene expression in adult acute myeloid leukaemia

21 January 2018

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Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes

21 January 2018

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Analysis of RAS oncogene mutations in human lymphoid malignancies

21 January 2018

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Ras oncogene mutation in multiple myeloma

21 January 2018

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Detection of N-Ras codon 61 mutations in subpopulations of tumor cells in multiple myeloma at presentation

21 January 2018

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RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: a 10-year follow-up.

21 January 2018

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FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia.

21 January 2018

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Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies

21 January 2018

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Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia

21 January 2018

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21 January 2018

Role of FLT3 in leukemia

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Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis

21 January 2018

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Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associated hematologic disorder

21 January 2018

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Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: a possible explanation for divergent clinical behavior

21 January 2018

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Signal transduction and transforming properties of the TEL-TRKC fusions associated with t(12;15)(p13;q25) in congenital fibrosarcoma and acute myelogenous leukemia

21 January 2018

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The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

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Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders

21 January 2018

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Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A

21 January 2018

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Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

21 January 2018

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21 January 2018

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High incidence of N and K-Ras activating mutations in multiple myeloma and primary plasma cell leukemia at diagnosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

Farnesyltransferase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Effects of deregulated Raf activation on integrin, cytokine-receptor expression and the induction of apoptosis in hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

c-kit point mutation of extracellular domain in patients with myeloproliferative disorders

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Internal tandem duplication of the FLT3 gene is a novel modality of elongation mutation which causes constitutive activation of the product

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Biological characteristics and prognosis of adult acute myeloid leukemia with internal tandem duplications in the Flt3 gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia. The Children's Cancer and Leukemia Study Group, Japan

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Tandem duplication of the FLT3 gene is infrequent in infant acute leukemia. Japan Infant Leukemia Study Group

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Characteristics and outcome of t(8;21)-positive childhood acute myeloid leukemia: a single institution's experience

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Farnesyltransferase inhibitors: antineoplastic mechanism and clinical prospects

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Both farnesylated and geranylgeranylated RhoB inhibit malignant transformation and suppress human tumor growth in nude mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Induction of apoptosis by lovastatin through activation of caspase-3 and DNase II in leukaemia HL-60 cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

The farnesyl protein transferase inhibitor SCH66336 synergizes with taxanes in vitro and enhances their antitumor activity in vivo

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Characterization of Ha-ras, N-ras, Ki-Ras4A, and Ki-Ras4B as in vitro substrates for farnesyl protein transferase and geranylgeranyl protein transferase type I

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

RAS gene mutations in childhood acute myeloid leukemia: a Pediatric Oncology Group study

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Detection of NPM-ALK DNA rearrangement in CD30 positive anaplastic large cell lymphoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2403024

7 January 2021

Identifiers

DOI

10.1038/SJ.LEU.2403024

1 reference

7 August 2017

1 reference