Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells. (Q36622317)

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scientific article published on June 2001

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English	Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells.	scientific article published on June 2001

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8 November 2019

Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells (English)

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8 November 2019

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Antonello Di Paolo

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8 November 2019

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8 November 2019

Mario Del Tacca

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M Del Tacca

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8 November 2019

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S Caputo

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8 November 2019

M Macchia

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8 November 2019

M Lastella

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8 November 2019

U Boggi

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8 November 2019

F Mosca

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8 November 2019

A Marchetti

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8 November 2019

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1 June 2001

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8 November 2019

British Journal of Cancer

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8 November 2019

84

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8 November 2019

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8 November 2019

1535-1543

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8 November 2019

Regulation of the cytoskeleton and cell adhesion by the Rho family GTPases in mammalian cells.

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The role of Rho in G protein-coupled receptor signal transduction

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Selective inhibition of cyclooxygenase-2 enhances mitomycin-C-induced apoptosis

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Recent advances in the study of prenylated proteins

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Enzymology and biology of CaaX protein prenylation.

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Non-Ras targets of farnesyltransferase inhibitors: focus on Rho.

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Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

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Identification of Ras farnesyltransferase inhibitors by microbial screening

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30 September 2017

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1

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30 September 2017

Paclitaxel (taxol) inhibits protein isoprenylation and induces apoptosis in PC-3 human prostate cancer cells

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30 September 2017

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Critical role of Rho in cell transformation by oncogenic Ras.

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30 September 2017

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine

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28 June 2018

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

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28 June 2018

Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

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28 June 2018

Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

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28 June 2018

Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

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Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer

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K-ras mutation: early detection in molecular diagnosis and risk assessment of colorectal, pancreas, and lung cancers--a review

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12 December 2020

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Geranylgeranylated rho small GTPase(s) are essential for the degradation of p27Kip1 and facilitate the progression from G1 to S phase in growth-stimulated rat FRTL-5 cells

1 reference

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GGTI-298 induces G0-G1 block and apoptosis whereas FTI-277 causes G2-M enrichment in A549 cells

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12 December 2020

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Inhibition of Growth and Invasive Activity of Human Pancreatic Cancer Cells by a Farnesyltransferase Inhibitor, Manumycin

1 reference

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12 December 2020

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Geranylgeranyl diphosphate-based inhibitors of post-translational geranylgeranylation of cellular proteins

1 reference

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1 reference

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Identifiers

10.1054/BJOC.2001.1820

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Europe PubMed Central

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8 November 2019

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8 November 2019

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8 November 2019

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