CDK inhibitors in clinical development for the treatment of cancer (Q35143997)

6 August 2017

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title

CDK inhibitors in clinical development for the treatment of cancer (English)

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ORCID Public Data File 2021

6 August 2017

Peter M Fischer

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author name string

Athos Gianella-Borradori

series ordinal

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6 August 2017

language of work or name

English

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publication date

1 June 2003

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Expert Opinion on Investigational Drugs

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

955-970

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Pharmacological inhibitors of cyclin-dependent kinases

6 August 2017

cites work

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https://api.crossref.org/works/10.1517%2F13543784.12.6.955

To cycle or not to cycle: a critical decision in cancer.

21 January 2018

1 reference

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Designing inhibitors of cyclin-dependent kinases

21 January 2018

1 reference

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Progress toward the development of agents to modulate the cell cycle

21 January 2018

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A new alkaloid AM-2282 OF Streptomyces origin. Taxonomy, fermentation, isolation and preliminary characterization

21 January 2018

1 reference

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UCN-01, 7-hydroxyl-staurosporine, inhibits kinase activity of cyclin-dependent kinases and reduces the phosphorylation of the retinoblastoma susceptibility gene product in A549 human lung cancer cell line

21 January 2018

1 reference

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The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01

21 January 2018

1 reference

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Discovery of aminothiazole inhibitors of cyclin-dependent kinase 2: synthesis, X-ray crystallographic analysis, and biological activities

21 January 2018

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Mechanisms of action of flavopiridol

21 January 2018

1 reference

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Development of cyclin-dependent kinase modulators as novel therapeutic approaches for hematological malignancies

21 January 2018

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Flavopiridol, a novel cyclin-dependent kinase inhibitor, in clinical development

21 January 2018

1 reference

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The cell cycle as a target for cancer therapy: basic and clinical findings with the small molecule inhibitors flavopiridol and UCN-01.

21 January 2018

1 reference

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E7070: a novel synthetic sulfonamide targeting the cell cycle progression for the treatment of cancer

21 January 2018

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Indisulam: an anticancer sulfonamide in clinical development

21 January 2018

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Distinct roles for cyclin-dependent kinases in cell cycle control

21 January 2018

1 reference

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The cyclin-dependent kinase inhibitors olomoucine and roscovitine arrest human fibroblasts in G1 phase by specific inhibition of CDK2 kinase activity

21 January 2018

1 reference

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Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo

21 January 2018

1 reference

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Relationship of CDK-activating kinase and RNA polymerase II CTD kinase TFIIH/TFIIK

21 January 2018

1 reference

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Cyclin C/CDK8 and cyclin H/CDK7/p36 are biochemically distinct CTD kinases

21 January 2018

1 reference

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UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.

21 January 2018

1 reference

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Re-expression of p16INK4a in mesothelioma cells results in cell cycle arrest, cell death, tumor suppression and tumor regression

21 January 2018

1 reference

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Differential effects of staurosporine analogues on cell cycle, growth and viability in A549 cells

21 January 2018

1 reference

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Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

21 January 2018

1 reference

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Preclinical and clinical development of cyclin-dependent kinase modulators

21 January 2018

1 reference

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Using cancer genetics to guide the selection of anticancer drug targets

21 January 2018

1 reference

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Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

Selective killing of transformed cells by cyclin/cyclin-dependent kinase 2 antagonists

21 January 2018

1 reference

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Potent inhibitors of cyclin-dependent kinase 2 induce nuclear accumulation of wild-type p53 and nucleolar fragmentation in human untransformed and tumor-derived cells

21 January 2018

1 reference

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Cyclin a-CDK phosphorylation regulates MDM2 protein interactions

21 January 2018

1 reference

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Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2

21 January 2018

1 reference

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Increased and altered DNA binding of human p53 by S and G2/M but not Gl cyclin-dependent kinases

21 January 2018

1 reference

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The complexity of p53 modulation: emerging patterns from divergent signals

21 January 2018

1 reference

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Potent induction of wild-type p53-dependent transcription in tumour cells by a synthetic inhibitor of cyclin-dependent kinases

21 January 2018

1 reference

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Farnesyl transferase inhibitors: a novel targeted tnerapy for cancer

21 January 2018

1 reference

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Cdk inhibitors, roscovitine and olomoucine, synergize with farnesyltransferase inhibitor (FTI) to induce efficient apoptosis of human cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

The retinoblastoma tumor suppressor inhibits cellular proliferation through two distinct mechanisms: inhibition of cell cycle progression and induction of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

Current status of clinical trials of farnesyltransferase inhibitors.

21 January 2018

1 reference

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Modulation by (iso)flavonoids of the ATPase activity of the multidrug resistance protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

Potent interaction of flavopiridol with MRP1

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

Phase II study of the cyclin-dependent kinase inhibitor flavopiridol administered to patients with advanced gastric carcinoma.

21 January 2018

1 reference

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Identification of cytosolic aldehyde dehydrogenase 1 from non-small cell lung carcinomas as a flavopiridol-binding protein

21 January 2018

1 reference

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Phase I clinical and pharmacokinetic study of flavopiridol administered as a daily 1-hour infusion in patients with advanced neoplasms

21 January 2018

1 reference

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Protein kinases--the major drug targets of the twenty-first century?

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

Mechanisms of action of the novel sulfonamide anticancer agent E7070 on cell cycle progression in human non-small cell lung cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

If not apoptosis, then what? Treatment-induced senescence and mitotic catastrophe in tumor cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

Human cyclin A is required for mitosis until mid prophase

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with Roscovitine, a novel cyclin-dependent kinase antagonist

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

Cyclin-dependent kinases as cellular targets for antiviral drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

Role for cyclin A in the dependence of mitosis on completion of DMA replication

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.12.6.955

10.1517/13543784.12.6.955

21 January 2018

Identifiers

DOI

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release_igfuf3bb5nhrjhkdifsaq23hpu

6 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/igfuf3bb5nhrjhkdifsaq23hpu

mapped directly with Wikidata item

24 November 2022

based on heuristic

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