Pleiotropic actions of sphingosine-1-phosphate (Q35146936)

6 August 2017

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title

Pleiotropic actions of sphingosine-1-phosphate (English)

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6 August 2017

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Sarah Spiegel

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6 August 2017

Sheldon Milstien

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6 August 2017

Kenneth Watterson

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6 August 2017

Heidi Sankala

series ordinal

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6 August 2017

publication date

1 July 2003

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Progress in Lipid Research

6 August 2017

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inferred from page(s)

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

344-357

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Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

6 August 2017

cites work

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https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate

1 reference

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7 January 2021

Sphingosine-1-phosphate as a ligand for the G protein-coupled receptor EDG-1

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Functions of a new family of sphingosine-1-phosphate receptors

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https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine-1-phosphate modulates growth and adhesion of ovarian cancer cells

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https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate signalling in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine-1-phosphate: signaling inside and out.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Conversion of dihydroceramide to ceramide occurs at the cytosolic face of the endoplasmic reticulum

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Functions of ceramide in coordinating cellular responses to stress

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Regulation of ceramide production and apoptosis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate: a prototype of a new class of second messengers.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Antiproliferative properties of sphingosine 1-phosphate in human hepatic myofibroblasts. A cyclooxygenase-2 mediated pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Apoptotic effect of sphingosine 1-phosphate and increased sphingosine 1-phosphate hydrolysis on mesangial cells cultured at low cell density

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Oocyte apoptosis is suppressed by disruption of the acid sphingomyelinase gene or by sphingosine-1-phosphate therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate preserves fertility in irradiated female mice without propagating genomic damage in offspring

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Molecular cloning and functional characterization of a novel mammalian sphingosine kinase type 2 isoform

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Functional characterization of human sphingosine kinase-1

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https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors

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https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine kinase expression increases intracellular sphingosine-1-phosphate and promotes cell growth and survival.

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https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

An oncogenic role of sphingosine kinase

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https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Expression of a catalytically inactive sphingosine kinase mutant blocks agonist-induced sphingosine kinase activation. A dominant-negative sphingosine kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Characterization of murine sphingosine-1-phosphate phosphohydrolase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine-1-phosphate and lipid phosphohydrolases

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Rho-mediated phosphorylation of focal adhesion kinase and myosin light chain in human endothelial cells stimulated with sphingosine 1-phosphate, a bioactive lysophospholipid released from activated platelets

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate modulates human airway smooth muscle cell functions that promote inflammation and airway remodeling in asthma

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Neutral/alkaline and acid ceramidase activities are actively released by murine endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Secretory sphingomyelinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Extracellular export of sphingosine kinase-1 enzyme. Sphingosine 1-phosphate generation and the induction of angiogenic vascular maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Lipid phosphate phosphatases regulate signal transduction through glycerolipids and sphingolipids

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Lysophospholipids--receptor revelations

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https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Lysophosphatidic acid receptors

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https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Lysophospholipid receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Complete cDNA sequence, genomic structure, and chromosomal localization of the LPA receptor gene, lpA1/vzg-1/Gpcr26.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

1 reference

7 January 2021

Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate.

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https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Lysophosphatidic acid stimulates the G-protein-coupled receptor EDG-1 as a low affinity agonist

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Dual regulation of EDG1/S1P(1) receptor phosphorylation and internalization by protein kinase C and G-protein-coupled receptor kinase 2.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibitio

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate signalling through the G-protein-coupled receptor Edg-1.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Akt-mediated phosphorylation of the G protein-coupled receptor EDG-1 is required for endothelial cell chemotaxis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate activates Akt, nitric oxide production, and chemotaxis through a Gi protein/phosphoinositide 3-kinase pathway in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Subtype-specific, differential activities of the EDG family receptors for sphingosine-1-phosphate, a novel lysophospholipid mediator

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Vascular endothelial cell adherens junction assembly and morphogenesis induced by sphingosine-1-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

An essential role for the H218/AGR16/Edg-5/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)/EDG-3

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Signaling mechanisms and molecular characteristics of G protein-coupled receptors for lysophosphatidic acid and sphingosine 1-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Differential pharmacological properties and signal transduction of the sphingosine 1-phosphate receptors EDG-1, EDG-3, and EDG-5

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

The novel sphingosine 1-phosphate receptor AGR16 is coupled via pertussis toxin-sensitive and -insensitive G-proteins to multiple signalling pathways.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Comparison of intrinsic activities of the putative sphingosine 1-phosphate receptor subtypes to regulate several signaling pathways in their cDNA-transfected Chinese hamster ovary cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

EDG3 is a functional receptor specific for sphingosine 1-phosphate and sphingosylphosphorylcholine with signaling characteristics distinct from EDG1 and AGR16

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

G alpha 12 and G alpha 13 stimulate Rho-dependent stress fiber formation and focal adhesion assembly

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Characterization of a novel sphingosine 1-phosphate receptor, Edg-8

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Nrg-1 belongs to the endothelial differentiation gene family of G protein-coupled sphingosine-1-phosphate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate stimulates proliferation and migration of human endothelial cells possibly through the lipid receptors, Edg-1 and Edg-3

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate protects human umbilical vein endothelial cells from serum-deprived apoptosis by nitric oxide production

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Angiogenesis and G-protein-coupled receptors: signals that bridge the gap.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate stimulates cell migration through a G(i)-coupled cell surface receptor. Potential involvement in angiogenesis

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate stimulates tyrosine phosphorylation of focal adhesion kinase and chemotactic motility of endothelial cells via the G(i) protein-linked phospholipase C pathway

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

EDG-1 links the PDGF receptor to Src and focal adhesion kinase activation leading to lamellipodia formation and cell migration

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis.

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Homodimerization and heterodimerization of S1P/EDG sphingosine-1-phosphate receptors

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

Tethering of the platelet-derived growth factor beta receptor to G-protein-coupled receptors. A novel platform for integrative signaling by these receptor classes in mammalian cells

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

MAP kinases and hypoxia in the control of VEGF expression

1 reference

https://api.crossref.org/works/10.1016%2FS0163-7827%2803%2900015-8

7 January 2021

10.1016/S0163-7827(03)00015-8

Identifiers

DOI

1 reference

release_6hipj6qhbrcoraj2n42hyszg6m

6 August 2017

Fatcat ID

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Fatcat

https://api.fatcat.wiki/v0/release/6hipj6qhbrcoraj2n42hyszg6m

24 November 2022

mapped directly with Wikidata item

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