In vitro and pharmacophore insights into CYP3A enzymes (Q35111625)

6 August 2017

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title

In vitro and pharmacophore insights into CYP3A enzymes (English)

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6 August 2017

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6 August 2017

David M Stresser

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6 August 2017

J Andrew Williams

series ordinal

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6 August 2017

language of work or name

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1 April 2003

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Trends in Pharmacological Sciences

6 August 2017

published in

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6 August 2017

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6 August 2017

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6 August 2017

page(s)

161-166

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The human CYP3A subfamily: practical considerations

6 August 2017

cites work

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7 January 2021

Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression

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7 January 2021

cDNA cloning and initial characterization of CYP3A43, a novel human cytochrome P450

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7 January 2021

Design and application of fluorometric assays for human cytochrome P450 inhibition

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7 January 2021

Present and future in vitro approaches for drug metabolism.

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7 January 2021

Atypical kinetic profiles in drug metabolism reactions

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7 January 2021

Evaluation of atypical cytochrome P450 kinetics with two-substrate models: evidence that multiple substrates can simultaneously bind to cytochrome P450 active sites

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7 January 2021

CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

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7 January 2021

Phenylalanine and tryptophan scanning mutagenesis of CYP3A4 substrate recognition site residues and effect on substrate oxidation and cooperativity

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7 January 2021

Elucidation of distinct ligand binding sites for cytochrome P450 3A4

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7 January 2021

Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site

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7 January 2021

A kinetic model for the metabolic interaction of two substrates at the active site of cytochrome P450 3A4.

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7 January 2021

Covalent alteration of the CYP3A4 active site: evidence for multiple substrate binding domains

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7 January 2021

Analysis of four residues within substrate recognition site 4 of human cytochrome P450 3A4: role in steroid hydroxylase activity and alpha-naphthoflavone stimulation.

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7 January 2021

Drug-drug interactions: effect of quinidine on nifedipine binding to human cytochrome P450 3A4

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7 January 2021

Allosteric behavior in cytochrome p450-dependent in vitro drug-drug interactions: a prospective based on conformational dynamics

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7 January 2021

Towards a new age of virtual ADME/TOX and multidimensional drug discovery

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7 January 2021

In silico ADME/Tox: the state of the art.

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7 January 2021

Progress in predicting human ADME parameters in silico

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7 January 2021

Development of a generalized, quantitative physicochemical model of CYP3A4 inhibition for use in early drug discovery

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7 January 2021

Pharmacophore modeling of cytochromes P450.

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7 January 2021

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

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7 January 2021

Influence of P450 3A4 SRS-2 residues on cooperativity and/or regioselectivity of aflatoxin B(1) oxidation.

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7 January 2021

Identification of Three Key Residues in Substrate Recognition Site 5 of Human Cytochrome P450 3A4 by Cassette and Site-Directed Mutagenesis

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7 January 2021

Alanine-scanning mutagenesis of a putative substrate recognition site in human cytochrome P450 3A4. Role of residues 210 and 211 in flavonoid activation and substrate specificity

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7 January 2021

Molecular modeling of cytochrome P450 3A4

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7 January 2021

Evidence of impaired cisapride metabolism in neonates

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7 January 2021

Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

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7 January 2021

10.1016/S0165-6147(03)00049-X

Identifiers

DOI

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6 August 2017

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