The human CYP3A subfamily: practical considerations (Q34119161)

31 July 2017

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title

The human CYP3A subfamily: practical considerations (English)

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31 July 2017

Wrighton SA

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31 July 2017

Schuetz EG

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31 July 2017

Thummel KE

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31 July 2017

Shen DD

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31 July 2017

Korzekwa KR

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31 July 2017

Watkins PB

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31 July 2017

language of work or name

English

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publication date

1 August 2000

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31 July 2017

published in

Drug Metabolism Reviews

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31 July 2017

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31 July 2017

issue

3-4

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31 July 2017

page(s)

339-361

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The human hepatic cytochromes P450 involved in drug metabolism

31 July 2017

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A novel cis-acting element in a liver cytochrome P450 3A gene confers synergistic induction by glucocorticoids plus antiglucocorticoids

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Dexamethasone responsiveness of a major glucocorticoid-inducible CYP3A gene is mediated by elements unrelated to a glucocorticoid receptor binding motif

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The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor

21 January 2018

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Characterization of a cDNA encoding a new member of the glucocorticoid-responsive cytochromes P450 in human liver

21 January 2018

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Detection of CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein?

21 January 2018

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Regioselective biotransformation of midazolam by members of the human cytochrome P450 3A (CYP3A) subfamily

21 January 2018

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Cytochrome P450 in human fetal liver: significance and fetal-specific expression

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Purification and properties of cytochrome P-450 from homogenates of human fetal livers

21 January 2018

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Isolation and characterization of human fetal liver cytochrome P450HLp2: a third member of the P450III gene family

21 January 2018

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Four forms of cytochrome P-450 in human fetal liver: purification and their capacity to activate promutagens.

21 January 2018

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Paradoxical transcriptional activation of rat liver cytochrome P-450 3A1 by dexamethasone and the antiglucocorticoid pregnenolone 16 alpha-carbonitrile: analysis by transient transfection into primary monolayer cultures of adult rat hepatocytes

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Identification of a human nuclear receptor defines a new signaling pathway for CYP3A induction

21 January 2018

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Evidence for the presence of a functional pregnane X receptor response element in the CYP3A7 promoter gene

21 January 2018

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The RXR heterodimers and orphan receptors

21 January 2018

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P450 gene induction by structurally diverse xenochemicals: central role of nuclear receptors CAR, PXR, and PPAR.

21 January 2018

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Modification of clinical presentation of prostate tumors by a novel genetic variant in CYP3A4.

21 January 2018

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Gene structure of CYP3A4, an adult-specific form of cytochrome P450 in human livers, and its transcriptional control.

21 January 2018

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LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones

21 January 2018

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21 January 2018

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In vitro and in vivo drug interactions involving human CYP3A.

21 January 2018

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Noninvasive tests of CYP3A enzymes

21 January 2018

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21 January 2018

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Midazolam hydroxylation by human liver microsomes in vitro: inhibition by fluoxetine, norfluoxetine, and by azole antifungal agents

21 January 2018

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Metabolism of rifabutin in human enterocyte and liver microsomes: kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents

21 January 2018

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Inhibition of human CYP3A catalyzed 1'-hydroxy midazolam formation by ketoconazole, nifedipine, erythromycin, cimetidine, and nizatidine

21 January 2018

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Midazolam should be avoided in patients receiving the systemic antimycotics ketoconazole or itraconazole

21 January 2018

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Dose of midazolam should be reduced during diltiazem and verapamil treatments

21 January 2018

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A potentially hazardous interaction between erythromycin and midazolam

21 January 2018

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The contribution of intestinal and hepatic CYP3A to the interaction between midazolam and clarithromycin

21 January 2018

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Cytochrome P-450 complex formation by dirithromycin and other macrolides in rat and human livers

21 January 2018

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Inhibition of alfentanil metabolism by erythromycin

21 January 2018

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The role of cytochrome P450 3A4 in alfentanil clearance. Implications for interindividual variability in disposition and perioperative drug interactions

21 January 2018

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Isotope Effect Studies on the Cytochrome P450 Enzymes

21 January 2018

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Metabolism of the B-ring of testosterone by the rat cytochrome P-450 system

21 January 2018

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Activation of CYP3A4: evidence for the simultaneous binding of two substrates in a cytochrome P450 active site

21 January 2018

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Cooperativity in oxidations catalyzed by cytochrome P450 3A4.

21 January 2018

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CYP3A4 drug interactions: correlation of 10 in vitro probe substrates

21 January 2018

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Renal and hepatic family 3A cytochromes P450 (CYP3a) in spontaneously hypertensive rats

21 January 2018

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Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102338

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression

21 January 2018

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https://api.crossref.org/works/10.1081%2FDMR-100102338

Grapefruit juice activates P-glycoprotein-mediated drug transport

21 January 2018

1 reference

https://api.crossref.org/works/10.1081%2FDMR-100102338

21 January 2018

Identifiers

DOI

10.1081/DMR-100102338

1 reference

31 July 2017

1 reference