PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro (Q35089274)

6 August 2017

title

PIK3CA-mediated PI3-kinase signalling is essential for HPV-induced transformation in vitro (English)

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6 August 2017

author

Renske D. Steenbergen

object named as

Renske D M Steenbergen

1 reference

6 August 2017

Chris J L M Meijer

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6 August 2017

Peter J F Snijders

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6 August 2017

Florianne E Henken

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6 August 2017

N Sanjib Banerjee

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6 August 2017

Johanna De-Castro Arce

1 reference

6 August 2017

Frank Rösl

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6 August 2017

Thomas R Broker

1 reference

6 August 2017

Louise T Chow

1 reference

6 August 2017

publication date

10 June 2011

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6 August 2017

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6 August 2017

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6 August 2017

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PI3-kinase-dependent activation of apoptotic machinery occurs on commitment of epidermal keratinocytes to terminal differentiation

6 August 2017

cites work

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8 July 2018

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8 July 2018

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AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture.

8 July 2018

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Increased gene copy numbers at chromosome 20q are frequent in both squamous cell carcinomas and adenocarcinomas of the cervix

8 July 2018

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Phosphatidylinositol 3-kinase inhibition by LY294002 radiosensitizes human cervical cancer cell lines

8 July 2018

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The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells

8 July 2018

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Comparison of three different PCR methods for quantifying human papillomavirus type 16 DNA in cervical scrape specimens

8 July 2018

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Activation of the protein kinase B pathway by the HPV-16 E7 oncoprotein occurs through a mechanism involving interaction with PP2A

8 July 2018

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8 July 2018

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G1 cell cycle progression and the expression of G1 cyclins are regulated by PI3K/AKT/mTOR/p70S6K1 signaling in human ovarian cancer cells

8 July 2018

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TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia

8 July 2018

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Phosphatidylinositol 3-kinase mediates proliferative signals in intestinal epithelial cells

8 July 2018

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

8 July 2018

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Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells

8 July 2018

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Endogenous human papillomavirus E6 and E7 proteins differentially regulate proliferation, senescence, and apoptosis in HeLa cervical carcinoma cells

8 July 2018

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E7 abolishes raf-induced arrest via mislocalization of p21(Cip1).

8 July 2018

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The protein kinase B/Akt signalling pathway in human malignancy

8 July 2018

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HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation

8 July 2018

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Papillomavirus E2 induces senescence in HPV-positive cells via pRB- and p21(CIP)-dependent pathways

8 July 2018

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PIK3CA as an oncogene in cervical cancer

8 July 2018

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Viral E6-E7 transcription in the basal layer of organotypic cultures without apparent p21cip1 protein precedes immortalization of human papillomavirus type 16- and 18-transfected human keratinocytes

8 July 2018

1 reference

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Papillomavirus infections--a major cause of human cancers

8 July 2018

1 reference

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Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130697

Telomerase activation by the E6 gene product of human papillomavirus type 16.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130697

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

8 July 2018

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Correlation of modified human papilloma virus early gene expression with altered growth properties in C4-1 cervical carcinoma cells.

8 July 2018

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Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation

8 July 2018

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Expression of transketolase-like 1 (TKTL1) and p-Akt correlates with the progression of cervical neoplasia

21 January 2018

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Determination of viral load thresholds in cervical scrapings to rule out CIN 3 in HPV 16, 18, 31 and 33-positive women with normal cytology

21 January 2018

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Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death.

21 January 2018

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PIK3CA is implicated as an oncogene in ovarian cancer.

21 January 2018

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The E7 protein from human papillomavirus type 16 enhances keratinocyte migration in an Akt-dependent manner

21 January 2018

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https://api.crossref.org/works/10.1186%2F1476-4598-10-71

Alterations in AP-1 and AP-1 regulatory genes during HPV-induced carcinogenesis.

21 January 2018

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Molecular determinants of Akt-induced keratinocyte transformation

27 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3130697

Specific betapapillomaviruses associated with squamous cell carcinoma of the skin inhibit UVB-induced apoptosis of primary human keratinocytes

27 September 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-10-71

Human Papillomavirus Type 16 E7 Up-regulates AKT Activity through the Retinoblastoma Protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-10-71

Genetic alterations in cervical carcinomas: Frequent low-level amplifications of oncogenes are associated with human papillomavirus infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1186%2F1476-4598-10-71

Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21663621

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV e6‐e7 anti‐sense RNA

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21663621

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Advanced-stage cervical carcinomas are defined by a recurrent pattern of chromosomal aberrations revealing high genetic instability and a consistent gain of chromosome arm 3q

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21663621

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1476-4598-10-71

1 reference

Dimensions Publication ID

6 August 2017

0 references

1 reference

6 August 2017

1 reference