UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases. (Q35059350)

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English	UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases.	scientific article

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29 February 2020

UBE2L3 polymorphism amplifies NF-κB activation and promotes plasma cell development, linking linear ubiquitination to multiple autoimmune diseases (English)

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29 February 2020

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protein ubiquitination

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29 February 2020

Adrian M Shields

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29 February 2020

Sebastian Boeltz

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Timothy D Spector

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29 February 2020

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Simon Vyse

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29 February 2020

Patrick A Gordon

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29 February 2020

Henning Walczak

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29 February 2020

Timothy J Vyse

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29 February 2020

American Journal of Human Genetics

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29 February 2020

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29 February 2020

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29 February 2020

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Polarization of the effects of autoimmune and neurodegenerative risk alleles in leukocytes

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8 July 2018

The ubiquitin conjugating enzyme UBE2L3 regulates TNFα-induced linear ubiquitination

1 reference

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OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin

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8 July 2018

Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF-κB regulation

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8 July 2018

A20 inhibits LUBAC-mediated NF-κB activation by binding linear polyubiquitin chains via its zinc finger 7

1 reference

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8 July 2018

The E3 ligase HOIP specifies linear ubiquitin chain assembly through its RING-IBR-RING domain and the unique LDD extension.

1 reference

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8 July 2018

LUBAC synthesizes linear ubiquitin chains via a thioester intermediate

1 reference

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8 July 2018

A Human Ubiquitin Conjugating Enzyme (E2)-HECT E3 Ligase Structure-function Screen

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A functional haplotype of UBE2L3 confers risk for systemic lupus erythematosus

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SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

1 reference

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8 July 2018

Linear ubiquitination prevents inflammation and regulates immune signalling

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Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1

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Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus

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Disturbed peripheral B lymphocyte homeostasis in systemic lupus erythematosus

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1016/J.AJHG.2014.12.024

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29 February 2020

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29 February 2020

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29 February 2020

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