Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction (Q22001513)

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English	Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction	scientific article

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Recruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene induction (English)

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RANBP2-type and C3HC4-type zinc finger containing 1

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GOA release 2020-03-11

Ring finger protein 31

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GOA release 2020-03-11

T cell receptor signaling pathway

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GOA release 2020-03-11

12

object named as

David Komander

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David

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Komander

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PubMed publication ID

7 February 2023

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Björn Gerlach

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Björn

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Gerlach

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7 February 2023

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Tobias L Haas

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Tobias L

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Haas

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7 February 2023

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John Silke

13

author given names

John

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Silke

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7 February 2023

Henning Walczak

object named as

Henning Walczak

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Henning

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Walczak

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ORCID Public Data File 2021

PubMed publication ID

7 February 2023

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Christoph H Emmerich

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author given names

Christoph H

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Emmerich

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PubMed publication ID

7 February 2023

Anna C Schmukle

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author given names

Anna C

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Schmukle

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7 February 2023

Stefanie M Cordier

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author given names

Stefanie M

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Cordier

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7 February 2023

Eva Rieser

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author given names

Eva

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Rieser

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7 February 2023

Rebecca Feltham

7

author given names

Rebecca

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Feltham

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7 February 2023

James Vince

8

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James

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Vince

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7 February 2023

Uwe Warnken

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author given names

Uwe

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Warnken

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PubMed publication ID

7 February 2023

Till Wenger

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author given names

Till

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Wenger

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PubMed publication ID

7 February 2023

Ronald Koschny

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author given names

Ronald

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Koschny

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7 February 2023

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publication date

11 December 2009

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36

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5

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831-44

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The TNF receptor 1-associated protein TRADD signals cell death and NF-kappa B activation

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

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The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

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Polyubiquitin chains: polymeric protein signals

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IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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Shared principles in NF-kappaB signaling

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

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Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

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Receptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitro

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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The ubiquitin-editing enzyme A20 restricts nucleotide-binding oligomerization domain containing 2-triggered signals

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

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based on heuristic

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Structural basis for bivalent Smac-mimetics recognition in the IAP protein family

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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If the prophet does not come to the mountain: dynamics of signaling complexes in NF-kappaB activation

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

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Structural Basis for Recognition of Diubiquitins by NEMO

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Nonproteolytic functions of ubiquitin in cell signaling

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

The TNF and TNF receptor superfamilies: integrating mammalian biology

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

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based on heuristic

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The distinct roles of TRAF2 and RIP in IKK activation by TNF-R1: TRAF2 recruits IKK to TNF-R1 while RIP mediates IKK activation

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

TRAF2 is essential for JNK but not NF-kappaB activation and regulates lymphocyte proliferation and survival

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

The death domain kinase RIP mediates the TNF-induced NF-kappaB signal

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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NEMO/IKK gamma-deficient mice model incontinentia pigmenti.

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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Structural Basis for the Lack of E2 Interaction in the RING Domain of TRAF2

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

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Design, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAP

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

A generic protein purification method for protein complex characterization and proteome exploration

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Atypical ubiquitin chains: new molecular signals. 'Protein Modifications: Beyond the Usual Suspects' review series

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Linear polyubiquitination: a new regulator of NF-kappaB activation.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin signalling in the NF-kappaB pathway

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

NF-kappaB at the crossroads of life and death

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Essential function for the kinase TAK1 in innate and adaptive immune responses

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Function of TRADD in tumor necrosis factor receptor 1 signaling and in TRIF-dependent inflammatory responses

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin and ubiquitin-like proteins in cancer pathogenesis

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Tumor necrosis factor signaling.

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin, TAK1 and IKK: is there a connection?

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

A ubiquitin ligase complex assembles linear polyubiquitin chains

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

NF-kappaB inhibition reveals differential mechanisms of TNF versus TRAIL-induced apoptosis upstream or at the level of caspase-8 activation independent of cIAP2.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Signal processing by its coil zipper domain activates IKK gamma

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Both cIAP1 and cIAP2 regulate TNFalpha-mediated NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex

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https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (tnf) to efficiently activate nf-{kappa}b and to prevent tnf-induced apoptosis.

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Ubiquitination of RIP Is Required for Tumor Necrosis Factor α-induced NF-κB Activation

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment

1 reference

https://api.crossref.org/works/10.1016%2FJ.MOLCEL.2009.10.013

7 January 2021

based on heuristic

inferred from DOI database lookup

TAK1, but not TAB1 or TAB2, plays an essential role in multiple signaling pathways in vivo

1 reference

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7 January 2021

based on heuristic

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1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

TNF-R1 signaling: a beautiful pathway

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7 January 2021

based on heuristic

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Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

SM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP.

1 reference

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based on heuristic

inferred from DOI database lookup

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