Use of a physiologically based pharmacokinetic model for rats to study the influence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD. (Q35039205)

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English	Use of a physiologically based pharmacokinetic model for rats to study the influence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD.	scientific article

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30 December 2019

Use of a physiologically based pharmacokinetic model for rats to study the influence of body fat mass and induction of CYP1A2 on the pharmacokinetics of TCDD (English)

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30 December 2019

pharmacokinetics

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2

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30 December 2019

Michael J DeVito

3

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30 December 2019

author name string

Claude Emond

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30 December 2019

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1 September 2006

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30 December 2019

Environmental Health Perspectives

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30 December 2019

114

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30 December 2019

9

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30 December 2019

1394-1400

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30 December 2019

Comparison of the use of a physiologically based pharmacokinetic model and a classical pharmacokinetic model for dioxin exposure assessments

1 reference

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Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals

1 reference

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Meta-analysis of dioxin cancer dose response for three occupational cohorts

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Metabolic pathways of dioxin by CYP1A1: species difference between rat and human CYP1A subfamily in the metabolism of dioxins

1 reference

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8 July 2018

Pharmacokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso adults and veterans of operation Ranch Hand

1 reference

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Risk assessment for 2,3,7,8-p-dioxin (TCDD) based on an epidemiologic study

1 reference

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8 July 2018

Hepatic cytochrome P450 regulation in disease states

1 reference

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Extrapolation of a PBPK model for dioxins across dosage regimen, gender, strain, and species

1 reference

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8 July 2018

Effects of CYP1A2 on disposition of 2,3,7, 8-tetrachlorodibenzo-p-dioxin, 2,3,4,7,8-pentachlorodibenzofuran, and 2,2',4,4',5,5'-hexachlorobiphenyl in CYP1A2 knockout and parental (C57BL/6N and 129/Sv) strains of mice

1 reference

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8 July 2018

The estimation of elimination rates of persistent compounds: a re-analysis of 2,3,7,8-tetrachlorodibenzo-p-dioxin levels in Vietnam veterans

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8 July 2018

A pharmacodynamic analysis of TCDD-induced cytochrome P450 gene expression in multiple tissues: dose- and time-dependent effects

1 reference

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8 July 2018

Regional hepatic CYP1A1 and CYP1A2 induction with 2,3,7,8-tetrachlorodibenzo-p-dioxin evaluated with a multicompartment geometric model of hepatic zonation.

1 reference

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8 July 2018

Differential time-course and dose-response relationships of TCDD-induced CYP1B1, CYP1A1, and CYP1A2 proteins in rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570044

8 July 2018

Modeling of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. II. Kinetics of absorption and disposition of PCDDs/PCDFs

1 reference

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8 July 2018

Modeling of the toxicokinetics of polychlorinated dibenzo-p-dioxins and dibenzofurans in mammalians, including humans. I. Nonlinear distribution of PCDD/PCDF body burden between liver and adipose tissues

1 reference

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8 July 2018

Dioxins: model chemicals for assessing receptor-mediated toxicity.

1 reference

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8 July 2018

Excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570044

8 July 2018

Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. 1. Dose-dependent tissue distribution and induction of hepatic ethoxyresorufin O-deethylase in rats following a single injection.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1570044

8 July 2018

Tissue distribution, metabolism, and excretion of 14C-TCDD in a TCDD-susceptible and a TCDD-resistant rat strain.

1 reference

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8 July 2018

Disposition of 2,3,7,8-tetrabromodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat: biliary excretion and induction of cytochromes CYP1A1 and CYP1A2.

1 reference

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Concentration-dependent TCDD elimination kinetics in humans: toxicokinetic modeling for moderately to highly exposed adults from Seveso, Italy, and Vienna, Austria, and impact on dose estimates for the NIOSH cohort

1 reference

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25 October 2018

Physiologically based pharmacokinetic model for developmental exposures to TCDD in the rat.

1 reference

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Severe 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) intoxication: insights into the measurement of hepatic cytochrome P450 1A2 induction

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1 reference

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Subchronic Exposure of [3H]- 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in female B6C3F1 mice: relationship of steady-state levels to disposition and metabolism.

1 reference

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1 reference

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25 October 2018

Tissue distribution and toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats after intravenous injection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16966094

12 December 2020

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Hepatic uptake and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-tetrachlorodibenzofuran

1 reference

https://pubmed.ncbi.nlm.nih.gov/16966094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A mechanistic model of effects of dioxin on thyroid hormones in the rat

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https://pubmed.ncbi.nlm.nih.gov/16966094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Elimination of polychlorinated dibenzo-p-dioxins and dibenzofurans in occupationally exposed persons

1 reference

https://pubmed.ncbi.nlm.nih.gov/16966094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Toxicokinetics of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in two substrains of male Long-Evans rats after intravenous injection

1 reference

https://pubmed.ncbi.nlm.nih.gov/16966094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determination of parameters responsible for pharmacokinetic behavior of TCDD in female Sprague-Dawley rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/16966094

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Estimation of dioxin and furan elimination rates with a pharmacokinetic model

1 reference

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Tissue distribution, excretion and biological effects of [14C]tetrachlorodibenzo-p-dioxin in rats

1 reference

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Influence of phenobarbital and TCDD on the hepatic metabolism of TCDD in the dog

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Studies on the mechanism of absorption and distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat

1 reference

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Characterization of the Dose–Response of CYP1B1, CYP1A1, and CYP1A2 in the Liver of Female Sprague–Dawley Rats Following Chronic Exposure to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1 reference

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1 reference

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Identifiers

10.1289/EHP.8805

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30 December 2019

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30 December 2019

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30 December 2019

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