Distribution and functions of sterols and sphingolipids (Q35006514)

5 August 2017

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title

Distribution and functions of sterols and sphingolipids (English)

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5 August 2017

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5 August 2017

J Thomas Hannich

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5 August 2017

Kyohei Umebayashi

series ordinal

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5 August 2017

publication date

1 May 2011

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Cold Spring Harbor Perspectives in Biology

5 August 2017

published in

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5 August 2017

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5 August 2017

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Shotgun lipidomics on high resolution mass spectrometers

5 August 2017

cites work

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Survival strategies of a sterol auxotroph

8 July 2018

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Structure and function of sphingosine-1-phosphate lyase, a key enzyme of sphingolipid metabolism

8 July 2018

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Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

8 July 2018

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An update on sphingosine-1-phosphate and other sphingolipid mediators

8 July 2018

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Marine antifungal theonellamides target 3beta-hydroxysterol to activate Rho1 signaling

8 July 2018

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Phylogenetic distribution of fungal sterols

8 July 2018

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Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

8 July 2018

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Phylogenomics of sterol synthesis: insights into the origin, evolution, and diversity of a key eukaryotic feature

8 July 2018

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Cholesterol trafficking is required for mTOR activation in endothelial cells

8 July 2018

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Revealing a signaling role of phytosphingosine-1-phosphate in yeast

8 July 2018

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Structure of sterol aliphatic chains affects yeast cell shape and cell fusion during mating

8 July 2018

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A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy

8 July 2018

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A critical role for ceramide synthase 2 in liver homeostasis: I. alterations in lipid metabolic pathways

8 July 2018

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Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids

8 July 2018

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The compartmentalized bacteria of the planctomycetes-verrucomicrobia-chlamydiae superphylum have membrane coat-like proteins

8 July 2018

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Lipid rafts as a membrane-organizing principle

8 July 2018

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Plant sphingolipids: decoding the enigma of the Sphinx

8 July 2018

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Evolutionary conservation and adaptation in the mechanism that regulates SREBP action: what a long, strange tRIP it's been

8 July 2018

1 reference

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Schlank, a member of the ceramide synthase family controls growth and body fat in Drosophila

8 July 2018

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Adult ceramide synthase 2 (CERS2)-deficient mice exhibit myelin sheath defects, cerebellar degeneration, and hepatocarcinomas

8 July 2018

1 reference

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Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.

8 July 2018

1 reference

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Amino acid-containing membrane lipids in bacteria.

8 July 2018

1 reference

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A review of lipidomic technologies applicable to sphingolipidomics and their relevant applications

8 July 2018

1 reference

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Identification of cholesterol-regulating genes by targeted RNAi screening

8 July 2018

1 reference

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Special relationship between sterols and oxygen: were sterols an adaptation to aerobic life?

8 July 2018

1 reference

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Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

8 July 2018

1 reference

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Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network

8 July 2018

1 reference

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A molecular barcoded yeast ORF library enables mode-of-action analysis of bioactive compounds

8 July 2018

1 reference

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Intracellular sterol dynamics

8 July 2018

1 reference

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Expression of ceramide glucosyltransferases, which are essential for glycosphingolipid synthesis, is only required in a small subset of C. elegans cells

8 July 2018

1 reference

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Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology

8 July 2018

1 reference

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Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry

8 July 2018

1 reference

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Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis

8 July 2018

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Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance

8 July 2018

1 reference

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Sphingolipidomics: a valuable tool for understanding the roles of sphingolipids in biology and disease

8 July 2018

1 reference

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TOR1 and TOR2 have distinct locations in live cells

8 July 2018

1 reference

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Preservation of genes involved in sterol metabolism in cholesterol auxotrophs: facts and hypotheses

8 July 2018

1 reference

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Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeast

8 July 2018

1 reference

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Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Yeast ARV1 is required for efficient delivery of an early GPI intermediate to the first mannosyltransferase during GPI assembly and controls lipid flow from the endoplasmic reticulum

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Regulation of ceramide biosynthesis by TOR complex 2.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Principles of bioactive lipid signalling: lessons from sphingolipids

8 July 2018

1 reference

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Genome-wide analysis of sterol-lipid storage and trafficking in Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Sphingolipids and membrane biology as determined from genetic models

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Structure-specific, quantitative methods for analysis of sphingolipids by liquid chromatography-tandem mass spectrometry: "inside-out" sphingolipidomics

8 July 2018

1 reference

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Alkaline methanolysis of lipid extracts extends shotgun lipidomics analyses to the low-abundance regime of cellular sphingolipids

8 July 2018

1 reference

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Lanosterol biosynthesis in the prokaryote Methylococcus capsulatus: insight into the evolution of sterol biosynthesis

8 July 2018

1 reference

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The structure of serine palmitoyltransferase; gateway to sphingolipid biosynthesis

8 July 2018

1 reference

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Function of the MAPK scaffold protein, Ste5, requires a cryptic PH domain

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Functions and metabolism of sphingolipids in Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast.

8 July 2018

1 reference

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Sphingoid base is required for translation initiation during heat stress in Saccharomyces cerevisiae

8 July 2018

1 reference

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The ins and outs of sphingolipid synthesis

8 July 2018

1 reference

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Enzymes of sphingolipid metabolism in Drosophila melanogaster

8 July 2018

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Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae

8 July 2018

1 reference

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Molecular machinery for non-vesicular trafficking of ceramide

8 July 2018

1 reference

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Phylogenetic and biochemical evidence for sterol synthesis in the bacterium Gemmata obscuriglobus

8 July 2018

1 reference

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Protein sorting in the late Golgi of Saccharomyces cerevisiae does not require mannosylated sphingolipids.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

THE UTILIZATION OF STEROLS BY INSECTS

8 July 2018

1 reference

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Why do worms need cholesterol?

8 July 2018

1 reference

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Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Plant sphingolipids: structural diversity, biosynthesis, first genes and functions

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Sterols in microorganisms

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Cell surface polarization during yeast mating

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Multiple functions of sterols in yeast endocytosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Membrane-bound enzymes of cholesterol synthesis from lanosterol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Vesicular and nonvesicular transport of ceramide from ER to the Golgi apparatus in yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Sphingoid base signaling via Pkh kinases is required for endocytosis in yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Glycosphingolipids are required for sorting melanosomal proteins in the Golgi complex

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Do sterols reduce proton and sodium leaks through lipid bilayers?

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Increased protein kinase or decreased PP2A activity bypasses sphingoid base requirement in endocytosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Sphingoid base synthesis requirement for endocytosis in Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Sli2 (Ypk1), a homologue of mammalian protein kinase SGK, is a downstream kinase in the sphingolipid-mediated signaling pathway of yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Lipid rafts function in biosynthetic delivery of proteins to the cell surface in yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Specific sterols required for the internalization step of endocytosis in yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Mutations in a delta 8-delta 7 sterol isomerase in the tattered mouse and X-linked dominant chondrodysplasia punctata. jderry@immunex.com

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Metabolism and selected functions of sphingolipids in the yeast Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Molecular genetics of the Smith-Lemli-Opitz syndrome and postsqualene sterol metabolism

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Membrane recruitment of the kinase cascade scaffold protein Ste5 by the Gbetagamma complex underlies activation of the yeast pheromone response pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

SUR1 (CSG1/BCL21), a gene necessary for growth of Saccharomyces cerevisiae in the presence of high Ca2+ concentrations at 37 degrees C, is required for mannosylation of inositolphosphorylceramide.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Lipid remodeling leads to the introduction and exchange of defined ceramides on GPI proteins in the ER and Golgi of Saccharomyces cerevisiae

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Emopamil-binding protein, a mammalian protein that binds a series of structurally diverse neuroprotective agents, exhibits delta8-delta7 sterol isomerase activity in yeast

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Endocytosis is required for the growth of vacuolar H(+)-ATPase-defective yeast: identification of six new END genes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

The yeast spt14 gene is homologous to the human PIG-A gene and is required for GPI anchor synthesis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

The yeast gene ERG6 is required for normal membrane function but is not essential for biosynthesis of the cell-cycle-sparking sterol

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Mannosylinositol phosphorylceramide is a major sphingolipid component and is required for proper localization of plasma-membrane proteins in Schizosaccharomyces pombe

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Sorting defects of the tryptophan permease Tat2 in an erg2 yeast mutant

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Methylation of the sterol nucleus by STRM-1 regulates dauer larva formation in Caenorhabditis elegans.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Protection of C. elegans from anoxia by HYL-2 ceramide synthase

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Concentration of GPI-anchored proteins upon ER exit in yeast

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Very long-chain fatty acid-containing lipids rather than sphingolipids per se are required for raft association and stable surface transport of newly synthesized plasma membrane ATPase in yeast.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Identification of fungal sphingolipid C9-methyltransferases by phylogenetic profiling

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

The sphingoid long chain base phytosphingosine activates AGC-type protein kinases in Saccharomyces cerevisiae including Ypk1, Ypk2, and Sch9.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Synthesis of sphingolipids with very long chain fatty acids but not ergosterol is required for routing of newly synthesized plasma membrane ATPase to the cell surface of yeast.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Sphingolipids are required for the stable membrane association of glycosylphosphatidylinositol-anchored proteins in yeast

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

ERG6 and PDR5 regulate small lipophilic drug accumulation in yeast cells via distinct mechanisms

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Ceramide biosynthesis is required for the formation of the oligomeric H+-ATPase Pma1p in the yeast endoplasmic reticulum

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

In situ detection of prolactin receptor mRNA and apoptotic cell death in mouse uterine tissues with adenomyosis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Isoprene synthesis in isolated embryonic Drosophila cells. I. Sterol-deficient eukaryotic cells.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3101845

Selection of yeast mutants in sphingolipid metabolism

26 October 2018

1 reference

12 December 2020

The glycosylceramides of the nematodeCaenorhabditis elegans contain an unusual, branched‐chain sphingoid base

1 reference

12 December 2020

Steroids and Squalene in Methylococcus capsulatus grown on Methane

1 reference

12 December 2020

Inhibition of amino acid transport by sphingoid long chain bases in Saccharomyces cerevisiae

1 reference

12 December 2020

10.1101/CSHPERSPECT.A004762

Identifiers

DOI

1 reference

5 August 2017

1 reference

5 August 2017

1 reference