Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins (Q36927976)

17 August 2017

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title

Emergence of a DNA-damage response network consisting of Fanconi anaemia and BRCA proteins (English)

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17 August 2017

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Weidong Wang

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17 August 2017

publication date

4 September 2007

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17 August 2017

published in

Nature Reviews Genetics

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17 August 2017

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17 August 2017

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17 August 2017

page(s)

735-748

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Repair of DNA interstrand cross-links

17 August 2017

cites work

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Interstrand cross-links induce DNA synthesis in damaged and undamaged plasmids in mammalian cell extracts

21 January 2018

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Fanconi anemia proteins FANCA, FANCC, and FANCG/XRCC9 interact in a functional nuclear complex

21 January 2018

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DNA interstrand cross-link repair in the cell cycle: a critical role for polymerase zeta in G1 phase

21 January 2018

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Inducibility of nuclear Rad51 foci after DNA damage distinguishes all Fanconi anemia complementation groups from D1/BRCA2.

21 January 2018

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Molecular cloning of Drosophila mus308, a gene involved in DNA cross-link repair with homology to prokaryotic DNA polymerase I genes

21 January 2018

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Interaction of the Fanconi anemia proteins and BRCA1 in a common pathway

21 January 2018

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Biallelic inactivation of BRCA2 in Fanconi anemia

31 March 2020

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Functional interaction of monoubiquitinated FANCD2 and BRCA2/FANCD1 in chromatin

31 March 2020

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Tracing the network connecting BRCA and Fanconi anaemia proteins

31 March 2020

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The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J

31 March 2020

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The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia

31 March 2020

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BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.

31 March 2020

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Fanconi anemia is associated with a defect in the BRCA2 partner PALB2.

31 March 2020

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Biallelic mutations in PALB2 cause Fanconi anemia subtype FA-N and predispose to childhood cancer

31 March 2020

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PALB2, which encodes a BRCA2-interacting protein, is a breast cancer susceptibility gene

31 March 2020

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A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M

31 March 2020

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The vertebrate Hef ortholog is a component of the Fanconi anemia tumor-suppressor pathway.

31 March 2020

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The DNA crosslink-induced S-phase checkpoint depends on ATR-CHK1 and ATR-NBS1-FANCD2 pathways

31 March 2020

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ATR couples FANCD2 monoubiquitination to the DNA-damage response

31 March 2020

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Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells

31 March 2020

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The Fanconi anaemia gene FANCC promotes homologous recombination and error-prone DNA repair

31 March 2020

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Human Fanconi anemia monoubiquitination pathway promotes homologous DNA repair

31 March 2020

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The emerging genetic and molecular basis of Fanconi anaemia

31 March 2020

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The 4N cell cycle delay in Fanconi anemia reflects growth arrest in late S phase

31 March 2020

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Functional relationships of FANCC to homologous recombination, translesion synthesis, and BLM

31 March 2020

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A Multiprotein Nuclear Complex Connects Fanconi Anemia and Bloom Syndrome

31 March 2020

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Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM.

31 March 2020

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FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway

31 March 2020

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BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity

31 March 2020

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The Fanconi Anemia/BRCA pathway: new faces in the crowd

31 March 2020

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Disruption of the Fanconi anemia-BRCA pathway in cisplatin-sensitive ovarian tumors

31 March 2020

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Analysis of the Fanconi anaemia complementation group A gene in acute myeloid leukaemia.

31 March 2020

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Deletion and reduced expression of the Fanconi anemia FANCA gene in sporadic acute myeloid leukemia

31 March 2020

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Hallmarks of 'BRCAness' in sporadic cancers

31 March 2020

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Chemosensitization to cisplatin by inhibitors of the Fanconi anemia/BRCA pathway

31 March 2020

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Cloning of cDNAs for Fanconi's anaemia by functional complementation

31 March 2020

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Evidence for at least four Fanconi anaemia genes including FACC on chromosome 9

31 March 2020

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Expression cloning of a cDNA for the major Fanconi anaemia gene, FAA.

31 March 2020

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Positional cloning of the Fanconi anaemia group A gene

31 March 2020

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The Fanconi anaemia group G gene FANCG is identical with XRCC9

31 March 2020

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The Fanconi anaemia gene FANCF encodes a novel protein with homology to ROM

31 March 2020

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Isolation of a cDNA representing the Fanconi anemia complementation group E gene

31 March 2020

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The Fanconi anaemia proteins, FAA and FAC, interact to form a nuclear complex

31 March 2020

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The Fanconi anemia protein FANCF forms a nuclear complex with FANCA, FANCC and FANCG

31 March 2020

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Direct interactions of the five known Fanconi anaemia proteins suggest a common functional pathway

31 March 2020

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Positional cloning of a novel Fanconi anemia gene, FANCD2

31 March 2020

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S-phase-specific interaction of the Fanconi anemia protein, FANCD2, with BRCA1 and RAD51

31 March 2020

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Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair

31 March 2020

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FANCI is a second monoubiquitinated member of the Fanconi anemia pathway

31 March 2020

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A novel ubiquitin ligase is deficient in Fanconi anemia

31 March 2020

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X-linked inheritance of Fanconi anemia complementation group B

31 March 2020

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Control of BRCA2 cellular and clinical functions by a nuclear partner, PALB2.

31 March 2020

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The WD40 repeats of FANCL are required for Fanconi anemia core complex assembly

31 March 2020

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FANCE: the link between Fanconi anaemia complex assembly and activity

31 March 2020

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Novel endonuclease in Archaea cleaving DNA with various branched structure

31 March 2020

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Cooperation of the N-terminal Helicase and C-terminal endonuclease activities of Archaeal Hef protein in processing stalled replication forks

31 March 2020

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Saccharomyces cerevisiae MPH1 gene, required for homologous recombination-mediated mutation avoidance, encodes a 3' to 5' DNA helicase

31 March 2020

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DNA structure-induced recruitment and activation of the Fanconi anemia pathway protein FANCD2

31 March 2020

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The fanconi anemia pathway requires FAA phosphorylation and FAA/FAC nuclear accumulation

31 March 2020

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Phosphorylation of fanconi anemia (FA) complementation group G protein, FANCG, at serine 7 is important for function of the FA pathway

31 March 2020

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Chk1-mediated phosphorylation of FANCE is required for the Fanconi anemia/BRCA pathway

31 March 2020

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ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

31 March 2020

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The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway

31 March 2020

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Convergence of the fanconi anemia and ataxia telangiectasia signaling pathways

31 March 2020

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Direct DNA binding activity of the Fanconi anemia D2 protein.

31 March 2020

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A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair

31 March 2020

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Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability

31 March 2020

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Multiple repair pathways mediate tolerance to chemotherapeutic cross-linking agents in vertebrate cells.

31 March 2020

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REV3 and REV1 play major roles in recombination-independent repair of DNA interstrand cross-links mediated by monoubiquitinated proliferating cell nuclear antigen (PCNA).

31 March 2020

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Interaction of human DNA polymerase eta with monoubiquitinated PCNA: a possible mechanism for the polymerase switch in response to DNA damage

31 March 2020

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Hypomorphic mutations in the gene encoding a key Fanconi anemia protein, FANCD2, sustain a significant group of FA-D2 patients with severe phenotype

31 March 2020

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Epithelial cancer in Fanconi anemia complementation group D2 (Fancd2) knockout mice

31 March 2020

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Multifactorial contributions to an acute DNA damage response by BRCA1/BARD1-containing complexes

31 March 2020

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Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response

31 March 2020

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RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites

31 March 2020

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Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response

31 March 2020

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The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells

31 March 2020

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Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

31 March 2020

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BRCA2 function in DNA binding and recombination from a BRCA2-DSS1-ssDNA structure

31 March 2020

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Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

31 March 2020

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BRCA2 is required for homology-directed repair of chromosomal breaks

31 March 2020

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The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair

31 March 2020

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The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations

31 March 2020

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POLQ (Pol theta), a DNA polymerase and DNA-dependent ATPase in human cells

31 March 2020

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The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm

31 March 2020

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Archaeal Hel308 helicase targets replication forks in vivo and in vitro and unwinds lagging strands

31 March 2020

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Fanconi anemia proteins are required to prevent accumulation of replication-associated DNA double-strand breaks

31 March 2020

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Interaction of FANCD2 and NBS1 in the DNA damage response

31 March 2020

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Nbs1 is required for ATR-dependent phosphorylation events

31 March 2020

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HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability

31 March 2020

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Phosphorylation of FANCD2 on two novel sites is required for mitomycin C resistance

31 March 2020

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DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1.

31 March 2020

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Mechanistically distinct roles for Sgs1p in checkpoint activation and replication fork maintenance.

31 March 2020

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How Fanconi anemia proteins promote the four Rs: replication, recombination, repair, and recovery

31 March 2020

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UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation

31 March 2020

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Fanconi anemia (cross)linked to DNA repair

31 March 2020

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Repair of an interstrand DNA cross-link initiated by ERCC1-XPF repair/recombination nuclease.

31 March 2020

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The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRG2159

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17 August 2017

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