Identification of potential synthetic lethal genes to p53 using a computational biology approach (Q34985284)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

title

Identification of potential synthetic lethal genes to p53 using a computational biology approach (English)

1 reference

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20 February 2020

main subject

RNA sequencing

0 references

computational biology

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

Richard Simon

1 reference

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20 February 2020

publication date

11 September 2013

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20 February 2020

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20 February 2020

volume

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20 February 2020

page(s)

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SAPK pathways and p53 cooperatively regulate PLK4 activity and centrosome integrity under stress

20 February 2020

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A novel Aurora-A-mediated phosphorylation of p53 inhibits its interaction with MDM2.

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Mitotic Kinases and p53 Signaling

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Automated screening of microtubule growth dynamics identifies MARK2 as a regulator of leading edge microtubules downstream of Rac1 in migrating cells

8 July 2018

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ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53.

8 July 2018

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Cyclin-dependent kinase 16/PCTAIRE kinase 1 is activated by cyclin Y and is essential for spermatogenesis

8 July 2018

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8 July 2018

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A systematic RNAi synthetic interaction screen reveals a link between p53 and snoRNP assembly

8 July 2018

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Raf kinases in cancer-roles and therapeutic opportunities

8 July 2018

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A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations.

8 July 2018

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8 July 2018

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Polo-like kinase-1 as a novel target in neoplastic mast cells: demonstration of growth-inhibitory effects of small interfering RNA and the Polo-like kinase-1 targeting drug BI 2536.

8 July 2018

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p53-Reactivating small molecules induce apoptosis and enhance chemotherapeutic cytotoxicity in head and neck squamous cell carcinoma

8 July 2018

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Synthetic lethal interactions for the development of cancer therapeutics: biological and methodological advancements

8 July 2018

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Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers

8 July 2018

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Sensitivity of cancer cells to Plk1 inhibitor GSK461364A is associated with loss of p53 function and chromosome instability

8 July 2018

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p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment

8 July 2018

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The p53 response element and transcriptional repression

8 July 2018

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Aurora kinase inhibitors--rising stars in cancer therapeutics?

8 July 2018

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Regulation of Akt(ser473) phosphorylation by choline kinase in breast carcinoma cells

8 July 2018

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Transcriptional control of the proliferation cluster by the tumor suppressor p53.

8 July 2018

1 reference

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Differential role of human choline kinase alpha and beta enzymes in lipid metabolism: implications in cancer onset and treatment

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

CellMiner: a relational database and query tool for the NCI-60 cancer cell lines

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene

8 July 2018

1 reference

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Analysis of gene expression data using BRB-ArrayTools.

8 July 2018

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Targeting the mTOR signaling network for cancer therapy

8 July 2018

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TTK/hMps1 mediates the p53-dependent postmitotic checkpoint by phosphorylating p53 at Thr18.

8 July 2018

1 reference

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Methodological approaches in application of synthetic lethality screening towards anticancer therapy

8 July 2018

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p53-dependent apoptosis in response to spindle damage is linked to loss of Bub1.

8 July 2018

1 reference

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A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53

8 July 2018

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Centrosome-associated regulators of the G(2)/M checkpoint as targets for cancer therapy

8 July 2018

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Integrated genomic and pharmacological approaches to identify synthetic lethal genes as cancer therapeutic targets

8 July 2018

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Cdc7-Dbf4 kinase overexpression in multiple cancers and tumor cell lines is correlated with p53 inactivation

8 July 2018

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Choline kinase as a link connecting phospholipid metabolism and cell cycle regulation: implications in cancer therapy.

8 July 2018

1 reference

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Plk4-induced centriole biogenesis in human cells

8 July 2018

1 reference

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TP53 mutation status and gene expression profiles are powerful prognostic markers of breast cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Surveillance mechanism linking Bub1 loss to the p53 pathway

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Restoration of wild-type p53 function in human tumors: strategies for efficient cancer therapy.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Transcription regulation by mutant p53.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Restoration of p53 function leads to tumour regression in vivo

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Restoration of wild-type p53 function in human cancer: relevance for tumor therapy.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Gene expression patterns associated with p53 status in breast cancer.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

RB silencing compromises the DNA damage-induced G2/M checkpoint and causes deregulated expression of the ECT2 oncogene

8 July 2018

1 reference

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Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Mutant p53 induces the GEF-H1 oncogene, a guanine nucleotide exchange factor-H1 for RhoA, resulting in accelerated cell proliferation in tumor cells

8 July 2018

1 reference

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The promoters of human cell cycle genes integrate signals from two tumor suppressive pathways during cellular transformation.

8 July 2018

1 reference

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Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features

8 July 2018

1 reference

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RNA interference-mediated choline kinase suppression in breast cancer cells induces differentiation and reduces proliferation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Mutant human tumor suppressor p53 modulates the activation of mitogen-activated protein kinase and nuclear factor-kappaB, but not c-Jun N-terminal kinase and activated protein-1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

The concept of synthetic lethality in the context of anticancer therapy

8 July 2018

1 reference

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The coordinate regulation of the p53 and mTOR pathways in cells

8 July 2018

1 reference

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Protein kinase C (PKC) family in cancer progression

8 July 2018

1 reference

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Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells

8 July 2018

1 reference

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Upstream and downstream of mTOR

8 July 2018

1 reference

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Aurora A, meiosis and mitosis

8 July 2018

1 reference

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Polo-like kinases and the orchestration of cell division

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes.

8 July 2018

1 reference

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The functional interactions between the p53 and MAPK signaling pathways

8 July 2018

1 reference

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Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development

8 July 2018

1 reference

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Targeting mTOR signaling for cancer therapy

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Polo-like kinase (Plk)1 depletion induces apoptosis in cancer cells

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Mutations in PRKCSH cause isolated autosomal dominant polycystic liver disease

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Control of the eukaryotic cell cycle by MAP kinase signaling pathways.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Sustained activation of Ras/Raf/mitogen-activated protein kinase cascade by the tumor suppressor p53.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

A serine kinase regulates intracellular localization of splicing factors in the cell cycle

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Gene transfer of wild-type p53 results in restoration of tumor-suppressor function in a medulloblastoma cell line.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Mutations in the KRAS2 oncogene during progressive stages of human colon carcinoma

8 July 2018

1 reference

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Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

p53 mutations in human cancers

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3847148

Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis

8 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1755-8794-6-30

Targeting the protein kinase C family: are we there yet?

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1186%2F1755-8794-6-30

The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1

21 January 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24025726

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Restoration of the transcription activation function to mutant p53 in human cancer cells

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/24025726

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1186/1755-8794-6-30

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

20 February 2020

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

24025726

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24025726%20AND%20SRC:MED&resulttype=core&format=json