The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein. (Q33914706)

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9 November 2019

title

The human vaccinia-related kinase 1 (VRK1) phosphorylates threonine-18 within the mdm-2 binding site of the p53 tumour suppressor protein (English)

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9 November 2019

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9 November 2019

S Lopez-Borges

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9 November 2019

language of work or name

English

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publication date

1 July 2000

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9 November 2019

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9 November 2019

volume

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9 November 2019

issue

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9 November 2019

page(s)

3656-3664

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Vaccinia virus gene B1R encodes a 34-kDa serine/threonine protein kinase that localizes in cytoplasmic factories and is packaged into virions

9 November 2019

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Akt activation by growth factors is a multiple-step process: the role of the PH domain

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Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

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Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation

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Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

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Mapping of the p53 and mdm-2 Interaction Domains

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Nuclear targeting sequences--a consensus?

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Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2.

21 January 2018

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The complexity of p53 modulation: emerging patterns from divergent signals

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Role of COOH-terminal Phosphorylation in the Regulation of Casein Kinase Iδ

21 January 2018

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ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.

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DNA damage-induced activation of p53 by the checkpoint kinase Chk2

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Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling

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Transcriptional control by protein phosphorylation: signal transmission from the cell surface to the nucleus

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The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon

21 January 2018

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p53 is phosphorylated in vitro and in vivo by the delta and epsilon isoforms of casein kinase 1 and enhances the level of casein kinase 1 delta in response to topoisomerase-directed drugs

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p53: puzzle and paradigm

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p53 Is Phosphorylated by CDK7-Cyclin H in a p36MAT1-Dependent Manner

21 January 2018

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Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain

21 January 2018

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The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53.

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Regulation of p53 in response to DNA damage

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p53, the cellular gatekeeper for growth and division

21 January 2018

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Several hydrophobic amino acids in the p53 amino-terminal domain are required for transcriptional activation, binding to mdm-2 and the adenovirus 5 E1B 55-kD protein

21 January 2018

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Multisite phosphorylation and the integration of stress signals at p53.

21 January 2018

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Mechanisms of switching on p53: a role for covalent modification?

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Two-way trafficking with Ran.

21 January 2018

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p53 is phosphorylated in vitro and in vivo by an ultraviolet radiation-induced protein kinase characteristic of the c-Jun kinase, JNK1.

21 January 2018

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Identification of Two Novel Human Putative Serine/Threonine Kinases, VRK1 and VRK2, with Structural Similarity to Vaccinia Virus B1R Kinase

21 January 2018

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double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation

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Damage-mediated phosphorylation of human p53 threonine 18 through a cascade mediated by a casein 1-like kinase. Effect on Mdm2 binding

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DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2

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DNA damage-inducible phosphorylation of p53 at N-terminal sites including a novel site, Ser20, requires tetramerization

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DNA damage induces phosphorylation of the amino terminus of p53

21 January 2018

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P19(ARF) stabilizes p53 by blocking nucleo-cytoplasmic shuttling of Mdm2

21 January 2018

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Mutations in serines 15 and 20 of human p53 impair its apoptotic activity.

21 January 2018

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Steroid hormone receptors and their regulation by phosphorylation

21 January 2018

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Vaccinia virus gene H5R encodes a protein that is phosphorylated by the multisubstrate vaccinia virus B1R protein kinase.

21 January 2018

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7 January 2021

Comparative study of the p53-mdm2 and p53-MDMX interfaces

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7 January 2021

Inactivation of the p53-homologue p73 by the mdm2-oncoprotein

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7 January 2021

Protein kinase CK1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15

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7 January 2021

Expression of a new isoform of the tumor susceptibility TSG101 protein lacking a leucine zipper domain in Burkitt lymphoma cell lines

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7 January 2021

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7 January 2021

The vaccinia virus B1R gene product is a serine/threonine protein kinase

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7 January 2021

New developments in the multi-site phosphorylation and integration of stress signalling at p53

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7 January 2021

Vaccinia virus B1 kinase: phenotypic analysis of temperature-sensitive mutants and enzymatic characterization of recombinant proteins

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7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1203709

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10951572%20AND%20SRC:MED&resulttype=core&format=json

Dimensions Publication ID

9 November 2019

1013109521

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10951572%20AND%20SRC:MED&resulttype=core&format=json