p53 and Cell Cycle Proteins Participate in Spinal Motor Neuron Cell Death in ALS (Q34973926)

5 August 2017

title

p53 and Cell Cycle Proteins Participate in Spinal Motor Neuron Cell Death in ALS (English)

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amyotrophic lateral sclerosis

5 August 2017

main subject

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Srikanth Ranganathan

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5 August 2017

Robert Bowser

series ordinal

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5 August 2017

publication date

1 January 2010

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The open pathology journal

5 August 2017

published in

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5 August 2017

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5 August 2017

page(s)

11-22

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Ubiquitinated pathological lesions in frontotemporal lobar degeneration contain the TAR DNA-binding protein, TDP-43.

5 August 2017

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8 July 2018

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8 July 2018

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Adult motor neuron apoptosis is mediated by nitric oxide and Fas death receptor linked by DNA damage and p53 activation.

8 July 2018

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8 July 2018

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The extracellular matrix, p53 and estrogen compete to regulate cell-surface Fas/Apo-1 suicide receptor expression in proliferating embryonic cerebral cortical precursors, and reciprocally, Fas-ligand modifies estrogen control of cell-cycle proteins

8 July 2018

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Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis

8 July 2018

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Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

8 July 2018

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Direct coupling of the cell cycle and cell death machinery by E2F.

8 July 2018

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8 July 2018

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8 July 2018

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Role of the p53-homologue p73 in E2F1-induced apoptosis

8 July 2018

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Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis

8 July 2018

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Activity of the human cytochrome c1 promoter is modulated by E2F.

8 July 2018

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Neuronal death in amyotrophic lateral sclerosis is apoptosis: possible contribution of a programmed cell death mechanism

8 July 2018

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The involvement of p53 in dopamine-induced apoptosis of cerebellar granule neurons and leukemic cells overexpressing p53.

8 July 2018

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Cloning and characterization of a novel cellular protein, TDP-43, that binds to human immunodeficiency virus type 1 TAR DNA sequence motifs

8 July 2018

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Wild-type p53 can inhibit oncogene-mediated focus formation

8 July 2018

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The p53 proto-oncogene can act as a suppressor of transformation

8 July 2018

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Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

8 July 2018

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Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

8 July 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

8 July 2018

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Transcription factor p53 in degenerating spinal cords

8 July 2018

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Thalidomide and lenalidomide extend survival in a transgenic mouse model of amyotrophic lateral sclerosis.

26 October 2018

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Proteasome inhibition induces selective motor neuron death in organotypic slice cultures

26 October 2018

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Increased oxidative damage to DNA in an animal model of amyotrophic lateral sclerosis

26 October 2018

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Inhibition of the E2F-1/p53/Bax pathway by tauroursodeoxycholic acid in amyloid beta-peptide-induced apoptosis of PC12 cells

26 October 2018

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Cell cycle activation linked to neuronal cell death initiated by DNA damage

26 October 2018

1 reference

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Role and regulation of p53 in depolarization-induced neuronal death.

26 October 2018

1 reference

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p53 is present in synapses where it mediates mitochondrial dysfunction and synaptic degeneration in response to DNA damage, and oxidative and excitotoxic insults

26 October 2018

1 reference

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Proteasomal inhibition by misfolded mutant superoxide dismutase 1 induces selective motor neuron death in familial amyotrophic lateral sclerosis

26 October 2018

1 reference

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Motoneuron death triggered by a specific pathway downstream of Fas. potentiation by ALS-linked SOD1 mutations.

26 October 2018

1 reference

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DNA base-excision repair enzyme apurinic/apyrimidinic endonuclease/redox factor-1 is increased and competent in the brain and spinal cord of individuals with amyotrophic lateral sclerosis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092395

Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092395

Inhibition of 6-hydroxydopamine-induced p53 expression and survival of neuroblastoma cells following interaction with astrocytes.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092395

p53 is abnormally elevated and active in the CNS of patients with amyotrophic lateral sclerosis

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092395

Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092395

Delayed selective motor neuron death and fas antigen induction after spinal cord ischemia in rabbits

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092395

p53 and Bax activation in 6-hydroxydopamine-induced apoptosis in PC12 cells

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092395

Thymocyte apoptosis induced by p53-dependent and independent pathways.

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092395

Apaf-1 is a transcriptional target for E2F and p53

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3092395

Absence of p53: no effect in a transgenic mouse model of familial amyotrophic lateral sclerosis

9 December 2018

1 reference

12 December 2020

Induction and modulation of cerebellar granule neuron death by E2F-1

1 reference

12 December 2020

Genetic background alters the spectrum of tumors that develop in p53-deficient mice

1 reference

12 December 2020

Alteration of the Bcl-x/Bax ratio in a transgenic mouse model of amyotrophic lateral sclerosis: evidence for the implication of the p53 signaling pathway

1 reference

12 December 2020

Increased oxidative damage to DNA in ALS patients

1 reference

12 December 2020

Role of p53 in DNA strand break-induced apoptosis in organotypic slice culture from the mouse cerebellum

1 reference

12 December 2020

10.2174/1874375701004010011

Identifiers

DOI

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5 August 2017

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5 August 2017

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