In vivo administration of a JAK3 inhibitor to chronically siv infected rhesus macaques leads to NK cell depletion associated with transient modest increase in viral loads (Q34907640)

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English	In vivo administration of a JAK3 inhibitor to chronically siv infected rhesus macaques leads to NK cell depletion associated with transient modest increase in viral loads	scientific article

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PubMed publication ID

5 August 2017

In vivo administration of a JAK3 inhibitor to chronically siv infected rhesus macaques leads to NK cell depletion associated with transient modest increase in viral loads (English)

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Europe PubMed Central

PubMed publication ID

5 August 2017

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Aftab A. Ansari

7

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Aftab A Ansari

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5 August 2017

Kovit Pattanapanyasat

4

object named as

Kovit Pattanapanyasat

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5 August 2017

Francois Villinger

6

object named as

Francois Villinger

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5 August 2017

2

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Ann E Mayne

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5 August 2017

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Yoshiaki Takahashi

1

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5 August 2017

Ladawan Khowawisetsut

3

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5 August 2017

Dawn Little

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5 August 2017

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publication date

26 July 2013

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5 August 2017

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Europe PubMed Central

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5 August 2017

8

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5 August 2017

7

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Europe PubMed Central

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5 August 2017

e70992

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Europe PubMed Central

PubMed publication ID

5 August 2017

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Creative Commons Attribution 4.0 International

26 July 2013

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April 2022 Public Data File from Crossref

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0 references

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3-Amido pyrrolopyrazine JAK kinase inhibitors: development of a JAK3 vs JAK1 selective inhibitor and evaluation in cellular and in vivo models

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Role of transmitted Gag CTL polymorphisms in defining replicative capacity and early HIV-1 pathogenesis

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Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression

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Cytokine activation induces human memory-like NK cells

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NK cells regulate CD8+ T cell priming and dendritic cell migration during influenza A infection by IFN-γ and perforin-dependent mechanisms.

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The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses.

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IL-17-producing innate lymphoid cells are restricted to mucosal tissues and are depleted in SIV-infected macaques

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Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates

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JAK and STAT signaling molecules in immunoregulation and immune-mediated disease

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The JAK-STAT pathway at twenty

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The Jak/STAT pathway

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Biology and significance of the JAK/STAT signalling pathways

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Defining early human NK cell developmental stages in primary and secondary lymphoid tissues

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NK cells--from bench to clinic

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Natural killer cell activation enhances immune pathology and promotes chronic infection by limiting CD8+ T-cell immunity

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miR-150 regulates the development of NK and iNKT cells

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Natural killer cells act as rheostats modulating antiviral T cells

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NK cell development, homeostasis and function: parallels with CD8⁺ T cells

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Incorporation of innate immune effector mechanisms in the formulation of a vaccine against HIV-1.

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Development of thymic NK cells from double negative 1 thymocyte precursors

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Gut inflammation and indoleamine deoxygenase inhibit IL-17 production and promote cytotoxic potential in NKp44+ mucosal NK cells during SIV infection

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Unifying concepts of MHC-dependent natural killer cell education

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Regulation of NK cell repertoire and function in the liver

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Modulation of innate and adaptive immune responses by tofacitinib (CP-690,550).

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Innate or adaptive immunity? The example of natural killer cells

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Blocking of α4β7 Gut-Homing Integrin during Acute Infection Leads to Decreased Plasma and Gastrointestinal Tissue Viral Loads in Simian Immunodeficiency Virus-Infected Rhesus Macaques

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Innate Immune Natural Killer Cells and Their Role in HIV and SIV Infection

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Memory-like responses of natural killer cells

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Targeting early infection to prevent HIV-1 mucosal transmission.

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NK cells influence both innate and adaptive immune responses after mucosal immunization with antigen and mucosal adjuvant.

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Nfil3/E4bp4 is required for the development and maturation of NK cells in vivo

1 reference

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Regulation of human NK-cell cytokine and chemokine production by target cell recognition.

1 reference

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The safety and efficacy of a JAK inhibitor in patients with active rheumatoid arthritis: Results of a double-blind, placebo-controlled phase IIa trial of three dosage levels of CP-690,550 versus placebo

1 reference

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CD56bright natural killer (NK) cells: an important NK cell subset.

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8 July 2018

Natural killer cell tolerance licensing and other mechanisms.

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IL-15 trans-presentation promotes human NK cell development and differentiation in vivo

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8 July 2018

Human natural killer cells

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Noncytotoxic functions of NK cells: direct pathogen restriction and assistance to adaptive immunity

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In vivo natural killer cell depletion during primary simian immunodeficiency virus infection in rhesus monkeys

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The trafficking of natural killer cells

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No evidence for consistent virus-specific immunity in simian immunodeficiency virus-exposed, uninfected rhesus monkeys

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Evidence for discrete stages of human natural killer cell differentiation in vivo

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JAK3 inhibition, a viable new modality of immunosuppression for solid organ transplants

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Human natural killer cell deficiencies and susceptibility to infection

1 reference

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1 reference

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Synergistic effects of in vivo depletion of Ly-49A and Ly-49G2 natural killer cell subsets in the rejection of H2(b) bone marrow cell allografts.

1 reference

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In vivo natural killer cell activities revealed by natural killer cell-deficient mice

1 reference

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1 reference

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1 reference

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Age-associated decline in natural killer (NK) activity reflects primarily a defect in function of NK cells

1 reference

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Biology of natural killer cells

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In HIV-1 pathogenesis the die is cast during primary infection

1 reference

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1 reference

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1 reference

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21 January 2018

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1 reference

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21 January 2018

Natural killer cell memory

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21 January 2018

Licensing of natural killer cells by host major histocompatibility complex class I molecules

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1 reference

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21 January 2018

Severe herpesvirus infections in an adolescent without natural killer cells

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21 January 2018

Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques.

1 reference

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21 January 2018

Effects of JAK3 inhibition with CP-690,550 on immune cell populations and their functions in nonhuman primate recipients of kidney allografts

1 reference

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21 January 2018

The JAK3 inhibitor CP-690550 selectively reduces NK and CD8+ cell numbers in cynomolgus monkey blood following chronic oral dosing

1 reference

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21 January 2018

Quantitative analysis of the immunosuppressant CP-690,550 in whole blood by column-switching high-performance liquid chromatography and mass spectrometry detection

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21 January 2018

Combined use of the JAK3 inhibitor CP-690,550 with mycophenolate mofetil to prevent kidney allograft rejection in nonhuman primates

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21 January 2018

Phase 1 dose-escalation study of CP-690 550 in stable renal allograft recipients: preliminary findings of safety, tolerability, effects on lymphocyte subsets and pharmacokinetics

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21 January 2018

Phenotypically and functionally distinct subsets contribute to the expansion of CD56-/CD16+ natural killer cells in HIV infection.

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1 reference

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Sooty mangabeys and rhesus macaques exhibit significant divergent natural killer cell responses during both acute and chronic phases of SIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/23923040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulatory NK cells suppress antigen-specific T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23923040

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based on heuristic

inferred from PubMed ID database lookup

The JAM Test and its daughter P-JAM: simple tests of DNA fragmentation to measure cell death and stasis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23923040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Phase IIb dose-ranging study of the oral JAK inhibitor tofacitinib (CP-690,550) or adalimumab monotherapy versus placebo in patients with active rheumatoid arthritis with an inadequate response to disease-modifying antirheumatic drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/23923040

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based on heuristic

inferred from PubMed ID database lookup

In vivo regulation of experimental autoimmune encephalomyelitis by NK cells: alteration of primary adaptive responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/23923040

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0070992

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

2013PLoSO...870992T

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

5 August 2017

ResearchGate publication ID

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