ATPases as drug targets: learning from their structure (Q34810356)

4 August 2017

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title

ATPases as drug targets: learning from their structure (English)

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4 August 2017

Patrick Chène

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4 August 2017

publication date

1 September 2002

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Nature Reviews Drug Discovery

4 August 2017

published in

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

665-673

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The 90-kDa molecular chaperone family: structure, function, and clinical applications. A comprehensive review

4 August 2017

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Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase

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An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins

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The structures of HsIU and the ATP-dependent protease HsIU-HsIV

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A study into the effects of protein binding on nucleotide conformation

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Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

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The Amino-terminal Domain of Heat Shock Protein 90 (hsp90) That Binds Geldanamycin Is an ATP/ADP Switch Domain That Regulates hsp90 Conformation

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Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent

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Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone

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Hsp90 inhibitors as novel cancer chemotherapeutic agents

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Inhibition of branched-chain alpha-keto acid dehydrogenase kinase and Sln1 yeast histidine kinase by the antifungal antibiotic radicicol

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A structural pathway for activation of the kinesin motor ATPase.

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Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

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The crystal structure of DNA mismatch repair protein MutS binding to a G x T mismatch

21 January 2018

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The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter

21 January 2018

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Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter

21 January 2018

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Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing

21 January 2018

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DNA binding mediates conformational changes and metal ion coordination in the active site of PcrA helicase

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Structure and mechanism of the RuvB Holliday junction branch migration motor

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Atomic structure of the clamp loader small subunit from Pyrococcus furiosus

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Crystal structure of the hexamerization domain of N-ethylmaleimide-sensitive fusion protein

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Structure of the AAA ATPase p97

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Structure and function of Cdc6/Cdc18: implications for origin recognition and checkpoint control

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Crystal structure of T7 gene 4 ring helicase indicates a mechanism for sequential hydrolysis of nucleotides

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Structure of bovine mitochondrial F(1)-ATPase with nucleotide bound to all three catalytic sites: implications for the mechanism of rotary catalysis

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Structural and functional studies of MinD ATPase: implications for the molecular recognition of the bacterial cell division apparatus.

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Conformational changes in four regions of the Escherichia coli ArsA ATPase link ATP hydrolysis to ion translocation

21 January 2018

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The structure of crystalline profilin-beta-actin

21 January 2018

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Crystal structure of the cell division protein FtsA from Thermotoga maritima

21 January 2018

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In vivo function of Hsp90 is dependent on ATP binding and ATP hydrolysis

21 January 2018

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Dimerization of Escherichia coli DNA-gyrase B provides a structural mechanism for activating the ATPase catalytic center

21 January 2018

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Transformation of MutL by ATP binding and hydrolysis: a switch in DNA mismatch repair

21 January 2018

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21 January 2018

The Protein Data Bank

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21 January 2018

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Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis

21 January 2018

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Structure of Haemophilus influenzae HslU protein in crystals with one-dimensional disorder twinning

21 January 2018

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The Interaction of Coumarin Antibiotics with Fragments of the DNA Gyrase B Protein†

21 January 2018

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Structure of a new crystal form of human Hsp70 ATPase domain

21 January 2018

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Mode of action of GR122222X, a novel inhibitor of bacterial DNA gyrase.

21 January 2018

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31 March 2020

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD894

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4 August 2017

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