The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization. (Q34789134)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21127195%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

title

The tumor suppressor protein menin inhibits AKT activation by regulating its cellular localization (English)

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17 January 2020

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17 January 2020

Yan Wang

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17 January 2020

Atsushi Ozawa

1 reference

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17 January 2020

Shadia Zaman

1 reference

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17 January 2020

Nijaguna B Prasad

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17 January 2020

Settara C Chandrasekharappa

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17 January 2020

Stephen J Marx

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17 January 2020

language of work or name

English

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publication date

2 December 2010

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17 January 2020

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17 January 2020

volume

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17 January 2020

issue

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17 January 2020

page(s)

371-382

1 reference

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Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene

17 January 2020

cites work

1 reference

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Identification and distribution of a novel platelet-derived growth factor receptor beta variant: effect of retinoic acid and involvement in cell differentiation

8 July 2018

1 reference

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In search of tumor suppressing functions of menin

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Autocrine anti-apoptotic and proliferative effects of insulin in pancreatic beta-cells

8 July 2018

1 reference

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KLF6 degradation after apoptotic DNA damage.

8 July 2018

1 reference

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Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Emerging role of protein kinase B/Akt signaling in pancreatic beta-cell mass and function.

8 July 2018

1 reference

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Molecular genetics of multiple endocrine neoplasia types 1 and 2.

8 July 2018

1 reference

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Prenatal estrogen exposure differentially affects estrogen receptor-associated proteins in rat testis gonocytes

8 July 2018

1 reference

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Menin induces apoptosis in murine embryonic fibroblasts

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoter

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

The 32-kilodalton subunit of replication protein A interacts with menin, the product of the MEN1 tumor suppressor gene

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Menin's interaction with glial fibrillary acidic protein and vimentin suggests a role for the intermediate filament network in regulating menin activity

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

The phosphatidylinositol 3-Kinase AKT pathway in human cancer

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Transforming ability of MEN2A-RET requires activation of the phosphatidylinositol 3-kinase/AKT signaling pathway.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Nuclear/cytoplasmic localization of the multiple endocrine neoplasia type 1 gene product, menin.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

A simplified system for generating recombinant adenoviruses

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Menin, the product of the MEN1 gene, is a nuclear protein

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Positional cloning of the gene for multiple endocrine neoplasia-type 1

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Nuclear-cytoplasmic shuttling of menin regulates nuclear translocation of {beta}-catenin.

8 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha

26 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3076053

Enhanced protein kinase B/Akt signalling in pituitary tumours

26 October 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21127195

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/21127195

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1158/0008-5472.CAN-10-3221

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21127195%20AND%20SRC:MED&resulttype=core&format=json

17 January 2020

1 reference

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17 January 2020

PubMed publication ID

21127195

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21127195%20AND%20SRC:MED&resulttype=core&format=json