The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy (Q34763495)

4 August 2017

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title

The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy (English)

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4 August 2017

Isabel M Chu

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4 August 2017

Ludger Hengst

series ordinal

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4 August 2017

Joyce M Slingerland

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4 August 2017

language of work or name

English

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publication date

1 April 2008

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4 August 2017

published in

Nature Reviews Cancer

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

253-267

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CDK inhibitors: positive and negative regulators of G1-phase progression

4 August 2017

cites work

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Targets of cyclin-dependent protein kinases.

31 March 2020

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Differential modification of p27Kip1 controls its cyclin D-cdk4 inhibitory activity

31 March 2020

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Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases

31 March 2020

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Translational control of p27Kip1 accumulation during the cell cycle

31 March 2020

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Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression

31 March 2020

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Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors?

31 March 2020

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AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1

31 March 2020

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Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

31 March 2020

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Identification of a tumour suppressor network opposing nuclear Akt function

31 March 2020

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Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity

31 March 2020

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Increased hepatic Forkhead Box M1B (FoxM1B) levels in old-aged mice stimulated liver regeneration through diminished p27Kip1 protein levels and increased Cdc25B expression

31 March 2020

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Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c

31 March 2020

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Analysis of p27(Kip1) expression in insulinomas developed in pancreatic beta-cell specific Men1 mutant mice.

31 March 2020

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Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans

31 March 2020

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Mutation analysis of aryl hydrocarbon receptor interacting protein (AIP) gene in colorectal, breast, and prostate cancers

31 March 2020

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Repression of transcription of the p27(Kip1) cyclin-dependent kinase inhibitor gene by c-Myc.

31 March 2020

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Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

31 March 2020

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Myc targets Cks1 to provoke the suppression of p27Kip1, proliferation and lymphomagenesis

31 March 2020

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Activation of p27Kip1 Expression by E2F1. A negative feedback mechanism.

31 March 2020

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Sp1 and NF-Y synergistically mediate the effect of vitamin D(3) in the p27(Kip1) gene promoter that lacks vitamin D response elements

31 March 2020

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Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

31 March 2020

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Vitamin D3 receptor/Sp1 complex is required for the induction of p27Kip1 expression by vitamin D3.

31 March 2020

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Repression of p27kip1 synthesis by platelet-derived growth factor in BALB/c 3T3 cells

31 March 2020

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Enhanced ribosomal association of p27(Kip1) mRNA is a mechanism contributing to accumulation during growth arrest.

31 March 2020

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Cell cycle-dependent translation of p27 involves a responsive element in its 5'-UTR that overlaps with a uORF

31 March 2020

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Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation

31 March 2020

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ELAV/Hu proteins inhibit p27 translation via an IRES element in the p27 5'UTR.

31 March 2020

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Impaired control of IRES-mediated translation in X-linked dyskeratosis congenita

31 March 2020

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Polypyrimidine tract-binding protein enhances the internal ribosomal entry site-dependent translation of p27Kip1 mRNA and modulates transition from G1 to S phase

31 March 2020

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A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.

31 March 2020

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Overexpression of the embryonic-lethal abnormal vision-like protein HuR in ovarian carcinoma is a prognostic factor and is associated with increased cyclooxygenase 2 expression

31 March 2020

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Role of the RNA-binding protein HuR in colon carcinogenesis

31 March 2020

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Rho activity can alter the translation of p27 mRNA and is important for RasV12-induced transformation in a manner dependent on p27 status.

31 March 2020

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Inhibition of Cdk4 activity enhances translation of p27kip1 in quiescent Rb-negative cells

31 March 2020

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Diverse ways to control p27Kip1 function: miRNAs come into play

31 March 2020

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RNA-binding protein Dnd1 inhibits microRNA access to target mRNA

31 March 2020

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miR-221 and miR-222 expression affects the proliferation potential of human prostate carcinoma cell lines by targeting p27Kip1.

31 March 2020

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A microRNA expression signature of human solid tumors defines cancer gene targets

31 March 2020

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MicroRNAs (miR)-221 and miR-222, both overexpressed in human thyroid papillary carcinomas, regulate p27Kip1 protein levels and cell cycle

31 March 2020

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A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia

31 March 2020

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Ubiquitin ligases: cell-cycle control and cancer

31 March 2020

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Deregulated degradation of the cdk inhibitor p27 and malignant transformation.

31 March 2020

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Regulation of p27 degradation and S-phase progression by Ro52 RING finger protein

31 March 2020

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Mechanisms of cyclin-dependent kinase regulation: structures of Cdks, their cyclin activators, and Cip and INK4 inhibitors

31 March 2020

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p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2

31 March 2020

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Crystal structure of the p27Kip1 cyclin-dependent-kinase inhibitor bound to the cyclin A-Cdk2 complex

31 March 2020

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A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase

31 March 2020

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Cul4A and DDB1 associate with Skp2 to target p27Kip1 for proteolysis involving the COP9 signalosome

31 March 2020

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Degradation of the cyclin-dependent-kinase inhibitor p27Kip1 is instigated by Jab1

31 March 2020

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A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression

31 March 2020

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The cyclin-dependent kinase inhibitor p27Kip1 is stabilized in G(0) by Mirk/dyrk1B kinase

31 March 2020

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p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis

31 March 2020

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Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

31 March 2020

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CRM1/Ran-mediated nuclear export of p27(Kip1) involves a nuclear export signal and links p27 export and proteolysis

31 March 2020

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A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression

31 March 2020

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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

31 March 2020

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C-terminal phosphorylation controls the stability and function of p27kip1

31 March 2020

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Role of serine 10 phosphorylation in p27 stabilization revealed by analysis of p27 knock-in mice harboring a serine 10 mutation

31 March 2020

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c-Src and cooperating partners in human cancer

31 March 2020

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HER-2/neu as a predictive marker of response to breast cancer therapy

31 March 2020

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Decreased immunoreactivity for p27 protein in patients with early-stage breast carcinoma is correlated with HER-2/neu overexpression and with benefit from one course of perioperative chemotherapy in patients with negative lymph node status: results

31 March 2020

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Correlation of p27 protein expression with HER-2/neu expression in breast cancer.

31 March 2020

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Constitutive MEK/MAPK activation leads to p27(Kip1) deregulation and antiestrogen resistance in human breast cancer cells

31 March 2020

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Oncogenic signals of HER-2/neu in regulating the stability of the cyclin-dependent kinase inhibitor p27.

31 March 2020

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P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells.

31 March 2020

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Reversible G(1) arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27(KIP1) independent of MAPK activity

31 March 2020

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Clinical significance of cyclin-dependent kinase inhibitor p27Kip1 expression and proliferation in non-Hodgkin's lymphoma: independent prognostic value of p27Kip1

31 March 2020

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The prognostic significance of altered cyclin-dependent kinase inhibitors in human cancer

31 March 2020

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BCR-ABL induces the expression of Skp2 through the PI3K pathway to promote p27Kip1 degradation and proliferation of chronic myelogenous leukemia cells

31 March 2020

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BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

31 March 2020

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The phosphatidylinositol 3-Kinase AKT pathway in human cancer

31 March 2020

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Inactivation of PTEN is associated with a low p27Kip1 protein expression in breast carcinoma

31 March 2020

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Role of the F-box protein Skp2 in lymphomagenesis

31 March 2020

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Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas

31 March 2020

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The prognostic impact of the ubiquitin ligase subunits Skp2 and Cks1 in colorectal carcinoma

31 March 2020

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Oncogenic role of the ubiquitin ligase subunit Skp2 in human breast cancer

31 March 2020

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Skp2 and Jab1 expression are associated with inverse expression of p27(KIP1) and poor prognosis in oral squamous cell carcinomas

31 March 2020

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Skp2 is oncogenic and overexpressed in human cancers

31 March 2020

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A novel target gene, SKP2, within the 5p13 amplicon that is frequently detected in small cell lung cancers.

31 March 2020

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Skp2-mediated degradation of p27 regulates progression into mitosis

31 March 2020

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Skp2-dependent degradation of p27kip1 is essential for cell cycle progression

31 March 2020

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Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer

31 March 2020

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Expression of cell-cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients

31 March 2020

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Minimal requirements for the nuclear localization of p27(Kip1), a cyclin-dependent kinase inhibitor

31 March 2020

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New functional activities for the p21 family of CDK inhibitors

31 March 2020

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The p21(Cip1) and p27(Kip1) CDK 'inhibitors' are essential activators of cyclin D-dependent kinases in murine fibroblasts

31 March 2020

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PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest

31 March 2020

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Phosphorylation of p27Kip1 at Thr-157 interferes with its association with importin alpha during G1 and prevents nuclear re-entry

31 March 2020

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14-3-3 suppresses the nuclear localization of threonine 157-phosphorylated p27(Kip1)

31 March 2020

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Akt-dependent phosphorylation of p27Kip1 promotes binding to 14-3-3 and cytoplasmic localization

31 March 2020

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Phosphorylation of p27Kip1 at Threonine 198 by p90 Ribosomal Protein S6 Kinases Promotes Its Binding to 14-3-3 and Cytoplasmic Localization

31 March 2020

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Tyrosine phosphorylation modulates binding preference to cyclin-dependent kinases and subcellular localization of p27Kip1 in the acute promyelocytic leukemia cell line NB4.

31 March 2020

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p21-containing cyclin kinases exist in both active and inactive states

31 March 2020

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Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration

31 March 2020

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Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)

31 March 2020

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Disruption of TGF-beta growth inhibition by oncogenic ras is linked to p27Kip1 mislocalization

31 March 2020

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Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer

31 March 2020

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PKB/Akt mediates cell-cycle progression by phosphorylation of p27(Kip1) at threonine 157 and modulation of its cellular localization

31 March 2020

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Understanding p27(kip1) deregulation in cancer: down-regulation or mislocalization

31 March 2020

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Subcellular Localization and Protein Levels of Cyclin-Dependent Kinase Inhibitor p27 Independently Predict for Survival in Epithelial Ovarian Cancer

31 March 2020

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p27(Kip1)-stathmin interaction influences sarcoma cell migration and invasion

31 March 2020

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Novel p27(kip1) C-terminal scatter domain mediates Rac-dependent cell migration independent of cell cycle arrest functions

31 March 2020

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Reduction of cytosolic p27(Kip1) inhibits cancer cell motility, survival, and tumorigenicity

31 March 2020

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Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma

31 March 2020

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Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype

31 March 2020

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p27/kip1 expression in normal epithelium, benign and neoplastic breast lesions

31 March 2020

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Immunohistochemical analysis of Ki-67, p53, p21, and p27 in benign and malignant apocrine lesions of the breast: its correlation to histologic findings in 43 cases

31 March 2020

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Expression of p21Waf1, p27Kip1 and cyclin D1 proteins in breast ductal carcinoma in situ: Relation with clinicopathologic characteristics and with p53 expression and estrogen receptor status

31 March 2020

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Reduced expression of p27Kip1 protein is associated with poor clinical outcome of breast cancer patients treated with systemic chemotherapy and is linked to cell proliferation and differentiation.

31 March 2020

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Loss of E-cadherin and p27 expression is associated with head and neck squamous tumorigenesis

31 March 2020

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Clinical relevance of expression of the CIP/KIP cell-cycle inhibitors p21 and p27 in laryngeal cancer

31 March 2020

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Prognostic value of cell cycle proteins p27(kip1) and MIB-1, and the cell adhesion protein CD44s in surgically treated patients with prostate cancer

31 March 2020

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Distinct altered patterns of p27KIP1 gene expression in benign prostatic hyperplasia and prostatic carcinoma

31 March 2020

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Implication of malignancy and prognosis of p27(kip1), Cyclin E, and Cdk2 expression in epithelial ovarian tumors

31 March 2020

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The combined evaluation of p27Kip1 and Ki-67 expression provides independent information on overall survival of ovarian carcinoma patients

31 March 2020

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The cyclin-dependent kinase inhibitor p27 as a prognostic factor in advanced non-small cell lung cancer: its immunohistochemical evaluation using biopsy specimens

31 March 2020

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Reduced expression of cell-cycle regulator p27(Kip1) correlates with a shortened survival in non-small cell lung cancer

31 March 2020

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High cyclin E and low p27/Kip1 expressions are potentially poor prognostic factors in lung adenocarcinoma patients

31 March 2020

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Prognostic significance of p27KIP1 expression in resected non-small cell lung cancers: analysis in combination with expressions of p16INK4A, pRB, and p53

31 March 2020

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Relationship between postoperative recurrence and expression of cyclin E, p27, and Ki-67 in non-small cell lung cancer without lymph node metastases

31 March 2020

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Epidermal growth factor receptor in non-small-cell lung carcinomas: correlation between gene copy number and protein expression and impact on prognosis.

31 March 2020

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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

31 March 2020

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Positive correlation between p27Kip1 expression and progression of human esophageal squamous cell carcinoma

31 March 2020

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Expression of protein p27 is associated with progression and prognosis in laryngeal cancer

31 March 2020

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Prognostic value of p27(Kip1) and CyclinD1 expression in esophageal cancer

31 March 2020

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Low p27 expression correlates with poor prognosis for patients with oral tongue squamous cell carcinoma

31 March 2020

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Expression of p27 is associated with Bax expression and spontaneous apoptosis in oral and oropharyngeal carcinoma

31 March 2020

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Prognostic significance of p27 expression in carcinoma of the oral cavity and oropharynx

31 March 2020

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Loss of p27(KIP1) expression predicts poor prognosis in patients with esophageal squamous cell carcinoma

31 March 2020

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Significance of the expression of p27Kip1 in esophageal squamous cell carcinomas

31 March 2020

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Cyclin-dependent kinase inhibitor p27 is related to cell proliferation and prognosis in laryngeal squamous cell carcinomas

31 March 2020

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Prognostic role of p27(Kip1) expression in oral squamous cell carcinoma in Taiwan.

31 March 2020

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Prognostic significance of G1 cell-cycle inhibitors in early laryngeal cancer

31 March 2020

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Prognostic significance of expression patterns of c-erbB-2, p53, p16INK4A, p27KIP1, cyclin D1 and epidermal growth factor receptor in oesophageal adenocarcinoma: a tissue microarray study

31 March 2020

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Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas.

31 March 2020

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Absence of the cell cycle inhibitor p27Kip1 protein predicts poor outcome in patients with stage I-III colorectal cancer

31 March 2020

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Prognostic significance of p27(Kip1) expression in colorectal cancer: a clinico-pathological characterization

31 March 2020

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Prognostic significance of p27(kip1) protein expression and spontaneous apoptosis in patients with colorectal adenocarcinomas

31 March 2020

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The prognostic value of invariant chain (Ii) and Her-2/neu expression in curatively resected colorectal cancer

31 March 2020

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Determination of molecular marker expression can predict clinical outcome in colon carcinomas.

31 March 2020

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Prognostic significance of p27(kip-1) expression in colorectal adenocarcinomas is associated with tumor stage

31 March 2020

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Thymidylate synthase expression, p53, bcl-2, Ki-67 and p27 in colorectal cancer: relationships with tumor recurrence and survival

31 March 2020

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Prognostic significance of DCC and p27Kip1 in colorectal cancer

31 March 2020

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Cytoplasmic expression of p27(kip1) is associated with a favourable prognosis in colorectal cancer patients.

31 March 2020

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Loss of p27 expression and microsatellite instability in sporadic colorectal cancer.

31 March 2020

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Prognostic value of p27, p53, and vascular endothelial growth factor in Dukes A and B colon cancer patients undergoing potentially curative surgery

31 March 2020

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Association of p27Kip1 levels with recurrence and survival in patients with stage C prostate carcinoma

31 March 2020

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Preoperative p27 status is an independent predictor of prostate specific antigen failure following radical prostatectomy

31 March 2020

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Biological correlates of p27 compartmental expression in prostate cancer

31 March 2020

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Predicting biochemical recurrence after radical prostatectomy for patients with organ-confined disease using p27 expression

31 March 2020

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Expression of the cell cycle inhibitor p27KIP1 is a new prognostic marker associated with survival in epithelial ovarian tumors

31 March 2020

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Cyclin-dependent kinase inhibitors CIP1 (p21) and KIP1 (p27) in ovarian cancer

31 March 2020

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Expression of p27kip1 in breast cancer and its prognostic significance

31 March 2020

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Cyclin-dependent kinase inhibitor p27Kip1 expression and interaction with other cell cycle-associated proteins in mammary carcinoma

31 March 2020

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p27kip1 expression in breast carcinomas: An immunohistochemical study on 512 patients with long-term follow-up

31 March 2020

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p27 expression correlates with short-term, but not with long-term prognosis in breast cancer

31 March 2020

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Prognostic implication of cyclin E expression and its relationship with cyclin D1 and p27Kip1 expression on tissue microarrays of node negative breast cancer

31 March 2020

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p27(Kip1) and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy

31 March 2020

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Prognostic role of p27Kip1 and apoptosis in human breast cancer

31 March 2020

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Prognostic impact of cyclin-dependent kinase inhibitor p27kip1 in node-positive breast cancer

31 March 2020

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Germline BRCA1/2 mutations and p27(Kip1) protein levels independently predict outcome after breast cancer.

31 March 2020

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Expression of cell-cycle regulator p27 is correlated to the prognosis and ER expression in breast carcinoma patients

31 March 2020

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High p27Kip1 Expression Predicts Superior Relapse-Free and Overall Survival for Premenopausal Women With Early-Stage Breast Cancer Receiving Adjuvant Treatment With Tamoxifen Plus Goserelin

31 March 2020

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The prognostic implication of the basal-like (cyclin E high/p27 low/p53+/glomeruloid-microvascular-proliferation+) phenotype of BRCA1-related breast cancer

31 March 2020

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Elevated levels of p27, p21 and cyclin D1 correlate with positive oestrogen and progesterone receptor status in node-negative breast carcinoma patients

31 March 2020

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Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2.

31 March 2020

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Steroid hormone receptors in breast cancer management

31 March 2020

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Expression of p27 and p53 in cervical squamous cell carcinoma patients treated with radiotherapy alone: radiotherapeutic effect and prognosis

31 March 2020

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Down-regulation of p21WAF1/CIP1 or p27Kip1 abrogates antiestrogen-mediated cell cycle arrest in human breast cancer cells

31 March 2020

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ErbB2 potentiates breast tumor proliferation through modulation of p27(Kip1)-Cdk2 complex formation: receptor overexpression does not determine growth dependency

31 March 2020

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Prognostic and predictive factors for breast cancer: translating technology to oncology

31 March 2020

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Gene expression profiling of breast cancer: a new tumor marker

31 March 2020

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Expression profiling of colorectal carcinomas using tissue microarrays: cell cycle regulatory proteins p21, p27, and p53 as immunohistochemical prognostic markers in univariate and multivariate analysis

31 March 2020

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Relationship between levels of Skp2 and P27 in breast carcinomas and possible role of Skp2 as targeted therapy

31 March 2020

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Pirh2 promotes ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27Kip1.

31 March 2020

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Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRC2347

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Dimensions Publication ID

4 August 2017

1046912140

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