Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling (Q34701183)

4 August 2017

title

Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling (English)

1 reference

4 August 2017

1 reference

Maarten van Dinther

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4 August 2017

Juan Zhang

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4 August 2017

Stella E Weidauer

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4 August 2017

Verena Boschert

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4 August 2017

Eva-Maria Muth

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4 August 2017

Achim Knappik

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4 August 2017

David J J de Gorter

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4 August 2017

Puck B van Kasteren

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4 August 2017

Christian Frisch

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4 August 2017

Thomas D Mueller

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4 August 2017

Peter ten Dijke

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4 August 2017

language of work or name

English

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publication date

29 April 2013

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4 August 2017

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4 August 2017

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4 August 2017

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4 August 2017

page(s)

e62295

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Creative Commons Attribution 4.0 International

4 August 2017

start time

29 April 2013

1 reference

April 2022 Public Data File from Crossref

copyrighted

0 references

describes a project that uses

ImageQuant

object named as

ImageQuant TL

2 references

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3639248/fullTextXML

inferred from PubMed Central ID database lookup

CZ Software Mentions: A large dataset of software mentions in the biomedical literature

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7 July 2018

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7 July 2018

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7 July 2018

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Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

7 July 2018

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Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

7 July 2018

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Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6

7 July 2018

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LRP6 is internalized by Dkk1 to suppress its phosphorylation in the lipid raft and is recycled for reuse

7 July 2018

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The FOP metamorphogene encodes a novel type I receptor that dysregulates BMP signaling

7 July 2018

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Characterization of the Structural Features and Interactions of Sclerostin: MOLECULAR INSIGHT INTO A KEY REGULATOR OF Wnt-MEDIATED BONE FORMATION

7 July 2018

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NMR structure of the Wnt modulator protein Sclerostin

7 July 2018

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Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis

7 July 2018

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Wnt3a and Dkk1 regulate distinct internalization pathways of LRP6 to tune the activation of beta-catenin signaling

7 July 2018

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The human combinatorial antibody library HuCAL GOLD combines diversification of all six CDRs according to the natural immune system with a novel display method for efficient selection of high-affinity antibodies.

7 July 2018

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Wnt but not BMP signaling is involved in the inhibitory action of sclerostin on BMP-stimulated bone formation

7 July 2018

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Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

7 July 2018

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SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor

7 July 2018

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7 July 2018

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7 July 2018

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Identification of the disease-causing gene in sclerosteosis--discovery of a novel bone anabolic target?

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)

7 July 2018

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Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein

7 July 2018

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An LDL-receptor-related protein mediates Wnt signalling in mice

7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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7 July 2018

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

7 July 2018

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https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0062295

Inhibition of sclerostin by monoclonal antibody enhances bone healing and improves bone density and strength of nonfractured bones

21 January 2018

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12 December 2020

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Inhibition of sclerostin by systemic treatment with sclerostin antibody enhances healing of proximal tibial defects in ovariectomized rats

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PubMed

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12 December 2020

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PubMed

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12 December 2020

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Identifiers

DOI

10.1371/JOURNAL.PONE.0062295

1 reference

4 August 2017

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1 reference

4 August 2017

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