Bone overgrowth-associated mutations in the LRP4 gene impair sclerostin facilitator function (Q24299076)

negative regulation of canonical Wnt signaling pathway

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

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Eveline Boudin

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Wim Van Hul

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Olivier Leupin

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Elke Piters

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Christine Halleux

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Shouih Hu

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Ina Kramer

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Frederic Morvan

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Tewis Bouwmeester

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Markus Schirle

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Manuel Bueno-Lozano

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Feliciano J Ramos Fuentes

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Peter H Itin

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Fenna de Freitas

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Karen Jennes

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Nadine Charara

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Hilmar Ebersbach

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Sabine Geisse

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Chris X Lu

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Andreas Bauer

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Michaela Kneissel

Journal of Biological Chemistry

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language of work or name

English

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publication date

3 June 2011

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published in

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volume

286

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issue

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page(s)

19489-500

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cites work

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Osteocyte control of bone formation via sclerostin, a novel BMP antagonist

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Identification of a 52 kb deletion downstream of the SOST gene in patients with van Buchem disease

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19 March 2017

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Bone density ligand, Sclerostin, directly interacts with LRP5 but not LRP5G171V to modulate Wnt activity

19 March 2017

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19 March 2017

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Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation

19 March 2017

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A 52-kb deletion in the SOST-MEOX1 intergenic region on 17q12-q21 is associated with van Buchem disease in the Dutch population

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Mutations in the gene encoding the low-density lipoprotein receptor LRP4 cause abnormal limb development in the mouse

19 March 2017

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Lrp4, a novel receptor for Dickkopf 1 and sclerostin, is expressed by osteoblasts and regulates bone growth and turnover in vivo

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Genomic deletion of a long-range bone enhancer misregulates sclerostin in Van Buchem disease

27 September 2017

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27 September 2017

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27 September 2017

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27 September 2017

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Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength

30 May 2018

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Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling

21 January 2018

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Identification of a doublet missense substitution in the bovine LRP4 gene as a candidate causal mutation for syndactyly in Holstein cattle

21 January 2018

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Agrin is highly expressed by chondrocytes and is required for normal growth.

21 January 2018

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21 January 2018

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Defective splicing of Megf7/Lrp4, a regulator of distal limb development, in autosomal recessive mulefoot disease

21 January 2018

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29 November 2018

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1074/JBC.M110.190330

1 reference

1 reference

1 reference

PubMed publication ID

21471202

1 reference