Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein (Q34650215)

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English	Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

Prophylaxis and treatment of Alzheimer's disease by delivery of an adeno-associated virus encoding a monoclonal antibody targeting the amyloid Beta protein (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

Alzheimer's disease

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1 reference

based on heuristic

inferred from title

monoclonal antibody

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based on heuristic

inferred from title

author name string

Masaru Shimada

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

Shinya Abe

2

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Europe PubMed Central

PubMed publication ID

3 August 2017

Toru Takahashi

3

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Europe PubMed Central

PubMed publication ID

3 August 2017

Kazumasa Shiozaki

4

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Europe PubMed Central

PubMed publication ID

3 August 2017

Mitsue Okuda

5

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Europe PubMed Central

PubMed publication ID

3 August 2017

Hiroaki Mizukami

6

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Europe PubMed Central

PubMed publication ID

3 August 2017

Dennis M Klinman

7

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Europe PubMed Central

PubMed publication ID

3 August 2017

Keiya Ozawa

8

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Europe PubMed Central

PubMed publication ID

3 August 2017

Kenji Okuda

9

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Europe PubMed Central

PubMed publication ID

3 August 2017

language of work or name

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publication date

28 March 2013

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

PubMed publication ID

3 August 2017

8

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Europe PubMed Central

PubMed publication ID

3 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

e57606

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Europe PubMed Central

PubMed publication ID

3 August 2017

copyright license

Creative Commons Attribution 4.0 International

28 March 2013

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April 2022 Public Data File from Crossref

copyright status

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Immunogenic comparison of chimeric adenovirus 5/35 vector carrying optimized human immunodeficiency virus clade C genes and various promoters

1 reference

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7 July 2018

Adeno-associated virus-mediated brain delivery of 5-lipoxygenase modulates the AD-like phenotype of APP mice

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Anti-Amyloid-β Single-Chain Antibody Brain Delivery Via AAV Reduces Amyloid Load But May Increase Cerebral Hemorrhages in an Alzheimer's Disease Mouse Model

1 reference

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7 July 2018

APP processing in Alzheimer's disease

1 reference

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Abeta-directed single-chain antibody delivery via a serotype-1 AAV vector improves learning behavior and pathology in Alzheimer's disease mice

1 reference

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Should the ApoE genotype be a covariate for clinical trials in Alzheimer disease?

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A single ascending dose study of bapineuzumab in patients with Alzheimer disease

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An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42

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A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease

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7 July 2018

Generating differentially targeted amyloid-beta specific intrabodies as a passive vaccination strategy for Alzheimer's disease

1 reference

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7 July 2018

Expression of neprilysin in skeletal muscle reduces amyloid burden in a transgenic mouse model of Alzheimer disease

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7 July 2018

Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial

1 reference

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7 July 2018

Deglycosylated anti-Abeta antibody dose-response effects on pathology and memory in APP transgenic mice

1 reference

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7 July 2018

Amyloid-beta E22Delta variant induces synaptic alteration in mouse hippocampal slices

1 reference

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7 July 2018

Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers

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7 July 2018

Transcutaneous beta-amyloid immunization reduces cerebral beta-amyloid deposits without T cell infiltration and microhemorrhage

1 reference

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7 July 2018

Nonviral Abeta DNA vaccine therapy against Alzheimer's disease: long-term effects and safety

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7 July 2018

Anti-Abeta single-chain antibody delivery via adeno-associated virus for treatment of Alzheimer's disease

1 reference

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Large-scale production of recombinant viruses by use of a large culture vessel with active gassing

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Tetrazolium dyes as tools in cell biology: new insights into their cellular reduction.

1 reference

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7 July 2018

The F(ab)'2 fragment of an Abeta-specific monoclonal antibody reduces Abeta deposits in the brain

1 reference

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7 July 2018

Stable antibody expression at therapeutic levels using the 2A peptide

1 reference

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Cerebral amyloid angiopathy and thrombolysis-related intracerebral haemorrhage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610755

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Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610755

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In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610755

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

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A novel recombinant adeno-associated virus vaccine induces a long-term humoral immune response to human immunodeficiency virus

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

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Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610755

7 July 2018

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

1 reference

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Neurotrophic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides

1 reference

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Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease

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26 October 2018

CERE-110, an adeno-associated virus-based gene delivery vector expressing human nerve growth factor for the treatment of Alzheimer's disease.

1 reference

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Adeno-associated viral (AAV) serotype 5 vector mediated gene delivery of endothelin-converting enzyme reduces Abeta deposits in APP + PS1 transgenic mice

1 reference

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Immunotherapy reduces vascular amyloid-beta in PDAPP mice.

1 reference

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Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model

1 reference

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1 reference

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26 October 2018

Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.

1 reference

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26 October 2018

Abeta species removal after abeta42 immunization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3610755

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Evidence of multiyear factor IX expression by AAV-mediated gene transfer to skeletal muscle in an individual with severe hemophilia B.

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26 October 2018

Virus and virus-like particle-based immunogens for Alzheimer's disease induce antibody responses against amyloid-beta without concomitant T cell responses

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26 October 2018

Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

1 reference

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26 October 2018

Development of a safe oral Abeta vaccine using recombinant adeno-associated virus vector for Alzheimer's disease.

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26 October 2018

Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer's disease

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26 October 2018

Adeno-associated viral vector-mediated ApoE expression in Alzheimer's disease mice: low CNS immune response, long-term expression, and astrocyte specificity

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26 October 2018

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

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26 October 2018

Cerebral hemorrhage after passive anti-Abeta immunotherapy

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Nerve inflammation halts trial for Alzheimer's drug.

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A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

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Occurrence of the diffuse amyloid beta-protein (Abeta) deposits with numerous Abeta-containing glial cells in the cerebral cortex of patients with Alzheimer's disease

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26 October 2018

Identifiers

10.1371/JOURNAL.PONE.0057606

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Europe PubMed Central

PubMed publication ID

3 August 2017

2013PLoSO...857606S

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PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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