Genetic mechanisms of hepatocarcinogenesis (Q34611410)

3 August 2017

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title

Genetic mechanisms of hepatocarcinogenesis (English)

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3 August 2017

Mark A Feitelson

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3 August 2017

Bill Sun

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3 August 2017

N Lale Satiroglu Tufan

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3 August 2017

Jie Liu

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3 August 2017

Jingbo Pan

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3 August 2017

Zhaorui Lian

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3 August 2017

language of work or name

English

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publication date

1 April 2002

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3 August 2017

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3 August 2017

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3 August 2017

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3 August 2017

page(s)

2593-2604

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Allelic imbalance of insulin-like growth factor II gene expression in cancerous and precancerous lesions of the liver

3 August 2017

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Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.

21 January 2018

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A new retinoic acid receptor identified from a hepatocellular carcinoma

21 January 2018

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Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade

21 January 2018

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Absence of p53 gene mutations in hepatocarcinomas from a Mediterranean area of Spain. A study of 129 archival tumour samples

21 January 2018

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Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa

21 January 2018

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Low frequency of p53 mutations observed in a diverse collection of primary hepatocellular carcinomas

21 January 2018

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Complete regression of established murine hepatocellular carcinoma by in vivo tumor necrosis factor alpha gene transfer

21 January 2018

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Maternal transmission of hepatitis B virus in childhood hepatocellular carcinoma

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Loss of heterozygosity in liver tumours

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Mechanisms and consequences of activation of protein kinase B/Akt

21 January 2018

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Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

21 January 2018

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Genomic imprinting: implications for human disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Hepatitis C virus NS5A protein modulates cell cycle regulatory genes and promotes cell growth

21 January 2018

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Identification of human cancer-related genes by naturally occurring Hepatitis B Virus DNA tagging

21 January 2018

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Hepatic polyploidy and liver growth control.

21 January 2018

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Oxidative mechanisms in carcinogenesis

21 January 2018

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Expression of X protein and hepatitis B virus replication in chronic hepatitis

21 January 2018

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Hepatitis C virus core protein activates the MAPK/ERK cascade synergistically with tumor promoter TPA, but not with epidermal growth factor or transforming growth factor alpha

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Evidence for increased in vitro recombination with insertion of human hepatitis B virus DNA

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Beta-catenin mutations are associated with a subset of low-stage hepatocellular carcinoma negative for hepatitis B virus and with favorable prognosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Mutational hot spot in the p53 gene in human hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Complex formation of the nonstructural protein 3 of hepatitis C virus with the p53 tumor suppressor

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Aberrant DNA methylation on chromosome 16 is an early event in hepatocarcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

DNA hypermethylation at the D17S5 locus and reduced HIC-1 mRNA expression are associated with hepatocarcinogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

PTEN/MMAC1 mutations in hepatocellular carcinomas: somatic inactivation of both alleles in tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

X-gene product of hepatitis B virus induces apoptosis in liver cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Activation of Src Family Kinases by Hepatitis B Virus HBx Protein and Coupled Signaling to Ras

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

DNA copy number losses in human neoplasms

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Genetic changes and histopathological grades in human hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Localization of a target region of allelic loss to a 1-cM interval on chromosome 16p.13.13 in hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Accumulation of genetic changes during development and progression of hepatocellular carcinoma: Loss of heterozygosity on chromosome arm Ip occurs at an early stage of hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

HBx protein of hepatitis B virus activates Jak1-STAT signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Frequent allelic loss on chromosome 9 in hepatocellular carcinoma.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Accumulation of genetic alterations in a human hepatoma cell line transfected with hepatitis B virus

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Inactivation of SSI-1, a JAK/STAT inhibitor, in human hepatocellular carcinomas, as revealed by two-dimensional electrophoresis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Frequent genomic imbalances suggest commonly altered tumour genes in human hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Hepatocellular carcinoma: clinicopathological aspects

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Hepatitis B virus-X protein upregulates the expression of p21waf1/cip1 and prolongs G1-->S transition via a p53-independent pathway in human hepatoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Expression of mutated hepatitis B virus X genes in human hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Genetic alterations in hepatocellular carcinomas: association between loss of chromosome 4q and p53 gene mutations

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Transcriptional regulation of cellular and viral promoters by the hepatitis C virus core protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Transcriptional repression of p53 promoter by hepatitis C virus core protein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Biology of transforming growth factor beta in hepatocarcinogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Review: hepatitis B virus X-gene product: a promiscuous transcriptional activator

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Loss of heterozygosity and microsatellite instability in hepatocellular carcinoma in Taiwan.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Genomic heterogeneity in synchronous hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Hepatitis B virus X mutants, present in hepatocellular carcinoma tissue abrogate both the antiproliferative and transactivation effects of HBx.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Deletion of the E-cadherin gene in hepatitis B virus-positive Chinese hepatocellular carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Expression of functional CD40 in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

An early lesion in hepatic carcinogenesis: loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Expression of p73 and its relation to histopathology and prognosis in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Functional inactivation but not structural mutation of p53 causes liver cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Hepatitis B virus X protein inhibits p53 sequence-specific DNA binding, transcriptional activity, and association with transcription factor ERCC3

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Nucleolar Arf sequesters Mdm2 and activates p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Assessment of genetic changes in hepatocellular carcinoma by comparative genomic hybridization analysis: relationship to disease stage, tumor size, and cirrhosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Hypomethylation of chromosome 1 heterochromatin DNA correlates with q-arm copy gain in human hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Primary hepatocellular carcinoma and hepatitis B infection during childhood

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Chromosomal allelic imbalance evolving from liver cirrhosis to hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Regulation of transforming growth factor-beta 1 expression by the hepatitis B virus (HBV) X transactivator. Role in HBV pathogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Structural and functional characterization of interaction between hepatitis B virus X protein and the proteasome complex

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

Identification of three distinct regions of allelic deletions on the short arm of chromosome 8 in hepatocellular carcinoma

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

DNA ploidy of liver biopsies from patients with liver cirrhosis and hepatocellular carcinoma: a flow cytometric analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Identification of a 1-cM region of common deletion on 4q35 associated with progression of hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Hepatitis B virus X protein interferes with cellular DNA repair.

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

p53 protein accumulation in European hepatocellular carcinoma is not always dependent on p53 gene mutation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Germ-line mutations of the p16INK4(MTS1) gene occur in a subset of patients with hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Co-expression and regulation of Met and Ron proto-oncogenes in human hepatocellular carcinoma tissues and cell lines

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Screening for hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Hepatitis B X-gene expression in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

KAI1, a new metastasis suppressor gene, is reduced in metastatic hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Investigation of chromosomal aberrations in hepatocellular carcinoma by fluorescence in situ hybridization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

The E-cadherin gene is silenced by CpG methylation in human hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Cytogenetic analyses of hepatocellular carcinoma by in situ hybridization with a chromosome-specific DNA probe

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Frequent loss in chromosome 8p loci in liver cirrhosis accompanying hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Genetic aberrations detected by comparative genomic hybridization in hepatocellular carcinomas: their relationship to clinicopathological features

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Abnormal intracellular distribution of O6-alkylguanine-DNA-alkyltransferase in hepatitis B cirrhotic human liver: a potential cofactor in the development of hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Expression of mutant nuclear beta-catenin correlates with non-invasive hepatocellular carcinoma, absence of portal vein spread, and good prognosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Recurrent chromosomal abnormalities in hepatocellular carcinoma detected by comparative genomic hybridization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Hepatitis C virus core protein inhibits Fas- and tumor necrosis factor alpha-mediated apoptosis via NF-kappaB activation

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

pp60c-src activation in hepatocellular carcinoma of humans and LEC rats

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Overexpression and point mutations of p53 tumor suppressor gene in hepatocellular carcinomas in Hong Kong Chinese people

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Gene expressions of c-met and hepatocyte growth factor in chronic liver disease and hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Numerical chromosome aberrations in hepatocellular carcinoma detected by fluorescence in situ hybridization

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Difference in gene expression for matrix metalloproteinase-1 between early and advanced hepatocellular carcinomas

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Deletion mapping on the short arm of chromosome 8 in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Identification of differentially expressed genes in hepatocellular carcinoma with cDNA microarrays

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Expression of hepatocyte growth factor and its receptor c-met proto-oncogene in hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Failure to detect genetic alteration of the mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) gene in hepatocellular carcinomas in Japan

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Allelic loss and gain, but not genomic instability, as the major somatic mutation in primary hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

HBxAg in the liver from carrier patients with chronic hepatitis and cirrhosis

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Identification of homozygous deletions at chromosome 16q23 in aflatoxin B1 exposed hepatocellular carcinoma

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1205434

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1205434

1 reference

Dimensions Publication ID

3 August 2017

1032068786

0 references

1 reference