Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process (Q34614326)

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English	Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process	scientific article

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scholarly article

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Europe PubMed Central

PubMed publication ID

3 August 2017

Nuclear translocation of cardiac G protein-Coupled Receptor kinase 5 downstream of select Gq-activating hypertrophic ligands is a calmodulin-dependent process (English)

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Europe PubMed Central

PubMed publication ID

3 August 2017

G protein-coupled receptor

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4

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Erhe Gao

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object named as

Julie Bossuyt

9

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Donald M Bers

10

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author name string

Jessica I Gold

1

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Europe PubMed Central

PubMed publication ID

3 August 2017

Jeffrey S Martini

2

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Europe PubMed Central

PubMed publication ID

3 August 2017

Jonathan Hullmann

3

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Europe PubMed Central

PubMed publication ID

3 August 2017

J Kurt Chuprun

5

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Europe PubMed Central

PubMed publication ID

3 August 2017

Linda Lee

6

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Europe PubMed Central

PubMed publication ID

3 August 2017

Douglas G Tilley

7

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Europe PubMed Central

PubMed publication ID

3 August 2017

Joseph E Rabinowitz

8

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Europe PubMed Central

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3 August 2017

Walter J Koch

11

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3 August 2017

language of work or name

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publication date

5 March 2013

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Europe PubMed Central

PubMed publication ID

3 August 2017

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Europe PubMed Central

PubMed publication ID

3 August 2017

8

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Europe PubMed Central

PubMed publication ID

3 August 2017

3

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

e57324

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Europe PubMed Central

PubMed publication ID

3 August 2017

copyright license

Creative Commons Attribution 4.0 International

5 March 2013

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April 2022 Public Data File from Crossref

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Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication

1 reference

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G Protein-coupled receptor kinase 5 is localized to centrosomes and regulates cell cycle progression

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A role for GRK2 in myocardial ischemic injury: indicators of a potential future therapy and diagnostic

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Spatiotemporally distinct protein kinase D activation in adult cardiomyocytes in response to phenylephrine and endothelin

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Nuclear effects of G-protein receptor kinase 5 on histone deacetylase 5-regulated gene transcription in heart failure

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Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling.

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G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4

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G protein-coupled receptor kinases in normal and failing myocardium

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Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain

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7 July 2018

The Effect of Losartan and Amlodipine on Left Ventricular Diastolic Function and Atherosclerosis in Japanese Patients with Mild-to-Moderate Hypertension (J-ELAN) study

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7 July 2018

Level of G protein–Coupled Receptor Kinase-2 Determines Myocardial Ischemia/Reperfusion Injury via Pro- and Anti-Apoptotic Mechanisms

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Dynamic changes in lymphocyte GRK2 levels in cardiac transplant patients: a biomarker for left ventricular function.

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7 July 2018

G-protein-coupled receptor kinase 5 phosphorylates p53 and inhibits DNA damage-induced apoptosis

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G protein-coupled receptor kinase 5, overexpressed in the alpha-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression

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G-protein-coupled-receptor kinases mediate TNFα-induced NFκB signalling via direct interaction with and phosphorylation of IκBα.

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The G-protein-coupled receptor kinase 5 inhibits NFkappaB transcriptional activity by inducing nuclear accumulation of IkappaB alpha

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Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes

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7 July 2018

A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure

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7 July 2018

Effects of tezosentan on symptoms and clinical outcomes in patients with acute heart failure: the VERITAS randomized controlled trials

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Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection.

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Physiological roles of G protein-coupled receptor kinases and arrestins

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Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling

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Pathophysiological roles of G-protein-coupled receptor kinases

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7 July 2018

Protein kinase cascades in the regulation of cardiac hypertrophy

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589474

7 July 2018

Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure

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7 July 2018

G protein-coupled receptor kinase 5 contains a DNA-binding nuclear localization sequence

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Histone deacetylases 5 and 9 govern responsiveness of the heart to a subset of stress signals and play redundant roles in heart development

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589474

7 July 2018

Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3589474

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Differential functional expression of human myocardial G protein receptor kinases in left ventricular cardiac diseases

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Phosphorylation of G protein-coupled receptors: GPCR kinases in heart disease

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A predicted amphipathic helix mediates plasma membrane localization of GRK5

1 reference

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Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy

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Phosphatase inhibition leads to histone deacetylases 1 and 2 phosphorylation and disruption of corepressor interactions

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Characterization of lymphocyte beta 2-adrenoceptor signalling in patients with left ventricular volume overload disease

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Regulation of G protein-coupled receptor kinases

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Activation of the myocyte enhancer factor-2 transcription factor by calcium/calmodulin-dependent protein kinase-stimulated binding of 14-3-3 to histone deacetylase 5

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Regulation of G protein-coupled receptor kinase subtypes by calcium sensor proteins.

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CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

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Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart

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Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2

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Structure-function analysis of G protein-coupled receptor kinase-5. Role of the carboxyl terminus in kinase regulation

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Reciprocal in vivo regulation of myocardial G protein-coupled receptor kinase expression by beta-adrenergic receptor stimulation and blockade

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Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure

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Regulation of the G protein-coupled receptor kinase GRK5 by protein kinase C.

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Inhibition of G protein-coupled receptor kinase subtypes by Ca2+/calmodulin

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Phosphatidylinositol 4,5-bisphosphate (PIP2)-enhanced G protein-coupled receptor kinase (GRK) activity. Location, structure, and regulation of the PIP2 binding site distinguishes the GRK subfamilies

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Receptor-specific in vivo desensitization by the G protein-coupled receptor kinase-5 in transgenic mice

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Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

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Structure and mechanism of the G protein-coupled receptor kinases.

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1 reference

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1 reference

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Targeting the receptor-Gq interface to inhibit in vivo pressure overload myocardial hypertrophy

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Regulation of G-protein-coupled receptor kinase subtypes by calcium sensor proteins

1 reference

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inferred from PubMed ID database lookup

MEF2 activates a genetic program promoting chamber dilation and contractile dysfunction in calcineurin-induced heart failure

1 reference

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Losartan and amlodipine on myocardial structure and function: a prospective, randomized, clinical trial

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Identifiers

10.1371/JOURNAL.PONE.0057324

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

2013PLoSO...857324G

0 references

PMC publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

3 August 2017

ResearchGate publication ID

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