PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc (Q34589291)

3 August 2017

title

PI3K/AKT regulates aggrecan gene expression by modulating Sox9 expression and activity in nucleus pulposus cells of the intervertebral disc (English)

1 reference

3 August 2017

Chin-Chang Cheng

1 reference

3 August 2017

Yoshiyasu Uchiyama

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3 August 2017

Akihiko Hiyama

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3 August 2017

Sachin Gajghate

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3 August 2017

Irving M Shapiro

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3 August 2017

Makarand V Risbud

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3 August 2017

publication date

1 December 2009

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Journal of Cellular Physiology

3 August 2017

published in

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3 August 2017

volume

221

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3 August 2017

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3 August 2017

page(s)

668-676

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The PTEN-PI3K pathway: of feedbacks and cross-talks

3 August 2017

cites work

1 reference

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L-Sox5 and Sox6 drive expression of the aggrecan gene in cartilage by securing binding of Sox9 to a far-upstream enhancer

7 July 2018

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Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth

7 July 2018

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Signaling mechanisms leading to regulation of proliferation and differentiation of the mesenchymal chondrogenic cell line RCJ3.1C5.18 in response to IGF-I.

7 July 2018

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Downregulation of Akt activity contributes to the growth arrest induced by FGF in chondrocytes

7 July 2018

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7 July 2018

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Sox9 and p300 cooperatively regulate chromatin-mediated transcription

7 July 2018

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IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK.

7 July 2018

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Involvement of phosphoinositide 3-kinase signaling pathway in chondrocytic differentiation of ATDC5 cells: application of a gene-trap mutagenesis

7 July 2018

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Dexamethasone inhibits insulin-induced chondrogenesis of ATDC5 cells by preventing PI3K-Akt signaling and DNA binding of Runx2.

7 July 2018

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Transcriptional Co-activators CREB-binding Protein and p300 Regulate Chondrocyte-specific Gene Expression via Association with Sox9

7 July 2018

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MAPK signaling up-regulates the activity of hypoxia-inducible factors by its effects on p300

7 July 2018

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7 July 2018

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Involvement of the phosphoinositide 3-kinase/protein kinase B signaling pathway in insulin/IGF-I-induced chondrogenesis of the mouse embryonal carcinoma-derived cell line ATDC5.

7 July 2018

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Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer

7 July 2018

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SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.

7 July 2018

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Structural and functional characterization of the mouse Sox9 promoter: implications for campomelic dysplasia

7 July 2018

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Myogenic signaling of phosphatidylinositol 3-kinase requires the serine-threonine kinase Akt/protein kinase B.

7 July 2018

1 reference

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A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene

7 July 2018

1 reference

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

7 July 2018

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Distribution and diffusion of solutes in articular cartilage

7 July 2018

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Diffusion of small solutes into the intervertebral disc: as in vivo study

7 July 2018

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Transcriptional induction of SOX9 by NF-kappaB family member RelA in chondrogenic cells

7 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042319

PI3K/Akt signaling as a key regulatory pathway for chondrocyte terminal differentiation

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042319

SOX9 transduction increases chondroitin sulfate synthesis in cultured human articular chondrocytes without altering glycosyltransferase and sulfotransferase transcription

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042319

Nucleus pulposus cells express HIF-1 alpha under normoxic culture conditions: a metabolic adaptation to the intervertebral disc microenvironment

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042319

Nucleus pulposus cells upregulate PI3K/Akt and MEK/ERK signaling pathways under hypoxic conditions and resist apoptosis induced by serum withdrawal

27 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3042319

Signaling mechanisms leading to the regulation of differentiation and apoptosis of articular chondrocytes by insulin-like growth factor-1

27 October 2018

1 reference

12 December 2020

Water and electrolyte content of human intervertebral discs under variable load

1 reference

12 December 2020

TonEBP/OREBP is a regulator of nucleus pulposus cell function and survival in the intervertebral disc

1 reference

12 December 2020

Requirement of phosphatidylinositol 3-kinase/Akt signaling pathway for regulation of tissue inhibitor of metalloproteinases-3 gene expression by TGF-beta in human chondrocytes

1 reference

12 December 2020

Normoxic stabilization of HIF-1alpha drives glycolytic metabolism and regulates aggrecan gene expression in nucleus pulposus cells of the rat intervertebral disk

1 reference

12 December 2020

Identifiers

DOI

10.1002/JCP.21904

1 reference

3 August 2017

1 reference

3 August 2017

1 reference