Natural products as probes of cell biology: 20 years of didemnin research (Q34540054)

2 August 2017

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title

Natural products as probes of cell biology: 20 years of didemnin research (English)

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2 August 2017

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Madeleine M Joullié

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2 August 2017

Matthew D Vera

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2 August 2017

publication date

1 March 2002

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Medicinal Research Reviews

2 August 2017

published in

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

102-145

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2 August 2017

cites work

Toxins from ascidians.

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Antitumor compounds from tunicates

21 January 2018

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Antineoplastic activity of didemnin congeners: nordidemnin and modified chain analogues

21 January 2018

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Crystal and molecular structure of didemnin B, an antiviral and cytotoxic depsipeptide

21 January 2018

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In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells

21 January 2018

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Structure--activity relationships of the didemnins.

21 January 2018

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Tamandarins A and B: new cytotoxic depsipeptides from a Brazilian ascidian of the family Didemnidae

21 January 2018

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Defense of Ascidians and Their Conspicuous Larvae: Adult vs. Larval Chemical Defenses

21 January 2018

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Inhibition of RNA viruses in vitro and in Rift Valley fever-infected mice by didemnins A and B

21 January 2018

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Didemnins A and B. Effectiveness against cutaneous herpes simplex virus in mice

21 January 2018

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In vivo effect of didemnin B on two tumors of the rat.

21 January 2018

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Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

21 January 2018

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Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill

21 January 2018

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Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

21 January 2018

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Phase I/II clinical trial of didemnin B in non-small-cell lung cancer: neuromuscular toxicity is dose-limiting

21 January 2018

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A phase I clinical trial of didemnin B

21 January 2018

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Phase II clinical trial of didemnin B in previously treated small cell lung cancer

21 January 2018

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Chemical Synthesis of Natural Product Peptides: Coupling Methods for the Incorporation of Noncoded Amino Acids into Peptides

21 January 2018

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Total syntheses and biological investigations of tamandarins A and B and tamandarin A analogs

21 January 2018

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Conformational analysis of dehydrodidemnin B (aplidine) by NMR spectroscopy and molecular mechanics/dynamics calculations

21 January 2018

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Total synthesis of a conformationally constrained didemnin B analog

21 January 2018

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A simple method for displaying the hydropathic character of a protein

21 January 2018

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Understanding and controlling the cell cycle with natural products

21 January 2018

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Further Evidence that Elongation Factor 1 Remains Bound to Ribosomes during Peptide Chain Elongation

21 January 2018

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Characterization of the elongation factors from calf brain. 3. Properties of the GTPase activity of EF-1 alpha and mode of action of kirromycin

21 January 2018

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Didemnin binds to the protein palmitoyl thioesterase responsible for infantile neuronal ceroid lipofuscinosis

21 January 2018

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The antiproliferative agent didemnin B uncompetitively inhibits palmitoyl protein thioesterase

21 January 2018

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Apoptosis and disease: regulation and clinical relevance of programmed cell death

21 January 2018

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Mitochondrial cytochrome c release is caspase-dependent and does not involve mitochondrial permeability transition in didemnin B-induced apoptosis

21 January 2018

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Rapamycin inhibits didemnin B-induced apoptosis in human HL-60 cells: evidence for the possible involvement of FK506-binding protein 25

21 January 2018

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Benzophenone photophores in biochemistry.

21 January 2018

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Synthesis and biological evaluation of didemnin photoaffinity analogues

21 January 2018

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21 January 2018

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Total Synthesis of Dehydrodidemnin B. Use of Uronium and Phosphonium Salt Coupling Reagents in Peptide Synthesis in Solution†

21 January 2018

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A New Paclitaxel Photoaffinity Analog with a 3-(4-Benzoylphenyl)propanoyl Probe for Characterization of Drug-Binding Sites on Tubulin and P-Glycoprotein

21 January 2018

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21 January 2018

Identifiers

DOI

10.1002/MED.10003

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2 August 2017

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