The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough (Q34516431)

2 August 2017

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title

The paradox of nitric oxide in cirrhosis and portal hypertension: too much, not enough (English)

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2 August 2017

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Reiner Wiest

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2 August 2017

Roberto J Groszmann

series ordinal

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2 August 2017

language of work or name

English

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publication date

1 February 2002

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2 August 2017

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2 August 2017

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2 August 2017

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2 August 2017

page(s)

478-491

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Reduction of the increased portal vascular resistance of the isolated perfused cirrhotic rat liver by vasodilators

2 August 2017

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Verapamil favorably influences hepatic microvascular exchange and function in rats with cirrhosis of the liver

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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

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Regulatory functions of the vascular endothelium

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The nitric oxide synthase family of proteins

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Mechanotransduction in Endothelial Cells: Temporal Signaling Events in Response to Shear Stress

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Hepatic and splanchnic nitric oxide activity in patients with cirrhosis

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Role of nitric oxide formation in the regulation of haemodynamics and the release of noradrenaline and adrenaline

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NO-mediated vasodilation in the rat liver. Role of hepatocytes and liver endothelial cells

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Shear stress-induced release of nitric oxide from endothelial cells grown on beads

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Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids

21 January 2018

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The multiple organ dysfunction syndrome caused by endotoxin in the rat: attenuation of liver dysfunction by inhibitors of nitric oxide synthase

21 January 2018

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Endothelin induced contractility of stellate cells from normal and cirrhotic rat liver: implications for regulation of portal pressure and resistance

21 January 2018

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Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells

21 January 2018

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Gene expression of endothelin-1 and ET(A) and ET(B) receptors in human cirrhosis: relationship with hepatic hemodynamics.

21 January 2018

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21 January 2018

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Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries

21 January 2018

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The L-arginine-nitric oxide pathway: role in atherosclerosis and therapeutic implications

21 January 2018

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Atherosclerosis and the two faces of endothelial nitric oxide synthase

21 January 2018

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An L-arginine/nitric oxide pathway present in human platelets regulates aggregation

21 January 2018

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https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Nitric oxide: an endogenous modulator of leukocyte adhesion

21 January 2018

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https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action

21 January 2018

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Multiple organ failure. Pathophysiology and potential future therapy

21 January 2018

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Nitric oxide and portal hypertension: its role in the regulation of intrahepatic and splanchnic vascular resistance

21 January 2018

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S-nitrosylation: spectrum and specificity

21 January 2018

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Nitric oxide activates cyclooxygenase enzymes.

21 January 2018

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Biochemistry of Nitric Oxide and Its Redox-Activated Forms

21 January 2018

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Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling

21 January 2018

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Endothelial nitric oxide synthase is regulated by tyrosine phosphorylation and interacts with caveolin-1

21 January 2018

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Phosphorylation and subcellular translocation of endothelial nitric oxide synthase

21 January 2018

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Molecular control of nitric oxide synthases in the cardiovascular system

21 January 2018

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Caveolin versus calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase

21 January 2018

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Dissecting the interaction between nitric oxide synthase (NOS) and caveolin. Functional significance of the nos caveolin binding domain in vivo

21 January 2018

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Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin

21 January 2018

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Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors

21 January 2018

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Effects of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells

21 January 2018

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Regulation of cholesterol and bile acid homoeostasis in bile-obstructed rats

21 January 2018

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Liver fibrosis in overweight patients

21 January 2018

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Two sterol regulatory element-like sequences mediate up-regulation of caveolin gene transcription in response to low density lipoprotein free cholesterol

21 January 2018

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https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans

21 January 2018

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https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Effects of l-arginine on the systemic, mesenteric, and Hepatic circulation in patients with cirrhosis

21 January 2018

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Endothelial dysfunction in atherosclerotic mice: improved relaxation by combined supplementation with L-arginine-tetrahydrobiopterin and enhanced vasoconstriction by endothelin

21 January 2018

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Tetrahydrobiopterin restores endothelial function in hypercholesterolemia.

21 January 2018

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Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats

21 January 2018

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Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase

21 January 2018

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Antiatherosclerotic activity of drugs in relation to nitric oxide function

21 January 2018

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https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

How does ascorbic acid prevent endothelial dysfunction?

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

The role of nitric oxide in the vascular hyporesponsiveness to methoxamine in portal hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Nitric oxide synthase (NOS) inhibition for one week improves renal sodium and water excretion in cirrhotic rats with ascites.

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Dynamic activation of endothelial nitric oxide synthase by Hsp90.

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Signal transduction of eNOS activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Keratinocyte growth factor promotes goblet cell differentiation through regulation of goblet cell silencer inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Increased nitric oxide synthase expression in arterial vessels of cirrhotic rats with ascites

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Evidence against a role for inducible nitric oxide synthase in the hyperdynamic circulation of portal-hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

The role of inducible nitric oxide synthase in vascular hyporeactivity of endotoxin-treated and portal hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Abnormal regulation of aortic NOS2 and NOS3 activity and expression from portal vein-stenosed rats after lipopolysaccharide administration

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Endothelial cell production of nitrogen oxides in response to interferon gamma in combination with tumor necrosis factor, interleukin-1, or endotoxin

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Regulation of nitric oxide synthesis by proinflammatory cytokines in human umbilical vein endothelial cells. Elevations in tetrahydrobiopterin levels enhance endothelial nitric oxide synthase specific activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Cytokines Stimulate GTP Cyclohydrolase I Gene Expression in Cultured Human Umbilical Vein Endothelial Cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Cytokine-induced venodilatation in humans in vivo: eNOS masquerading as iNOS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Endothelial calcium-calmodulin dependent nitric oxide synthase in the in vitro vascular hyporeactivity of portal hypertensive rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Temporal relationship of peripheral vasodilatation, plasma volume expansion and the hyperdynamic circulatory state in portal-hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Peripheral arterial vasodilation hypothesis: a proposal for the initiation of renal sodium and water retention in cirrhosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Administration of N omega-nitro-L-arginine ameliorates portal-systemic shunting in portal-hypertensive rats.

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Cyclic strain upregulates nitric oxide synthase in cultured bovine aortic endothelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Hemostasis in liver disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Cytokines and fibrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Hepatic stellate cells and intrahepatic modulation of portal pressure

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Hypercholesterolemia increases endothelial superoxide anion production

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Chronic treatment with polyethylene-glycolated superoxide dismutase partially restores endothelium-dependent vascular relaxations in cholesterol-fed rabbits

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Pathogenesis of liver fibrosis: role of oxidative stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Lipid peroxidation and endothelial cell injury: implications in atherosclerosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Vascular function in the forearm of hypercholesterolaemic patients off and on lipid-lowering medication

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Nitroglycerin improves the hemodynamic response to vasopressin in portal hypertension

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

Nitric oxide release from a single cell measured in situ by a porphyrinic-based microsensor

21 January 2018

1 reference

https://api.crossref.org/works/10.1053%2FJHEP.2002.31432

21 January 2018

Identifiers

DOI

10.1053/JHEP.2002.31432

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2 August 2017

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