How does ascorbic acid prevent endothelial dysfunction? (Q33989882)

30 July 2017

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title

How does ascorbic acid prevent endothelial dysfunction? (English)

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30 July 2017

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May JM

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30 July 2017

publication date

1 May 2000

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Free Radical Biology and Medicine

30 July 2017

published in

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30 July 2017

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30 July 2017

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30 July 2017

page(s)

1421-1429

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Atherosclerosis — An Inflammatory Disease

30 July 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Antioxidants and Atherosclerotic Heart Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Nitric oxide and hypercholesterolemia: a matter of oxidation and reduction?

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C attenuates abnormal vasomotor reactivity in spasm coronary arteries in patients with coronary spastic angina.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C improves endothelial function of conduit arteries in patients with chronic heart failure

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Antioxidant vitamin C improves endothelial dysfunction in chronic smokers

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C Improves Endothelial Dysfunction of Epicardial Coronary Arteries in Hypertensive Patients

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C improves endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Low plasma ascorbic acid independently predicts the presence of an unstable coronary syndrome.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C deficiency and risk of myocardial infarction: prospective population study of men from eastern Finland

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C increases nitric oxide availability in coronary atherosclerosis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Long-Term Ascorbic Acid Administration Reverses Endothelial Vasomotor Dysfunction in Patients With Coronary Artery Disease

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C improves endothelium-dependent vasodilation by restoring nitric oxide activity in essential hypertension.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C improves endothelium-dependent vasodilation in forearm resistance vessels of humans with hypercholesterolemia

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

The distribution of ascorbic acid between various cellular components of blood, in normal individuals, and its relation to the plasma concentration

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Human requirements and needs. Vitamin C status: methods and findings

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Determination of optimal vitamin C requirements in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Existence and Characteristics of Na+-Dependent Active Transport of Ascorbic Acid in Guinea Pig

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Na+-dependent, potential-sensitive l-ascorbate transport across brush border membrane vesicles from kidney cortex

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Transport of ascorbic acid and other water-soluble vitamins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Erythrocyte ascorbate recycling: antioxidant effects in blood

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Efflux of hepatic ascorbate: a potential contributor to the maintenance of plasma vitamin C.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

A family of mammalian Na+-dependent L-ascorbic acid transporters

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Cloning and functional characterization of the human sodium-dependent vitamin C transporters hSVCT1 and hSVCT2

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Human Na(+)-dependent vitamin C transporter 1 (hSVCT1): primary structure, functional characteristics and evidence for a non-functional splice variant

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Accumulation of vitamin C (ascorbate) and its oxidized metabolite dehydroascorbic acid occurs by separate mechanisms

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Ascorbate function and metabolism in the human erythrocyte

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

The reduction of dehydroascorbic acid by human erythrocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Distribution of ascorbic acid, metabolites and analogues in man and animals

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

The uptake of ascorbic acid into human umbilical vein endothelial cells and its effect on oxidant insult

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Both Intracellular and Extracellular Vitamin C Inhibit Atherogenic Modification of LDL by Human Vascular Endothelial Cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Ascorbate is an outstanding antioxidant in human blood plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

The antioxidants of human extracellular fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Protective effect of lipophilic derivatives of ascorbic acid on lipid peroxide-induced endothelial injury

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Coantioxidants make alpha-tocopherol an efficient antioxidant for low-density lipoprotein

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Human Atherosclerotic Plaque Contains Both Oxidized Lipids and Relatively Large Amounts of α-Tocopherol and Ascorbate

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Protective role of intracellular glutathione against oxidized low density lipoprotein in cultured endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C protects human arterial smooth muscle cells against atherogenic lipoproteins: effects of antioxidant vitamins C and E on oxidized LDL-induced adaptive increases in cystine transport and glutathione

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Vitamin C protects human vascular smooth muscle cells against apoptosis induced by moderately oxidized LDL containing high levels of lipid hydroperoxides

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

alpha-Tocopherol, ascorbic acid, and rutin inhibit synergistically the copper-promoted LDL oxidation and the cytotoxicity of oxidized LDL to cultured endothelial cells.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Role of superoxide in endothelial-cell modification of low-density lipoproteins

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Cell biologists explore 'tiny caves'.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Direct Interaction of Endothelial Nitric-oxide Synthase and Caveolin-1 Inhibits Synthase Activity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

In situ flow activates endothelial nitric oxide synthase in luminal caveolae of endothelium with rapid caveolin dissociation and calmodulin association

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Improved methods to measure end products of nitric oxide in biological fluids: nitrite, nitrate, and S-nitrosothiols

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Role of Ascorbate and Protein Thiols in the Release of Nitric oxide from S-Nitroso-Albumin and S-Nitroso-Glutathione in Human Plasma

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

S-nitrosohaemoglobin: a dynamic activity of blood involved in vascular control

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Biochemical characterization of human S-nitrosohemoglobin. Effects on oxygen binding and transnitrosation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

NO+, NO, and NO- donation by S-nitrosothiols: implications for regulation of physiological functions by S-nitrosylation and acceleration of disulfide formation

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

The nitric oxide/ascorbate cycle: how neurones may control their own oxygen supply

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Ascorbate-Nitrite Reaction: Possible Means of Blocking the Formation of Carcinogenic N -Nitroso Compounds

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

The L-arginine:nitric oxide pathway is the major source of plasma nitrite in fasted humans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Pharmacokinetic studies of various preparations of glyceryl trinitrate

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

A rapid and simple method for the measurement of nitrite and nitrate in plasma by high performance capillary electrophoresis

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Nitric oxide in Tanzanian children with malaria: inverse relationship between malaria severity and nitric oxide production/nitric oxide synthase type 2 expression

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Nonenzymatic nitric oxide production in humans

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Hypercholesterolemia increases endothelial superoxide anion production

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Ascorbate Prevents the Interaction of Superoxide and Nitric Oxide Only at Very High Physiological Concentrations

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

The Interstitium of the Human Arterial Wall Contains Very Large Amounts of Extracellular Superoxide Dismutase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Nitric oxide synthesis is impaired in glutathione-depleted human umbilical vein endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

L-2-Oxothiazolidine-4-carboxylic acid reverses endothelial dysfunction in patients with coronary artery disease.

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Nitric oxide exposure and sulfhydryl modulation alter L-arginine transport in cultured pulmonary artery endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Thiol Dependence of Nitric Oxide Synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Cysteine 99 of endothelial nitric oxide synthase (NOS-III) is critical for tetrahydrobiopterin-dependent NOS-III stability and activity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Nitric oxide-induced inhibition of lung endothelial cell nitric oxide synthase via interaction with allosteric thiols: role of thioredoxin in regulation of catalytic activity

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Sulfhydryl-disulfide modulation and the role of disulfide oxidoreductases in regulation of the catalytic activity of nitric oxide synthase in pulmonary artery endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Brain nitric oxide synthase is a biopterin- and flavin-containing multi-functional oxido-reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Reduction by tetrahydrobiopterin of H2O2-induced endothelial cell injury

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Antioxidative Activity of 5,6,7,8-Tetrahydrobiopterin and its Inhibitory Effect on Paraquat-Induced Cell Toxicity in Cultured Rat Hepatocytes

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Acceleration of oxidative stress-induced endothelial cell death by nitric oxide synthase dysfunction accompanied with decrease in tetrahydrobiopterin content

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Protective effects of tetrahydrobiopterin against nitric oxide-induced endothelial cell death

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Kinetics and Mechanism of Tetrahydrobiopterin-induced Oxidation of Nitric Oxide

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Tetrahydrobiopterin inhibits monomerization and is consumed during catalysis in neuronal NO synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Ca2+/calmodulin-dependent formation of hydrogen peroxide by brain nitric oxide synthase

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Oxidation of tetrahydrobiopterin by peroxynitrite: implications for vascular endothelial function

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Stopped-flow kinetic study of the reaction of ascorbic acid with peroxynitrite

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

The role of ascorbate in the prolyl hydroxylase reaction

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Ascorbate and dehydroascorbate modulate nitric oxide-induced vasodilations of rat coronary arteries

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Studies of the heme coordination and ligand binding properties of soluble guanylyl cyclase (sGC): characterization of Fe(II)sGC and Fe(II)sGC(CO) by electronic absorption and magnetic circular dichroism spectroscopies and failure of CO to activate t

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

Dietary supplement with vitamin C prevents nitrate tolerance

1 reference

https://api.crossref.org/works/10.1016%2FS0891-5849%2800%2900269-0

7 January 2021

10.1016/S0891-5849(00)00269-0

Identifiers

DOI

1 reference

30 July 2017

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