Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits (Q34509797)

12 December 2020

FAD mutations in presenilin-1 or amyloid precursor protein decrease the efficacy of a gamma-secretase inhibitor: evidence for direct involvement of PS1 in the gamma-secretase cleavage complex.

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12 December 2020

In vivo 2-deoxyglucose administration preserves glucose and glutamate transport and mitochondrial function in cortical synaptic terminals after exposure to amyloid beta-peptide and iron: evidence for a stress response

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12 December 2020

Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets

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12 December 2020

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

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12 December 2020

Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing

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12 December 2020

Identification of syntaxin 1A as a novel binding protein for presenilin-1.

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12 December 2020

NF-kappaB in neuronal plasticity and neurodegenerative disorders

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12 December 2020

Anti-inflammatory drugs in the fight against Alzheimer's disease

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12 December 2020

Glucose deprivation elicits neurofibrillary tangle-like antigenic changes in hippocampal neurons: prevention by NGF and bFGF

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12 December 2020

Cerebral microvascular pathology in aging and Alzheimer's disease

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12 December 2020

4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease

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12 December 2020

Folate and carcinogenesis: an integrated scheme

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12 December 2020

The presenilin 2 loop domain interacts with the mu-calpain C-terminal region

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12 December 2020

Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation

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12 December 2020

Synaptic transmission and hippocampal long-term potentiation in transgenic mice expressing FAD-linked presenilin 1.

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12 December 2020

Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats.

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12 December 2020

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

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12 December 2020

Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices

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12 December 2020

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

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12 December 2020

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease

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12 December 2020

Calcium ionophore increases amyloid beta peptide production by cultured cells

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12 December 2020

Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease.

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12 December 2020

Calcium-activated neutral proteinase (calpain) system in aging and Alzheimer's disease

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12 December 2020

Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons

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12 December 2020

2-Deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for the involvement of stress proteins

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12 December 2020

Presenilin 2 interacts with sorcin, a modulator of the ryanodine receptor

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12 December 2020

Oxidative processes in Alzheimer's disease: the role of abeta-metal interactions

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12 December 2020

Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction.

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12 December 2020

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

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12 December 2020

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

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12 December 2020

Functional phenotype in transgenic mice expressing mutant human presenilin-1.

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12 December 2020

Altered binding of mutated presenilin with cytoskeleton-interacting proteins

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12 December 2020

Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation

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12 December 2020

4-hydroxynonenal, a lipid peroxidation product, impairs glutamate transport in cortical astrocytes.

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12 December 2020

Calcium ionophore A23187 specifically decreases the secretion of beta-secretase cleaved amyloid precursor protein during apoptosis in primary rat cortical cultures

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12 December 2020

Identification of the ankyrin-binding domain of the mouse T-lymphoma cell inositol 1,4,5-trisphosphate (IP3) receptor and its role in the regulation of IP3-mediated internal Ca2+ release

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12 December 2020

Transglutaminase activity is increased in Alzheimer's disease brain

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12 December 2020

Mechanisms of neuronal degeneration in Alzheimer's disease

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12 December 2020

Mitochondrial permeability transition in apoptosis and necrosis

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12 December 2020

Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein

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12 December 2020

Decoding of cytosolic calcium oscillations in the mitochondria

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12 December 2020

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

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12 December 2020

Interaction between DNA-dependent protein kinase and a novel protein, KIP

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12 December 2020

Fibroblast models of neurological disorders: fluorescence measurement studies

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12 December 2020

Mitochondrial participation in the intracellular Ca2+ network

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12 December 2020

Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease

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12 December 2020

Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1

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12 December 2020

Decreased synaptic density in aged brains and its prevention by rearing under enriched environment as revealed by synaptophysin contents

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12 December 2020

Evidence for excitoprotective and intraneuronal calcium-regulating roles for secreted forms of the beta-amyloid precursor protein

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12 December 2020

Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons

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12 December 2020

4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats

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12 December 2020

Linguistic ability in early life and cognitive function and Alzheimer's disease in late life. Findings from the Nun Study

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12 December 2020

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

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12 December 2020

Elemental analysis of neurofibrillary tangles in Alzheimer's disease using proton-induced X-ray analysis

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12 December 2020

Molecular biology of glutamate receptors in the central nervous system and their role in excitotoxicity, oxidative stress and aging

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12 December 2020

Apolipoprotein E allele-specific antioxidant activity and effects on cytotoxicity by oxidative insults and beta-amyloid peptides

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12 December 2020

Alzheimer's presenilin 1 is a putative membrane receptor for rab GDP dissociation inhibitor

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12 December 2020

Dietary restriction increases the number of newly generated neural cells, and induces BDNF expression, in the dentate gyrus of rats

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12 December 2020

Presenilin-mediated modulation of capacitative calcium entry

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12 December 2020

Gene-expression profile of the ageing brain in mice

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12 December 2020

Dietary restriction benefits learning and motor performance of aged mice.

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12 December 2020

Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal

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12 December 2020

alpha-calcium-calmodulin-dependent kinase II is associated with paired helical filaments of Alzheimer's disease

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12 December 2020

Incidence of dementia and Alzheimer disease in 2 communities: Yoruba residing in Ibadan, Nigeria, and African Americans residing in Indianapolis, Indiana

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12 December 2020

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide

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12 December 2020

Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

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12 December 2020

The Ca2+ transport mechanisms of mitochondria and Ca2+ uptake from physiological-type Ca2+ transients

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12 December 2020

Identification of a novel calcium-binding protein that interacts with the integrin alphaIIb cytoplasmic domain

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12 December 2020

beta-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: implications to Alzheimer's disease

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12 December 2020

Physical activity and antidepressant treatment potentiate the expression of specific brain-derived neurotrophic factor transcripts in the rat hippocampus

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12 December 2020

Impaired cerebromicrovascular perfusion. Summary of evidence in support of its causality in Alzheimer's disease.

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12 December 2020

Presenilin 1 protein directly interacts with Bcl-2

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12 December 2020

The mitochondrial permeability transition

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12 December 2020

Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons

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12 December 2020

Identification of a novel PSD-95/Dlg/ZO-1 (PDZ)-like protein interacting with the C terminus of presenilin-1

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12 December 2020

Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation

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12 December 2020

Sorting of calcium signals at the junctions of endoplasmic reticulum and mitochondria

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12 December 2020

Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury

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12 December 2020

Stress exacerbates neuron loss and cytoskeletal pathology in the hippocampus

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12 December 2020

Folic acid, homocysteine and one-carbon metabolism: a review of the essential biochemistry

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12 December 2020

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

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12 December 2020

Calcineurin immunoreactivity in Alzheimer's disease

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12 December 2020

4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, Impairs Signal Transduction Associated with Muscarinic Acetylcholine and Metabotropic Glutamate Receptors: Possible Action on Gαq/11

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12 December 2020

Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations.

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12 December 2020

Effects of Exogenous Heat Shock Protein (hsp70) on Neuronal Calcium Flux

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12 December 2020

Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1

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12 December 2020

Stabilization of calcium release channel (ryanodine receptor) function by FK506-binding protein

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12 December 2020

Aggregated Amyloid-β Protein Induces Cortical Neuronal Apoptosis and Concomitant “Apoptotic” Pattern of Gene Induction

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12 December 2020

Hippocampal neurons predisposed to neurofibrillary tangle formation are enriched in type II calcium/calmodulin-dependent protein kinase

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12 December 2020

Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus.

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12 December 2020

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

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12 December 2020

Alterations in the ryanodine receptor calcium release channel correlate with Alzheimer's disease neurofibrillary and beta-amyloid pathologies

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12 December 2020

Interaction of Presenilins with the Filamin Family of Actin-Binding Proteins

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12 December 2020

Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons

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12 December 2020

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice

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12 December 2020

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal

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12 December 2020

NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults

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12 December 2020

Secreted forms of beta-amyloid precursor protein protect hippocampal neurons against amyloid beta-peptide-induced oxidative injury

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12 December 2020

Mitochondrial calcium spiking: a transduction mechanism based on calcium-induced permeability transition involved in cell calcium signalling

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12 December 2020

"Apoptotic" biochemical cascades in synaptic compartments: roles in adaptive plasticity and neurodegenerative disorders

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12 December 2020

Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice

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12 December 2020

Secreted forms of beta-amyloid precursor protein modulate dendrite outgrowth and calcium responses to glutamate in cultured embryonic hippocampal neurons

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12 December 2020

Memory impairment and neuronal dysfunction induced by beta-amyloid protein in rats.

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12 December 2020

Learning-dependent synaptic modifications in the cerebellar cortex of the adult rat persist for at least four weeks.

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12 December 2020

Functional outcome in rats transferred to an enriched environment 15 days after focal brain ischemia

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12 December 2020

Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport

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12 December 2020

Mitochondrial production of reactive oxygen species in cortical neurons following exposure to N-methyl-D-aspartate

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12 December 2020

Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptor-dependent mechanism

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12 December 2020

Beta-amyloid peptide blocks the fast-inactivating K+ current in rat hippocampal neurons

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12 December 2020

Pivotal role of mitochondrial calcium uptake in neural cell apoptosis and necrosis

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12 December 2020

Calcium as sculptor and destroyer of neural circuitry

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12 December 2020

The role of folic acid in deficiency states and prevention of disease.

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12 December 2020

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

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12 December 2020

Obesity and its comorbid conditions

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12 December 2020

Glutamate as a neurotransmitter in the brain: review of physiology and pathology

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12 December 2020

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

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12 December 2020

Calsenilin reverses presenilin-mediated enhancement of calcium signaling

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12 December 2020

Cleavage of fluorogenic substrates for APP-processing proteases by human brain extracts. Ca(2+)-substrate interaction is responsible for Ca2+ stimulation of the neural protease activity.

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12 December 2020

A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain

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12 December 2020

Activation of K+ channels and suppression of neuronal activity by secreted beta-amyloid-precursor protein.

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12 December 2020

Transglutaminase cross-linking of the tau protein

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12 December 2020

Postoperative environmental enrichment attenuates fimbria-fornix lesion-induced impairments in Morris maze performance

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12 December 2020

Nuclear microscope analysis in Alzheimer's and Parkinson's disease: A review

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12 December 2020

Enriched environment increases neurogenesis in the adult rat dentate gyrus and improves spatial memory

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12 December 2020

Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation

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12 December 2020

Stroke risk factors and stroke prevention

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12 December 2020

Lymphocytes and neutrophils as peripheral models to study the effect of beta-amyloid on cellular calcium signalling in Alzheimer's disease

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12 December 2020

Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau

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12 December 2020

Direct association of presenilin-1 with beta-catenin

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12 December 2020

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

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12 December 2020

Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor.

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12 December 2020

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

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12 December 2020

Secreted form of β-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices

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12 December 2020

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

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12 December 2020

Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.

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12 December 2020

Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment

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12 December 2020

A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein

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12 December 2020

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease

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12 December 2020

Corticosterone exacerbates kainate-induced alterations in hippocampal tau immunoreactivity and spectrin proteolysis in vivo.

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12 December 2020

Education and Other Measures of Socioeconomic Status and Risk of Incident Alzheimer Disease in a Defined Population of Older Persons

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12 December 2020

More hippocampal neurons in adult mice living in an enriched environment

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12 December 2020

Calcium-destabilizing and neurodegenerative effects of aggregated beta-amyloid peptide are attenuated by basic FGF.

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12 December 2020

Neuroprotective signaling and the aging brain: take away my food and let me run.

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12 December 2020

4-Hydroxynonenal, a product of lipid peroxidation, inhibits dephosphorylation of the microtubule-associated protein tau

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12 December 2020

Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo

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12 December 2020

A synthetic inhibitor of p53 protects neurons against death induced by ischemic and excitotoxic insults, and amyloid beta-peptide.

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12 December 2020

17?-Estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid ?-peptide and iron

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12 December 2020

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

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12 December 2020

Amyloid, the presenilins and Alzheimer's disease

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12 December 2020

Effects of complex experience on somatic growth and organ development in rats

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12 December 2020

Estrogen regulates metabolism of Alzheimer amyloid beta precursor protein

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12 December 2020

Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis

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12 December 2020

Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

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12 December 2020

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

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12 December 2020

Mechanisms of immune regulation in Alzheimer's disease: a viewpoint.

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12 December 2020

The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis

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12 December 2020

Alzheimer's presenilin-1 mutation potentiates inositol 1,4,5-trisphosphate-mediated calcium signaling in Xenopus oocytes

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12 December 2020

Calcium signalling--an overview

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12 December 2020

Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain

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12 December 2020

Role of mitochondrial Ca2+ regulation in neuronal and glial cell signalling

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12 December 2020

Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease

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12 December 2020

Alzheimer's disease associated presenilin 1 interacts with HC5 and ZETA, subunits of the catalytic 20S proteasome

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12 December 2020

Environmental enrichment and cortical injury: behavioral and anatomical consequences of frontal cortex lesions

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12 December 2020

Reconstituted adenine nucleotide translocase forms a channel for small molecules comparable to the mitochondrial permeability transition pore

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12 December 2020

Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives

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12 December 2020

The calmodulin-binding domain in the mouse type 1 inositol 1,4,5-trisphosphate receptor

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12 December 2020

Active site-directed antibodies identify calpain II as an early-appearing and pervasive component of neurofibrillary pathology in Alzheimer's disease

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12 December 2020

Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study

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12 December 2020

Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults

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12 December 2020

Truncated apolipoprotein E (ApoE) causes increased intracellular calcium and may mediate ApoE neurotoxicity.

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12 December 2020

Structure-function relationships in sorcin, a member of the penta EF-hand family. Interaction of sorcin fragments with the ryanodine receptor and an Escherichia coli model system

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12 December 2020

Dietary restriction and 2-deoxyglucose administration reduce focal ischemic brain damage and improve behavioral outcome: evidence for a preconditioning mechanism

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12 December 2020

Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid.

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12 December 2020

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response

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12 December 2020

Ultrastructural localization of sorcin, a 22 kDa calcium binding protein, in the rat caudate-putamen nucleus: Association with ryanodine receptors and intracellular calcium release

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12 December 2020

Antigenic changes similar to those seen in neurofibrillary tangles are elicited by glutamate and Ca2+ influx in cultured hippocampal neurons

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12 December 2020

Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux

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12 December 2020

A role for the mitochondrion in the protection of cells against calcium overload?

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12 December 2020

Exercise and risk of stroke in male physicians

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12 December 2020

Seminars in medicine of the Beth Israel Deaconess Medical Center. Caloric intake and aging

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12 December 2020

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

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12 December 2020

The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity

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12 December 2020