Stressed to death: regulation of apoptotic signaling pathways by the heat shock proteins (Q34467940)

2 August 2017

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title

Stressed to death: regulation of apoptotic signaling pathways by the heat shock proteins (English)

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2 August 2017

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Beere HM

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2 August 2017

publication date

31 July 2001

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Science's STKE : signal transduction knowledge environment

2 August 2017

published in

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2 August 2017

volume

2001

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2 August 2017

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2 August 2017

page(s)

re1

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The function of heat-shock proteins in stress tolerance: degradation and reactivation of damaged proteins

2 August 2017

cites work

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https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Stress management - heat shock protein-70 and the regulation of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Suicidal tendencies: apoptotic cell death by caspase family proteinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Mitochondria and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Cytochrome c and dATP-mediated oligomerization of Apaf-1 is a prerequisite for procaspase-9 activation

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Autoactivation of procaspase-9 by Apaf-1-mediated oligomerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Role of the Human Heat Shock Protein hsp70 in Protection against Stress-Induced Apoptosis

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Negative regulation of the Apaf-1 apoptosome by Hsp70

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Hsp27 negatively regulates cell death by interacting with cytochrome c.

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Signal transduction by the JNK group of MAP kinases

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

JNK targets p53 ubiquitination and degradation in nonstressed cells

21 January 2018

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https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

MEKK1/JNK signaling stabilizes and activates p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Regulation of c-Myc through phosphorylation at Ser-62 and Ser-71 by c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

p53 induces apoptosis by caspase activation through mitochondrial cytochrome c release.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

c-Myc-induced sensitization to apoptosis is mediated through cytochrome c release

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Bcl-2 undergoes phosphorylation by c-Jun N-terminal kinase/stress-activated protein kinases in the presence of the constitutively active GTP-binding protein Rac1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

BCL-2 is phosphorylated and inactivated by an ASK1/Jun N-terminal protein kinase pathway normally activated at G(2)/M.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Hsp72 functions as a natural inhibitory protein of c-Jun N-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

ATPase activity of the heat shock protein hsp72 is dispensable for its effects on dephosphorylation of stress kinase JNK and on heat-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

The chaperone function of hsp70 is required for protection against stress-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Heat shock protein 72 modulates pathways of stress-induced apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Cellular survival: a play in three Akts

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Regulation of cell death protease caspase-9 by phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Induction of NF-kappaB by the Akt/PKB kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

ch-IAP1, a Member of the Inhibitor-of-Apoptosis Protein Family, Is a Mediator of the Antiapoptotic Activity of the v-Rel Oncoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Disruption of hsp90 function results in degradation of the death domain kinase, receptor-interacting protein (RIP), and blockage of tumor necrosis factor-induced nuclear factor-kappaB activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Daxx, a Novel Fas-Binding Protein That Activates JNK and Apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Inhibition of Daxx-mediated apoptosis by heat shock protein 27

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Disruption of the Raf-1-Hsp90 Molecular Complex Results in Destabilization of Raf-1 and Loss of Raf-1-Ras Association

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Cloning and functional analysis of BAG-1: a novel Bcl-2-binding protein with anti-cell death activity

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Bag1-Hsp70 mediates a physiological stress signalling pathway that regulates Raf-1/ERK and cell growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27

21 January 2018

1 reference

https://api.crossref.org/works/10.1126%2FSTKE.2001.93.RE1

21 January 2018

Identifiers

DOI

10.1126/STKE.2001.93.RE1

1 reference

2 August 2017

1 reference